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Standing on one leg - research revised plan.
Needs more research - a plan for that.
Dementia is preventable - often - but the damage can start twenty years prior to obvious symptoms of forgetfulness. Early onset Alzheimer’s dementia is now being diagnosed starting at age 45 - so a 25-year-old’s actions may be setting the stage for the later diagnosis. Excessive carbohydrates, lack of produce, lack of trace nutrients, lack of cholesterol possibly, excess omega 6 fatty acids, excess trans fats, AGEs, and other food additives or chemicals that are produced during manufacturing of ultra-processed foods.
Hyperinflammation leads to chronic neurodegeneration and other damage in the body and organs. Identifying the inflammatory things in modern life and one’s personal life is step one, substituting healthier habits or foods is step two. Take away the flamestarters, and add more fire extinguishers.
A TEDx talk gives a nice overview of the problem - Alzheimer’s is happening more frequently and at younger ages; and the solution - it is often preventable with lifestyle changes. Many of the important strategies for reducing risk are briefly described as the speaker discusses his personal story - his mother was diagnosed with dementia in her early 50’s. He has since been changing his own diet and working on protecting his own brain.
“You are never too young, or too old, to make a brain healthy choice.” - Max Lugavere.
Dementia is preventable through lifestyle. Start now. | Max Lugavere | TEDxVeniceBeach (Youtube).
Excess Retinoic Acid or histamine, or glutamate and aspartate in foods, or glyphosate and organophosphates, or an excess of omega 6 fatty acids in ratio to omega 3 fatty acids, or lack of methyl B vitamins and choline, or lack of cholesterol sulfate, and lack of Nrf2 promoting phytonutrients….EMF, poor sleep, and other things….all may be adding to hippocampus and other brain degeneration or misfolded protein accumulation.
Starting anywhere can help. Gradually changing habits, and then changing some more habits can help make it more doable, and less overwhelming. Having a functional health oriented guide may help too, whether a doctor, health coach or a book. This is not easy = true.
It gets easier as more changes are working, it can be easier to tell when something was inflammatory. Instead of waking up every day with grogginess and pain, only an occasional morning may be like that and it would be then easier to notice - Oh, yesterday I went out for lunch with friends and had something unusual. Detective work - what specifically was unusual? Add that to the list of Maybe that is a problem food - pay more attention if eating it again. Or if the reaction was too negative, and that was the only new thing, add it to the Skip that in the future list.
My research revision plan:
Retinoic Acid Excess Study / Standing on One Leg Study / FAS/ADHD
Cohorts could include a control group that does not have any overt diagnoses or symptoms; experimental subjects might include people with ME/CFS, fibromyalgia, and FAS, ADHD, and alcoholism, and possibly branch out to include autism spectrum disorder, Alzheimer’s dementia, and cerebellar ataxia. Also of interest: people with LongCovid, CoV injection injured, and traditional vaccine injured cohorts.
Subjects would be compared to themselves for improvement/no change/worsening between an initial screening and later screenings after treatment changes were initiated. The control group screening results would be used as a baseline suggesting “normal health”. An initial stage would include smaller groups who receive more in depth health screenings. The information learned might then help narrow focus more for a large group study.
Labs of interest for a “Before Treatment” screening:
Retinoic Acid, cholesterol sulfate, methyl folate, methyl B12, B6, zinc, copper, vitamin D - 25-D and 1, 25-D, CoQ10, Complete Blood Count (CBC), insulin, blood glucose, Hbg A1c, blood lipid panel, Omega 3/6 ratio, ferritin, RBC magnesium, iodine, manganese, boron, glutathione, and melatonin.
Inflammatory biomarkers - homocysteine, TNFa, NF-kB, Il-6, Il-17, Il-1a, histamine.
Environmental or food toxins - bromide, fluoride, glyphosate, organophosphates.
Methylation, Vitamin D Receptor, ROR alleles, BHMT, APO, other metabolic gene alleles known to be more common in autism, FAS, ADHD, or Alzheimer’s dementia.
Other comorbid conditions, medication use / family history.
Migraine or chronic pain symptoms.
Eczema, peeling skin, rashes, dandruff, alopecia, GI symptoms or SIBO, allergies/food sensitivities, any other symptoms suggesting Leaky Bowel Syndrome.
Symptoms of Retinoid Toxicity such as cheilitis/chapped lips or kidney or liver disease.
Symptoms of Histamine Excess.
Mental health history, any suicidal thoughts or attempts? Psych meds?
Prenatal and lactation or menstrual history, including peri/menopause.
Man-opause (not a real word) or other age related symptoms?
Questionnaires or Logs:
Food Frequency Questionnaire - what is typically eaten once over a week or month, or daily? Check boxes next to a list of foods.
3-7 day Food and Symptom Log - actually write down everything for a few days, because nobody really remembers specific details that well after a couple days.
Sleep Habits - Evaluate with a questionnaire to check if circadian cycle would be negatively affected or helped, and/or Log for 3-7 days to see if sleep is a problem.
Exercise/activity level - physical or chemical stress test possibly, the standing on one leg test, and a questionnaire or log or step counter to assess exercise habits or daily activity level.
The Before screening is also for diagnostic purposes - identify what specific strategies each individual needs and mitigate individually as appropriate. The Experimental Treatment would have a basic plan that would be individualized as part of the approach - the premise being that an individualized approach is what is needed for stopping hyperinflammation from continuing into misfolded protein accumulation and fibrotic damage. Either in the brain or elsewhere in the body, fibrotic damage leads to cell death and dysfunction in the area. Pain and inflammation may also occur.
The Restore Function approach - fix everything we identify in the pre-screening, and use a base diet that everyone gets roughly equivalent.
The control group will get a base diet and will serve to show safety and serve as a side effect control group. Benefits, no change, or worsening will be observed and their before and after screening will be compared to themselves and an average change with the experimental cohorts.
Experimental participants will be grouped into cohorts by their primary diagnosis. An initial question of interest is the link between FAS, ADHD, and retinoic acid overactivation prenatally in the cerebellum, and whether it is continuing throughout life.
The question is also of interest in other conditions -
Is retinoic acid overactivation occurring after infection or immune challenge and does that continue afterwards for life? -
Traditional vaccine injury and CoV injection injury, and LongCovid may involve retinoic acid overactivation and/or histamine excess. Autism, Alzheimer’s dementia. Parkinson’s disease, Multiple sclerosis, and other neurodegenerative conditions may also have similar underlying issues. Akathisia and Extrapyramidal symptoms, drug side effects of suicidality, may also be related to imbalance resulting from retinoic acid and histamine excess.
The foods involved are common and just happening to rule them all out long enough to see improvement would not be likely. Identifying and avoiding some would be likely and interesting to see if the cohorts have patterns in food sensitivity.
The kidneys, liver and brain are at stake with retinoic acid excess. Chronic histamine excess is more damaging to the brain than other organs and can cause severe mood or behavior changes including mania or debilitating anxiety and paranoia - not rational but generally misdiagnosed as a mental health disorder rather than food sensitivity. Heart irregularity, high blood pressure, and dizziness may also be symptoms of histamine excess along with seasonal allergy type congestion or asthma.
Mitigate for any metabolic gene alleles that were identified such as methyl B vitamins for methylation issues or DMG, methionine and cannabinoids for a BHMT allele. Liposomal vitamin D preparations may benefit people with VDR alleles. *This would include the control group - do they have any differences that don’t seem to be affecting their health? yet?
Educate on circadian cycle and good sleep/light habits. Log for compliance/non.
Educate on cerebellum exercise and log for compliance/non.
Provide Epsom salt soaks or topical creams for magnesium and sulfate; log foot soaks or baths or topical product use. Magnesium chloride might be preferred by some people but would not provide sulfate. Sulfur containing vegetables would be needed.
The Basic Diet - Moderate carb ~ 30/20/50
The base diet will include ~ 30% calories from carbohydrates which include resistant starches in raw and cooked forms; ~ 20-25% calories from protein; ~ 45-50% calories from fats, including healthier saturated fats from coconut or cocoa butter (dark chocolate is also rich in phytonutrients but is a source of oxalates which may be inflammatory in excess or for some people). Low glycemic index meals and snacks will be planned. The base diet will be low in glyphosate and pesticide food selections and low in ultra-processed foods. Use of trans fats and Omega 6 rich vegetable oils will be limited in use, olive oil, sesame or coconut oil will be used.
Provide the base diet and/or supplements and fortified drinks or foods that include:
EPA/DHA, and provides a reduced Omega 6 to 3 ratio;
Nrf2 promoting phytonutrients in foods or supplements;
Magnesium glycinate or threonate, if topical Epsom salt soaks or magnesium chloride is not preferred; D3 supplements, possibly liposomal; mixed trace mineral supplement with iodine if not hyperthyroid; extra zinc based on age of the participant, older people need more than the guidelines recommend.
Mitochondrial support: CoQ10, glycine, methionine, cysteine, methyl B complex, and high dose niacin and melatonin for participants who are willing to try it. Lysine and taurine may also be helpful in an amino acid supplement drink.
Low histamine diet for those identified or suspected of having excess or MCAS.
Low/very limited to no vitamin A and carotenoid foods for those identified or suspected of having excess activation of Retinoic Acid.
Individualize the diet for, and log, other food sensitivities; whether lectins, TRP channel activators, oxalates, or food allergies, or molecular mimicry autoimmune food sensitivities (gluten is like the thyroid tissue and can be a problem in autoimmune thyroid conditions for example).
DHEA supplements may be helpful for all participants over age 35 and progesterone cream for women with symptoms of perimenopause or who are menopausal.
This is in depth - small cohorts that are followed closely for a complete picture - and overall goal, improve function and quality of life - see if the blood work also improves and cognitive health parameters. The long term goal would be to prevent chronic degeneration in the brain and body.
Dementia is not a standard part of aging - needing extra zinc is and also paying more attention to getting about 3 ounces of protein equivalents at each meal is a standard part of aging, as we don’t store amino acids as well or rebuild muscle as well. Being active is also important so the bones and nerves are continuing to send “We are needed, sustain us!” messages which help keep calcium in the bones and nutrients flowing to the nerves from our support astrocytes and other glial cells.
Modern life has issues, CoV just added to the problems we already had.
Spartacus on what kind of mind control/gene altering biotech/nanotech may we realistically expect?: a review of tech and biotech research and medical trends. It looks grim for free will and nonGMO humans. The research exists for gene editing that could affect us whether we want or not. Being well nourished might help detox foreign particles before they are uploaded to a cell nucleus.
Odd times, peace be with you.
Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.