Cannabinoids and aether/nerve flow; heart failure and TRP channels; exercise and nutrients that may increase aether flow and awareness of our body.
*also THC and derivatives found to inhibit an enzyme with a role in cancer promotion - and anandamide does not. This could explain some of the medical benefits of marijuana.
This post is about aether within our bodies and at our fingertips - and about TRP channel differences in heart failure. Hyperinflammation leads to endocannabinoid breakdown which can lead to overexpression of more inflammatory TRP channels. Reducing the hyperinflammation is the need rather than “inhibiting an overactive endocannabinoid system” as one research article phrased it. The problem is excess release of endocannabinoids due to excess intracellular calcium signaling. Lack of magnesium would be causal and excess dietary glutamate or aspartame or histamine excess, Retinoid Toxicity, or modern life and a stressful job - many variables - reducing as many as possible is a health need. With too many stressors, nutrient needs increase, deficiency is more likely to occur, and membrane breakdown releasing endocannabinoids occurs. Anyone that is severely ill is likely to also have developed cannabinoid deficiencies and leaky membranes.
News article about cannabinoids and autotaxin: THC, THCA and another derivative were found to inhibit autotaxin, an enzyme that may increase fibrosis and seems involved in glaucoma and cancer. Both are conditions that medical marijuana seems to help. See: ‘THC Inhibits Important Human Enzyme, Study Finds’ | News | Analytical Cannabis.
As a human knockout mouse for most endocannabinoids - I have first hand knowledge regarding the difference between being endocannabinoid deficient or replete - endocannabinoid sufficient. Some oil or edibles are needed to reach ‘replete’ because smoking alone is too much toxins. I can’t really get enough by smoking alone. When replete, I can feel energy flow throughout my body in a way that just isn’t present when I am deficient in cannabinoids. Discussed in the “ball of energy” and Feldenkrais Method section later in the post. With adequate cannabinoids from an external source (double BHMT gene allele) I can feel energy flow and sense my body significantly more than when I don’t have any medical marijuana. Pomegranate and chocolate and cardamom are a few foods that can help but it just isn’t enough to support health with my double dysfunctional gene. BHMT helps us form the phospho- end of the phospholipids that form endocannabinoids.
Endocannabinoid deficiency disrupts energy functions of the body.
Getting back to my initial point - cannabinoid adequacy seems essential to me to be able to have good aether flow/energy/gel phase/Exclusion Zone - healthy cytoplasm by another name.
‘Clinical Endocannabinoid Deficiency, (CED), and phospholipids’. (substack.com) This post has a list of conditions associated with endocannabinoid deficiency. Glaucoma is mentioned.
To add - cardiovascular health and endocannabinoids seems complex because the hyperinflammation causing endocannabinoid dysfunction is not mentioned in this abstract snippet:
“Alterations in components of ECS signaling have been associated with various conditions. For example, an underactive ECS is seen in post-traumatic stress disorder (PTSD) and migraine, whereas an overactive ECS is associated with metabolic disorders, obesity and CVD (Russo 2016b). Under normal conditions, modulation of the ECS has minor consequences on cardiovascular health; however, upregulation of endocannabinoid signaling and cannabinoid receptor expression has been observed in patients with coronary artery disease and atherosclerosis (Alfulaij et al. 2018; Fulmer and Thewke 2018). Accumulating evidence has shown that targeting the ECS may be beneficial for arterial hypertension, atherosclerosis, myocardial infraction and chronic heart failure (Alfulaij et al. 2018; Martin Gimenez et al. 2018).” (CC BY the authors: Azari, Kerrigan, O’Connor, 2020)
*The “overactive Endocannabinoid System (ECS)” or “upregulation of endocannabinoid signaling” in other words could be called increased inflammation that causes excess endocannabinoid release from membranes and downstream increases in TRP channel expression in endothelial tissue. Initially endocannabinoid have anti-inflammatory effects but too much free arachidonic acid, a metabolite - the lipid end of the phospholipid, activates TRP channels and leads to overexpression of TRP channels in membranes. This post gets into TRP channels that are overexpressed in the hearts of end-stage heart failure patients: ‘The Heart Revolution, con't - Mike Adams wins magnesium award’. (substack.com) Excerpt:
“Analysis of functional, clinical and biochemical data was used to confirm an end-stage heart failure diagnosis. Compared to myocardium samples from healthy donor hearts (n = 5), we detected a distinct increase in the expression of TRPC1, TRPC5, TRPM4 and TRPM7, and decreased expression of TRPC4 and TRPV2.” (Dragún, et al., 2019)
Arachidonic Acid (AA) metabolite activated:
Epoxyeicosatrienoic acid (AA-derivative) activates TRPC5 & TRPC6 - “Increases intracellular Ca+2 and also helps in translocation of channels to membrane in endothelial cell” ← increasing TRP channel expression and activity in endothelial - blood vessel wall tissue - increasing calcium entry into cells adds to hyperinflammation. TRP details: (Table 1, Kumar, Goswami, Goswami, 2013)
I was tired and didn’t get into the two that were found to be decreased in expression in the cardiac tissue of heart failure patients - TRPC4 (by 60%) and TRPV2. (Dragún, et al., 2019) TRPC1 and -5 were increased in expression. TRPC channels can also be activated by hypoxia so decreasing oxygen circulation would just add to the problems being caused by overexpression and activation of TRPC1 and TRPC5. Why the lack of TRPC4? I don’t know.
Excerpt from my pomegranate paper:
Bitter taste receptors, or possibly the niacin and butyrate GP109 receptor, may be co-regulators of TRPC4 and -5 channels. TRPC4 and TRPC5 channels also require PLC for activation. TRPC4 required coincident activation by a G coupled receptor and PLC. (Thakur, et al, 2016) Taste receptors are also G-coupled protein receptors. (Sanematsu, et al, 2014)
G protein coupled GP109 niacin receptor was heavily expressed on kidney podocytes Providing butyrate, also a ligand, protected wildtype mice from kidney injury induced by a single injection of Adriamycin, while those who had been treated with auto-antibodies against GP109 were not protected by the butyrate treatment. Providing a prebiotic diet that promoted butyrate production by the gut microbiome was also protective. (Felizardo, et al, 2019)
Zinc deficiency and lack of bitter tasting phytonutrients, low niacin and an unhealthy microbiome are all likely underlying factors in heart, kidney and liver failure. Leptin and IL-6 are affected by zinc deficiency and increased in inflammation.
Leptin activates the Sympathetic Autonomic Nervous System and can increase cardiovascular disease risks and it can also be affected by ANS activity. (Rahmouni, 2010) Leptin also has pro-inflammatory immune roles promoting Th1 cellular immunity and upregulates inflammatory cytokines TNF-α, IL-6, and IL-12, (Iikuni, et al, 2008), which may play a role in the increased mortality risk of COVID19 for obese patients. (Maurya, et al, 2021)
And woot there it is:
“Studies indicate potential roles for Rasd1 small G protein and leptin in TRPC4 cation channel activation. Galpha (i2) activates the TRPC4 channel by direct binding. This study identifies a novel role for TRPC4 in the regulation of autophagy in vascular endothelial cells.” (Numaga-Tomita, Nishida, 2020)
If leptin metabolism is disrupted and TRPC4 is reduced in heart failure, then autophagy in vascular endothelial cells would be reduced too. Dysfunctional cells would accumulate in the heart or blood vessel endothelial lining (similar to skin epithelial tissue).
TRPV2 has also been found to be overactive and add to fibrosis in other articles, inhibiting it is suggested as a treatment trial, however the basic function is protective and deficiency rapidly leads to cardiac dysfunction in lab mice studies. The channels are involved with conduction between nearby myocytes, cardiac muscle cells.
“The heart has a dynamic compensatory mechanism for haemodynamic stress. However, the molecular details of how mechanical forces are transduced in the heart are unclear. Here we show that the transient receptor potential, vanilloid family type 2 (TRPV2) cation channel is critical for the maintenance of cardiac structure and function. Within 4 days of eliminating TRPV2 from hearts of the adult mice, cardiac function declines severely, with disorganization of the intercalated discs that support mechanical coupling with neighbouring myocytes and myocardial conduction defects. After 9 days, cell shortening and Ca2+ handling by single myocytes are impaired in TRPV2-deficient hearts.” (Katanosaka, et al., 2014)
TRP channels are found throughout the body and inhibiting them has not been found to be an effective treatment due to ripple effects in other areas of function - too many adverse effects.
Reducing the hyperinflammation and nutrient deficiencies that lead to aberrant TRP expression and overactivity might help more. Reduce the sensitivity, restore function.
Rolling back the post history (looking for an aether topic) - a cerebellum exercise that may show early signs of increased mortality risk when it can’t be performed:
“And lest anyone, in addition to me forgot the initial point - the ability to stand on one leg longer than ten seconds is associated with a reduced mortality rate - but they don’t know why. In this post I present medical research that suggests the inability to balance on one leg longer than ten seconds is an indicator of underlying hyperinflammation and the resulting cerebellum dysfunction or damage.”
‘Standing on one leg - a life lengthening skill’. (substack.com)
*That post has a few other cerebellum exercises too. It is a lengthy, research intense post about Retinoid Toxicity and includes a long section on why cholesterol sulfate is a beneficial and needed nutrient. Vegans should eat some coconut products as a precursor to cholesterol as the vegan is cholesterol free. CoQ10, choline, niacin and St. John’s Wort would also likely be helpful and are discussed.
Research design to test the theory - exercise and nutrients to improve lifespan and quality of life: ‘Standing on one leg - research revised plan’. (substack.com)
The ‘ball of energy’ that you can form and feel between your hands.
I was looking for this post, on my PolyGen substack - warning label - this is a TMI post and not short: ‘Quantum health is connected to sexual health’. (substack.com)
Pertinent excerpts
Acupuncture and Reiki and Chakra work are all working with our energy fields. During health we have flow throughout the body with seven centers that have more powerful vortexes. Having a blocked chakra means that site is not registering any energy let alone a strong circular vortex of energy flow. Brendan D. Murphy discusses blockages in our root/sacral energy fields as being common in modern society. (1) I was blocked in two spots when I first read about chakras and checked (with the help of another person). The body’s energy vortex centers are strong enough to cause a dangling pendulum that has been hanging still to start moving, slowly at first but it can pick up pace and end up swinging in a circle. Blocked chakras don’t move the pendulum at all. I was less blocked when trying it again more recently.
Energy fields are being used for wound healing. We are energy beings, and our vibrations can be affected by music or loud traffic or EMF.
A Reiki healer has a very short video showing herself ‘building up’ a ball of energy between her hands and then sending it outward for distant healing. (3) I don’t know how well distant healing would work from a video recorded in the past, but the woman’s body language is loving and caring - and more to the point - DO try this at home. The ball of energy feeling is something anyone likely could feel if they slowed down enough to try and to pay attention to very subtle feelings.
I have always been able to feel a warm fuzzy feeling between my hands after rubbing my hands together a little to get the blood moving. It is more than body warmth though. As you move your hands into the ball shape and pull slightly apart, and return again closer together but not touching, repeat a few times, then you may be able to sense a magnetic like pulling sensation when your hands are about one to two inches apart. Holding the fingers in the ball like shape does seem to help - shown in the video. (2) Note - I have never been trained on forming or feeling the energy ball between my hands and just happened on the video by searching “reiki feeling the ball of energy in your hands vide” spelling error included. […]
I digress - our energy fields can be grounded by being close to the ground, barefoot ideally on clean sand or dirt or rock. Just stand there for 15-20 minutes and you may feel more refreshed afterwards. Maybe play with your ball of energy if you get bored. (2) Once the energy is flowing you can use if for self-healing or for others. If you have any achy spots, rest the palms of your hands on or just above the area in pain for self-Reiki. You may feel increased warmth and a slight flow like movement of energy.
Feeling the taffy -like, magnetic-like resistance as you gently pulse your hands together and apart slightly seems to gather aether energy within you and direct it too the fingertips. In Reiki the energized hands are held above or gently on a painful area on oneself or another person or pet and the gentle energy can seem soothing to the recipient.
“Bell Hands” and the Feldenkrais Method for releasing long held muscle tension.
Last night I signed up for an exercise course based on the Feldenkrais Method and the educator, Lavinia Plonka, shared “Bell Hands” - gently pulsing the fingers and thumb in and out without actually gripping or grasping with force. She described it as like a sea anemone opening and closing gently with the ocean currents. She then said Feldenkrais would direct people to point the energized hand towards an area of pain in your body. The sensation I felt, and technique is very similar to when gathering a ‘ball of energy’ between your two hands. Or Reiki practitioners might just rub their hands together a little to get the sense of increased energy flow.
‘Experience the Feldenkrais Method with Lavinia Plonka’ Course, theshiftnetwork.com.
My older sister was trained and extensively used Reiki for her diabetic cat’s pain and within a Reiki share group and I attended one training with her. During a heavy rainstorm at her brand-new home that had a leaky bay window - she got concerned about it leaking again and directed us both in Reiki energy to stop the gutters from overflowing so badly. I thought, huh?, but went along with her guidance. I have some natural ability but her practiced use was much stronger and I felt more of a pull of energy leaving me than when I do Reiki on my own. Between us both directing energy at the flooding gutter, I literally saw the overflowing water that was dripping straight down bend slightly toward the gutter outlet end, then let up, and then stopped overflowing. The gutter was flowing and emptying normally again, no dripping flood. During a directed distance healing for a person we know, her guidance, voice, whatever, felt really intense and eventually draining for me and I wanted to stop. She did soon after that. I may have said something. How much it helped the other person - I have no idea, sometimes the point is sending love - caring - concern.
Research on prayer has found it helped healing even when a patient didn’t know they were being prayed for.
Just because Western Medicine doesn’t understand something doesn't mean it is just fake news. Energy healing practices exist around the world and have for thousands of years. Western Medicine is like toddler aged in comparison.
Aether gathering by metallic/organic layers, would occur throughout the body and may collect more in areas like the heart or brain, throat or pelvis, where there is more bone and organ structure - forming containers for it.
The entire body is an aether collecting device, the eight layered heart would just be better at it, stronger, more potent by the layering. Our brain is also layered but of nerve and support cells and blood vessels - and contained in the skull - a collecting device of organic and metallic layers. The brain would also be a stronger aether collecting organ. All the chakras may be associated with skeletal and organ arrangements that increase aether collection. The pelvis and ribcage are also bony containers and the thorax is too (Root, Heart, and Throat chakras). People have discovered our energy nature in many cultures and called it different words. Jargon can help us or get in our way.
And - the layering of magnetic iron with organic material is in our hands, fingers, entire body. The eight layers of the heart muscle would just be a stronger aether collecting chamber. Our gently pulsing hands, whether together or the single Bell Hands, are collecting aether. The pulse in the thumb and fingers becomes more noticeable as you repeat the gentle pulsing motion. Whoosh, whoosh, whoosh, it is repeating the back-and-forth effect of the criss-crossing muscle fibers of the eight layered heart cone shape. The four layers with fibers angling toward the right would constrict in unison whooshing the blood one direction, like in an upright washing machine, and then the four layers with fibers angling toward the left would constrict in unison and whoosh the blood the other direction - creating a whirl pool within the heart chambers.
And - the gentle pulsing motion is key for helping relax and stretch out the body and increase the energy flow throughout the body. Consider the heart rate - the pulse - as the pulse you want to repeat. The exercises used in the Feldenkrais Method are gentle repetitive pulses of a tiny motion or holding the body at a full range of motion position for a while.
Focusing attention on a point in the body, or on a pain point and then going outward - getting more in tune with all parts and their connections is a basis to the Feldenkrais Method. Releasing long held tension is a goal - trauma recovery and reducing body armoring without using that same term. We can hold fear body language all the time, and it leads to restricted motion and pain - or stifled energy that may lead to other health or mood issues.
I also signed up for a Biodynamic Breathing course that also focuses on releasing held tension. Undulating the spine during sitting breathwork is the gist so far but it was just the introduction. Other areas of tension will be discussed in separate videos.
‘Release Trauma From the Body With BioDynamic Breathwork’ with Giten Tonkov, theshiftnetwork.com
Motion itself - sitting less - is a heart healthy habit and good for maintaining range of motion. When we don’t move as much, and age, or have excess calcium and too little vitamin K, bone spurs can develop and really restrict range of motion or cause pain when walking. I have experienced some of those problems. Three weeks of Netflix binge watching while feeling sick left me with very reduced shoulder motion on the side I laid on on the couch. Later once feeling better and active again, I slipped while hiking off a slippery log. Both arms flew up backward abruptly, so far up and back that the restraining bone spur must have snapped off. It was excruciating pain for a few minutes and I probably sat down, and the pain eased and then I could move my arm again fully. The rotator cuff must have had a bone spur limiting how far it could rotate.
Using our full range of motion helps us stay more flexible and with less pain. Exercises that focus on posture and alignment of the body, like the Feldenkrais or Pete Egoscue methods, help keep our inner bodysuit from getting tight or twisted in some areas. Our fascia, inner membrane that separates the skin from the organ areas of the body is like a full body suit and not moving enough can lead to it feeling tight or constricted. Gentle stretching to the peak range of motion for individual comfort and focus on alignment can help keep the proverbial wrinkles out of your internal bodysuit.
The Heart Revolution series:
‘The heart is a vortex not a pump - Frank Chester video link / many links The Heart Revolution event, plus a Substack by Katherine Boyle and a related movie (includes some spoilers - Violet).’ Jan 17, 2023, (substack.com)
‘The Heart is an aether gathering chamber (my thought); and More from The Heart Revolution videos.’ Jan 18, 2023, (substack.com)
‘Better zinc levels associated with fewer migraines. More bitter taste sensitivity linked to less CoV - and what are bitter taste receptors doing in the heart?’ Jan 18, 2023, (substack.com)
‘The Heart Revolution, con't - Mike Adams wins magnesium award.’ Jan 18, 2023, (substack.com)
‘Cannabinoids and aether/nerve flow; heart failure and TRP channels; exercise and nutrients that may increase aether flow and awareness of our body.’ Jan 19, 2023, (substack.com)
‘New beginnings for heart health education.’ (substack.com) (Jan 30, 2023)
Disclaimer: This information is being shared for educational purposes within the guidelines of Fair Use and is not intended to provide individual health care guidance. Please seek a functional health practitioner for individual health guidance.
Reference List
(Azari, Kerrigan, O’Connor, 2020) Azari, E.K., Kerrigan, A., O’Connor, A., (2020) Naturally Occurring Cannabinoids and their Role in Modulation of Cardiovascular Health, Journal of Dietary Supplements, 17:5, 625-650, DOI: 10.1080/19390211.2020.1790708 https://www.tandfonline.com/doi/full/10.1080/19390211.2020.1790708
(Katanosaka, et al., 2014) Katanosaka, Y., Iwasaki, K., Ujihara, Y. et al. TRPV2 is critical for the maintenance of cardiac structure and function in mice. Nat Commun 5, 3932 (2014). https://doi.org/10.1038/ncomms4932 https://www.nature.com/articles/ncomms4932
(Numaga-Tomita, Nishida, 2020) Numaga-Tomita T, Nishida M. TRPC Channels in Cardiac Plasticity. Cells. 2020 Feb 17;9(2):454. doi: 10.3390/cells9020454. PMID: 32079284; PMCID: PMC7072762. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072762/