Catecholamine-mediated stress myocarditis, spike S1 and alpha 7 nAChRs.
Can we please talk about solutions yet? Nicotine lozenges are one, and I linked to more in an older post.
Problem presented in a recent post by Dr. Alexander: myocarditis following second CoV injection in two teen boys, and the cases were different from typical myocarditis. Instead, the cases resembled catecholamine-mediated stress (toxic) cardiomyopathy.
Gill et al.: "Autopsy Histopathologic Cardiac Findings in 2 Adolescents Following Second COVID-19 Vaccine Dose"; Myocarditis particularly in teenage boys has been reported following 2nd Pfizer dose
The myocardial injury seen in these post COVID vaccine hearts is different from typical myocarditis & has an appearance most closely resembling a catecholamine-mediated stress (toxic) cardiomyopathy. Dr. Paul Alexander (SubStack)
Possible mechanism of action: There are alpha 7 nicotinic acetylcholine receptors (α7nAChR) in the adrenal glands that are important during development and into adulthood for function and development of the gland.
"The transient expression of α7 during adrenal gland development and its prominent co-expression by a subset of NE chromaffin cells in the adult suggests that the α7 receptor contributes to multiple aspects of adrenal gland development and function that persist into adulthood." (Gahring, et al, 2014)
Chimeric spike S1 subunit blocks nAChRs. (Korzeniowska, et al, 2021) Disrupting a regulatory control of the adrenal gland function may be leading to increased catecholamine production, myocarditis, and various other effects like infertility and miscarriages. Are there snake venom/conotoxin like effects in the chimeric spike or injections? Toxin-like peptides were found in urine samples of a small cohort of peope who had recovered from Covid19 compared to controls. (Brogna, et al., 2021)
Thin males who receive mRNA Lipid nanoparticle injections are more at risk for myocarditis probably due to less body fat content, what little they have is cushioning around the heart. The LNPs are attracted to fat tissue and fatty acid rich cell membranes. *Underground Court Lady’s theory - circa Twitter ~ 2021. So the spike production is concentrated around their heart tissue instead of spread throughout the body like it might be in a female or more plump person.
The α7nAChRs have a protective effect in murine viral myocarditis. Use of an agonist helped while an antagonist had negative effects. (Li-Sha, et al, 2017)
"Recently, we have also demonstrated that cholinergic stimulation with α7nAChR agonist nicotine had a protective effects in murine viral myocarditis, and selective α7nAchR antagonist methyllycaconitine had a deleterious effects in the same setting (Zheng et al., 2014; Ge et al., 2015, 2016)." (Li-Sha, et al, 2017)
Why not nicotine lozenges or gum?
(*The patches cause skin irritation and may have polyethylene glycol.)
Nicotine lozenges would likely be protective for chimeric spike issues. When faced with a cholinergic paralytic, grab an agonist. (Korzeniowska, et al, 2021) Yes, things are bad, can we ever talk about solutions?
Yes, nicotine is addictive and moderation may be difficult for some people, but death by myocarditis is probably not great either.
Factoid: Tobacco is a revered spiritual plant for indigenous Americans.
The cholinergic blocking risks would affect people who have passive exposure symptoms in addition to the people who received a CoV injection or more than one.
Repeated exposure to the chimeric spike seems to increase the allergic like over-response by the body - flu-like body aches after passive exposure for me, but faster and worse of a reaction. Congestion, swollen lymph nodes, tired, night sweats - I drink Wormwood/pomegranate peel tea and take extra black seed oil and feel better in a day or two instead of getting worse. I use nicotine lozenges daily since I started - and yes it would cause withdrawal to stop. It helped my ADHD when I started and I haven’t tried to stop to see if any symptoms worsened.
Other possibilities besides nicotine as agonists for nAChRs:
Also mentioned in a recent post SPED fans - a Dec. 2020 Public Comment to the FDA. They were warned. (substack.com) - and worth a repeat:
This post has a section with possible therapeutics to use against the S1 subunit, in the second part, galantamine in addition to Nrf2 promoters, and “Tangent: “Cytisine and cytisine derivatives” may also be effective as a non-nicotine nAChR receptor agonist. (4)” I include a list of them with nutrients, a nucleotide, magnesium threonate, others:
When some people keep telling you they don’t know what is causing a problem, why expect them to be able to help solve it?
Truly it is odd that nAChRs are not being discussed more.
Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
Reference List
(Brogna, et al., 2021) Brogna C, Cristoni S, Petrillo M, Querci M, Piazza O, Van den Eede G. Toxin-like peptides in plasma, urine and faecal samples from COVID-19 patients. F1000Res. 2021 Oct 14;10:550. doi: 10.12688/f1000research.54306.2. PMCID: PMC8772524. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772524/
(Gahring, et al, 2014) Gahring LC, Myers E, Palumbos S, Rogers SW, Nicotinic Receptor Alpha7 Expression during Mouse Adrenal Gland Development, PLOS One, August 5, 2014, https://doi.org/10.1371/journal.pone.0103861, https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103861
(Korzeniowska, et al, 2021) Korzeniowska A, Ręka G, Bilska M, Piecewicz-Szczęsna H, The smoker's paradox during the COVID-19 pandemic? The influence of smoking and vaping on the incidence and course of SARS-CoV-2 virus infection as well as possibility of using nicotine in the treatment of COVID-19 - Review of the literature. Przegl Epidemiol. 2021; 75(1):27-44. https://pubmed.ncbi.nlm.nih.gov/34328284/
(Li-Sha, et al, 2017) Li-Sha G, Xing-Xing C, Lian-Pin W, De-Pu Z, Xiao-Wei L, Jia-Feng L, Yue-Chun L. Right Cervical Vagotomy Aggravates Viral Myocarditis in Mice Via the Cholinergic Anti-inflammatory Pathway. Front Pharmacol. 2017 Jan 31;8:25. doi: 10.3389/fphar.2017.00025. PMID: 28197102; PMCID: PMC5281590. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5281590/
I find this incredibly interesting. I happened upon a nice couple in a grocery store parking lot during the height of the mask wearing - they did not have masks on as I did not either. They were both smoking cigarettes. I asked them if they had gotten SARS Cov II or the jabs. They said neither - they thought their smoking had actually helped them. I complimented them on not wearing the masks.
I was hoping I would at some point read something like this!
Can we please talk about nicotine is what I've been harping on since 2020. Thank you for this post!