Spike list condensed with food additives, [:-)
Does anyone else title their work last?
List of ways chimeric spike messes with physiology (and pomegranate peel helps against most of the list, and other phytonutrients and functional foods also help):
The chimeric spike has many ways to disrupt function and add to hyperinflammation ~ cytokine storm ~ sepsis:
SEB toxin - similar effects, PAMPS immune response possibly.
Fusion cleavage site (FCS) gp120 HIV-1 like sequence can cause infection of cells and free the S1 subunit to effect other receptors like the Dectin-1 receptor and others. See: (1) (PDF) The Myth of the Blind Watchmaker (Rixey, 2022, researchgate.net) Pomegranate peel is a HIV-1 gp120 inhibitor.
Lipopolysaccharide (LPS) bacterial endotoxin has increased risks when spike is present. Gut dysbiosis could add to more LPS being produced. Resistant starch and plentiful zinc and pomegranate supports a healthy gut microbiome.
Staphylococcus Enterotoxin B (SEB) sequence or effects is near the FCS and gp120 inserts in the chimeric spike RNA sequence. Edits- 1 and 4 are the same.
Dectin-1 receptor blocking leading to fungal infection risk. Beta-glucan is protective; found in mushrooms, Nutritional Yeast Flakes and oatmeal and barley, however lower carb diets are also protective against fungal infections. Glyphosate increases risk of fungal infections, and they can be a low-level lung problem that isn’t identified early enough. Pomegranate peel is a broad spectrum anti-microbial and helpful against fungal infections and Candida albicans.
ACE2 and TMPRSS2 receptors, and various parts of the SARS-CoV-2 viral proteins are included in this section.
“Angiotensin converting enzyme 2 (ACE2) and trans-membrane protease serine 2 (TMPRSS2) are the two major host factors that contribute to the virulence of SARS-CoV-2 and pathogenesis of coronavirus disease-19 (COVID-19).” (Senapati, et al., 2021 ACE2 and TMPRSS2 receptor blocking leads to edema like lung symptoms. Pomegranate peel and many herbals are protective.
Pomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs, (Tito, et al., 2021).
“There are at least 300 plants that have ACE inhibitors activity, including some well-known medicinal and food species, such as cinnamon (Cinnamomum zeylanicum Blume or Cinnamomum verum J. Presl.), pepper (Capsicum spp.), olive (Olea europaea L.) [olive leaf extract, also olive oil and olives), hawthorn (Crataegus pinnatifida Bunge) [helpful for histamine excess and neuroinflammation], black nightshade (Solanum nigrum L.), passion fruit (Passiflora edulis Sims) and grape (Vitis vinifera L).47,50,51 ACE inhibitors from natural products belong to several phytochemical classes, including flavonoids, xanthones, alkaloids, peptides, terpenes, and tannins.” https://pubs.rsc.org/en/content/articlehtml/2020/ra/d0ra03774e#cit47
3CLpro inhibitors (the main protein of SARS-CoV2): Essential oils include bioactive chemicals that inhibit (protect from spike)
“mono and sesquiterpenes geraniol, linalool, (E)-β-farnesene and (E)-nerolidol presented in silico inhibition of 3CLpro….67 These compounds can be found in several plants species with ancient and very well-known uses as foods, medicinal and aromatics, such as lemon balm (Melissa officinalis), lemongrass (Cymbopogon citratus), lavender (Lavandula angustifolia), geranium (Pelargonium graveolens), basil (Ocimum basilicum), mandarin (Citrus reshni), cinnamon (Cinnamomum zeylanicum), chamomile (Matricaria recutita), ginger (Zingiber officinale) and copaiba (Copaifera sp.).67” Natural products' role against COVID-19, (da Silva Antonio, A., et al, 2020) « many possibilities https://pubs.rsc.org/en/content/articlehtml/2020/ra/d0ra03774e#cit47
It mentions in one or more sections for protecting body receptors or inhibiting SARS-CoV2 proteins: quercetin, kaempferol, ginger, chloroquine, many citrus and pomegranate peel or green tea polyphenols, genistein (source: traditionally fermented soy foods, nonGMO, is my recommendation for use of soy in the diet), cinnamon, pepper, lactose (milk sugar), Silybin (Milk Thistle), Baicalin, Apigenin, Glycyrrhizic acid (licorice root, non DGL - full strength), Nicotianamine (iron chelator found in all plants. Asparagus is mentioned as a source - it may be more bioavailable in grasses (sciencedirect), Scutellarin. Several are shown in chemical form along with six citrus bioflavonoids - seriously citrus peel helps immensely - the six in the graphic: hesperidin, hesperitin, neohesperidin, nobiletin, naringin, and naringenin. Also “turmeric (Curcuma longa L.) and wormwood (Artemisia absinthium L.)51” (https://pubs.rsc.org/image/article/2020/RA/d0ra03774e/d0ra03774e-f3_hi-res.gif) See page Citrus peel on jenniferdepew.com for food ideas and quantity to use of citrus peel (about 1/2-1 teaspoon of the zest layer or more of the milder inner pith per serving. If symptoms are severe repeat every six hours.) See page Phytonutrients on jenniferdepew.com for food sources for some of the others mentioned.
Baicalin (Skullcap) / scutellarin, 250 mg
Antiviral, anti-HIV-1, anti-cancer
Dandelion leaf extracts
Galectin-3 increase - pectin and milk sugar might be protective. The inner pith of pomegranate peel has pectin and jam or apples or rhubarb or citrus peel pectin.
VEGF, galactin-3, chimeric spike, and milk sugar. (substack.com)
TRP channels with ankyrin repeat domains may become dysfunctional - tinnitus, hearing loss or vertigo may result. Antivirals and pomegranate peel to block the fusion cleavage site from separating would be protective. Adequate magnesium and hydration are needed, methyl B12 and saffron or gingko biloba may help inner ear Hair cells, which are fragile and only shaped like tiny hairs or a layer of fur that can wave with head motion or sound waves in the fluid surrounding them. Loud sounds, and one-sided loud sounds (cell phone/instruments) can increase risk of damage that affects hearing or sense of balance/vertigo. The Hair cells don’t repair well - which means protect them in the first place. Spike seems like a direct ototoxicity.
p53 down regulators may be protective. (Wu, et al., 2021) p53 has a regulatory role over cell apoptosis or cell cycle arrest if there is DNA damage and in ~ 50% of cancer types there is excess expression, so inhibition is desired. (Ozaki, Nakagawara, 2011) Promotion might be the goal if senescent cells are a problem. (Mijit, et al., 2020) Promoting SIRT-1 decreases p53 activity and inhibiting it increases p53 activity. MicroRNA-34 has a regulatory role and is increased by increased p53 activity which would help stabilize levels. (Misso, et al., 2014) Pomegranate peel promotes SIRT-1 activity. (Caruso, et al., 2020)
Cancer and hyperinflammation risks: NFkB is greatly promoted in many ways and Nrf2 inhibited - which reduces glutathione production and DNA damage repair which can lead to cancerous changes in DNA. See graphics with foods and phytonutrients that promote Nrf2 towards the end of this post: Nrf2 & NF-kB - 2 proteins to know. (substack.com)
Prion like misfolding sequences in the spike fragments may increase fibrotic clotting. Nattokinase and serrapeptase seem to help. Take opposite of food for blood clearing benefits, with meals as a digestive enzyme aid. I take one capsule sometime in the middle of the night when I wake up.
Polyphenols and magnesium and other trace minerals help stabilize proteins in their proper folds. Delphinidin is an example found in black beans and black/purple varieties of produce or rice, and blue flowers like chicory, Blue Lotus and Blue Butterfly Pea flowers used in teas or supplements. It is also found in the brilliant blue delphiniums for which delphinidin is named, but those flowers include toxins - do not eat or use for tea. Not having Endoplasmic reticulum overload is also important. See post: Endoplasmic Reticulum stress, misfolded proteins, allosteric modulators and delphinidin. (substack.com)
A phytonutrient in bay leaves and delphinidin were found to have potent anti-SARS activity. See: Bay leaves - anti SARS-CoV-2 - and good in soup. (substack.com) Gumbo file is also mentioned - it has medicinal use historically for “for urinary tract disorders, swelling in the nose and throat, syphilis, bronchitis, high blood pressure in older people, gout, arthritis, skin problems, and cancer. It is also used as a tonic and “blood purifier.”” It has also been used topically for skin problems and achy arthritic joints. https://www.rxlist.com/sassafras/supplements.htm
Autoimmune antibodies against the receptor types that spike can block may occur. Phospholipid autoimmune conditions have also been observed as new onset after CoV infection in LongCovid patients.
See: Cannabinoids & blood vessels - and LongCovid. - about “LongCovid fingers” (substack.com)
Increasing allergic like sensitization seems to occur with repeated exposures to boosters or passive exposure (busy crowds, public facing job). Avoiding the toxin 100% is the ideal for autoimmune or allergy problems. Adequate vitamin D in advance is protective against the problem occurring but is too little too late after the antibodies have been formed.
Adequate protein and magnesium are needed for vitamin D metabolism and storage. Adequate protein and phospholipids are needed for magnesium storage in the inactive form. Protein carriers are needed so that we can have a backstock of each, otherwise the conversion to active vitamin D is rapid and body can get excess if the enzyme to breakdown the active D is not available. Adequate protein also helps with glutathione production for antioxidant support of mitochondria.
See: NLRP3 Inflammasomes & Spike Protein - includes myokines & many other sections (substack.com)
Gut dysbiosis is an issue as it can be caused by stress and inflammation and then increases risks of allergies and autoimmune reactions to food proteins. It may also represent an ongoing reinfection risk as SARS-CoV2 can be a bacteriophage and infect bacteria. Increased leptin levels and leptin resistance may also be a factor increasing hyperinflammation that is related to microbiome dysbiosis. Low zinc is causal in gut dysbiosis, leptin issues, and elevated IL-6 in older adults. Gut dysbiosis leads to low butyrate and short-chain fatty acids which leaves the colon more at risk for cancer and inflammation.
See: Leptin Resistance Protocol; obesity, gut dysbiosis, hyperinflammation. Supplement examples included, link to Fullscript for more info about them. (substack.com)
See pages Resistant Starch/Butyrate and How Much Butyrate? on jenniferdepew.com. Answer, about 500 mg butyrate per day as a supplement but having a healthy gut microbiome that makes it from adequate starches in the diet would be far better. Also see page Zinc and Microbiome.
nAChR blocking by the CoV jab versions of the chimeric spike - seems to be occurring. nAChR blocking was not observed in a research study with the infection version of the chimeric spike - however this is meaningless/non-proof to me as the jab version of the chimeric spike was significantly modified. Testing the original version tells us little to nothing about what the modified jab version might be doing. The excessive menstrual bleeding after passive exposure was not seen with CoV infections in 2020, it was seen after CoV jabs. It started after the DoD bioweapon prototype jabs were introduced in late 2020 or early 2021 - and increased. Infants, young girls, post-menopausal women - it wasn’t just a problem being experienced by menstruating women.
See: Snake venom toxin in the spike protein? (substack.com)
I don't like the Count the Miscarriage/dead babies game. Let's do something helpful instead. (substack.com)
Catecholamine-mediated stress myocarditis, spike S1 and alpha 7 nAChRs. Can we please talk about solutions yet? Nicotine lozenges are one, and I linked to more in an older post. (substack.com)
Cholinergic inhibition and breathing. (substack.com) Paralytics can also paralyze breathing in another astonishing CoV era coincidence.
Nature has a vast medicine cabinet that smells and tastes delightful and pungent - the dose is the potency. Some black pepper is medicinal - too much is an irritant and will lead to running nose and saliva to try to wash it away - a natural defense action of TRP channels which black pepper activates. The advantage of functional foods is the tongue’s ability to help dictate the dose - bitter phytonutrients taste good up to a point and then start tasting too strong. Bitter nutrients help with satiety and weight and blood sugar control.
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The Basic Stack and Extended stack herbal guidance for prenatal and child-bearing age women and for children - Prenatal/Child page on jenniferdepew.com. Page Nutrients and page Cofactors includes a summary and dosing ranges for ~ adult males which is similar for prenatal/lactating women and a little higher than for adult females. Older adults need extra zinc than current guidelines, about 50 mg/day after age 65.
I am tired and posting this to get a shareable draft.
To add: berberine, black cumin seeds and honey, or black seed oil, topical use too, for shingles.
Oral health and microbiome seems a risk factor which black seed oil by mouth, swish a little can help, or pomegranate products. Pomegranate juice alone is a strong enough oral rinse antimicrobial to leave the mouth with less dental risk pathogens - just drink some of the juice daily. No tooth brushing was used in the study, just a few ounces of juice.
More on the oral health link:
Time to brush my teeth, swish some black seed oil and go to bed.
To add: TLR4 and VAIDS and cancer risk.
Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
Thanks for reading deNutrients - News to Use! Subscribe for free to receive new posts and support my work.