SPED fans - a Dec. 2020 Public Comment to the FDA. They were warned.
SPED fans - a Dec. 2020 Public Comment to the FDA. They were warned.
PUBLIC SUBMISSION: Comment from J. Patrick Whelan MD PhD, Posted by the Food and Drug Administration on Dec 9, 2020
I am a pediatric specialist caring for children with the multisystem inflammatory syndrome (MIS-C). I am concerned about the possibility that the new vaccines aimed at creating immunity against the SARS-CoV-2 spike protein (including the mRNA vaccines of Moderna and Pfizer) have the potential to cause microvascular injury to the brain, heart, liver, and kidneys in a way that does not currently appear to be assessed in safety trials of these potential drugs.
Puntmann et al. (JAMA Cardiol. 2020;5:1265-1273) showed that the prospective study of 100 German patients who were recently recovered from COVID-19 revealed significant cardiac involvement on cardiac MRI scans in 78% of them, an average 2-1/2 months after their recovery from the acute illness. Two-thirds of these patients were never hospitalized, and there was ongoing myocardial inflammation in 60%. The abnormalities occurred independent of preexisting conditions, severity of the initial disease, and overall course of the acute illness.
Magro et al. showed that there is complement-mediated damage even in grossly normal skin of coronavirus-infected individuals (Human Pathology 2020:106:106-116). They have also shown (Magro et al. Annals of Diagnostic Pathology 2021:50 in press ) that ACE-2 receptor expression is highest in the microvasculature of the brain and subcutaneous fat, and to a lesser degree in the liver, kidney, and heart. They have further demonstrated that the coronavirus replicates almost exclusively in the septal capillary endothelial cells of the lungs and the nasopharynx, and that viral lysis and immune destruction of those cells releases viral capsid proteins (or pseudovirions) that travel through the circulation and bind to ACE2 receptors in these other parts of the body leading to mannan-binding lectin complement pathway activation that not only damages the microvascular endothelium but also induces the production of many pro-inflammatory cytokines. Meinhardt et al. (Nature Neuroscience 2020, in press) show that the spike protein in brain endothelial cells is associated with formation of microthrombi (clots), and like Magro et al. do not find viral RNA in brain endothelium. In other words, viral proteins appear to cause tissue damage without actively replicating virus.
Is it possible the spike protein itself causes the tissue damage associated with Covid-19? Nuovo et al (in press) have shown that in 13/13 brains from patients with fatal COVID-19, pseudovirions (spike, envelope, and membrane proteins) without viral RNA are present in the endothelia of cerebral microvessels. Furthermore, tail vein injection of the full length S1 spike subunit in mice led to neurologic signs (increased thirst, stressed behavior) not evident in those injected with the S2 subunit. The S1 subunit localizes to the endothelia of microvessels in the mouse brain, and is a potent neurotoxin. So the spike S1 subunit of SARS-CoV-2 alone is capable of being endocytosed by ACE2 positive endothelia in both human and mouse brain, with a concomitant pauci-cellular microencephalitis that may be the basis for the neurologic complications of COVID-19. The Pfizer/BioNTech vaccine (BNT162b2) is composed of an mRNA that produces a membrane-anchored full-length spike protein. The mouse studies suggest that an untruncated form of the S1 protein like this may cause a microvasculopathy in tissues that express much ACE2 receptor. A truncated form of S1 was much less damaging in mice.
While there are pieces to this puzzle that have yet to be worked out, it appears that the viral spike protein that is the target of the major SARS-CoV-2 vaccines is also one of the key agents causing the damage to distant organs that may include the brain, heart, lung, and kidney. Before any of these vaccines are approved for widespread use in humans, it is important to assess in vaccinated subjects the effects of vaccination on the heart (perhaps using cardiac MRI, as Puntmann et al. did). Vaccinated patients could also be tested for distant tissue damage in deltoid area skin biopsies, as employed by Magro et al. As important as it is to quickly arrest the spread of the virus by immunizing the population, it would be vastly worse if hundreds of millions of people were to suffer long-lasting or even permanent damage to their brain or heart microvasculature as a result of failing to appreciate in the short-term an unintended effect of full-length spike protein-based vaccines on these other organs.
Particular caution will be required with regard to the potential widespread vaccination of children before there are any real data on the safety or effectiveness of these vaccines in pediatric trials that are only now beginning.PUBLIC SUBMISSION
Comment from J. Patrick Whelan MD PhD
Posted by the Food and Drug Administration on Dec 9, 2020
via a conversation on kitten corner: clinging to covid - by gatito bueno (substack.com): https://boriquagato.substack.com/p/kitten-corner-clinging-to-covid/comments#comment-9807663 Thanks for sharing!
The research trail showing harm with mRNA “vaccine” attempts was very clear. There were many warnings - this is being pushed through regardless. Latest tinfoil is that it is a Dept of Defense project all along, disguised as a pandemic solution in order to get the public to let themselves be injected with the nanochip/whatever it is biotechnology.
It is also clearly a computer-generated sequence forming a coronavirus spike that has many additional pathogenic sequences and is far more harmful than any other coronavirus spike - it has many species involved in addition to the group of coronavirus species. The pathology of the spike includes how it is broken down by our white blood cells - it is chopped into segments that maximize the prion like sequences and the protein bits form amyloid like tangles that are far denser and cannot be broken down by our normal fibrinogen mechanisms.
“Fibrinolytics to help break down fibrotic build-up before it is excessive may be helpful in inflammatory conditions and may be critical in CoV care. It has been found that our white blood cells break down the chimeric spike into seven prion-like domains, but our plasmin cannot break them down further like other amyloid proteins. (Nyström, et al, 2022) News article about the research: (Leifler, 2022). Serrapeptase, a silkworm fiber enzyme, may be helpful or others: nattokinase, bromelain, or lumbrokinase.” See this post: Endoplasmic Reticulum stress, misfolded proteins, allosteric modulators and delphinidin. (substack.com) The description of the segment’s shape reminded me of MC Escher’s tessellation art - Lego blocks that would stay together like puzzle pieces, forming a tighter complex:
I use serrapeptase on an empty stomach, once at night sometime. Serrapeptase is a silkworm enzyme and fibrinolytic. The biotech industry has had a lot of research regarding use of silkworm fiber in nanotech. If someone was designing an indestructible bioweapon for humans, than using silkworm fiber sequencing might have happened to. Nattokinase may be helpful too. Bromelain seems to help with nasal congestion more than my bad leg vessels (an old wound, is worse) We don’t know what we don’t know, but my health gets worse when I stop doing the extra self-care steps. This is serious.
This post has a section with possible therapeutics to use against the S1 subunit, in the second part, galantamine in addition to Nrf2 promoters, and “Tangent: “Cytisine and cytisine derivatives” may also be effective as a non-nicotine nAChR receptor agonist. (4)” I include a list of them with nutrients, a nucleotide, magnesium threonate, others:
Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
Reference List
(Leifler, 2022) Karin Söderlund Leifler, Possible discovery of mechanism behind mysterious COVID-19 symptoms. Linköping University, Medicalexpress.com, https://medicalxpress.com/news/2022-05-discovery-mechanism-mysterious-covid-symptoms.html
(Nyström, et al, 2022) Sofie Nyström et al, Amyloidogenesis of SARS-CoV-2 Spike Protein, Journal of the American Chemical Society (2022). DOI: 10.1021/jacs.2c03925 https://pubs.acs.org/doi/10.1021/jacs.2c03925
(Whelan, 2020) PUBLIC SUBMISSION, Comment from J. Patrick Whelan MD PhD, Posted by the Food and Drug Administration on Dec 9, 2020, https://www.regulations.gov/document/FDA-2020-N-1898-0246
I just started reading your wonderful work with the pomegranate article. This essay is of great value as it brings Dr. Whelan’s profound analysis and synthesis of the evidence at the time into the spotlight again — paired with your vital recommendations for potential harm reduction and remedy. Bless you for the discussion on supplements. Our rights to access supplements must be preserved from the likes of Senator Durban who is once again trying to move legislation to regulate supplements for our so called protection — an act of fatal paternalism that he tried over 20 years ago with Hilary (NY Senator). These foul efforts for Big Pharma were blocked by two bipartisan giants — Senators Harkin and Hatch who responded to the greatest public letter writing outcry known at the time. I had gotten one of Dr Mercola’s products lumbrokinase based on reading his blurb in a “read between the lines” fashion — he has also been a practical writer for remedies despite his ongoing persecution. Tip — look at what the FDA wants to ban in the supplements line. Dr Bhakdi’s very early videos decry in 2020 much of what Dr Whelan so beautifully presents evidentially regards vessel damage mechanisms at multiple dynamically cascading levels. But, Whelan’s citations are crucial and his suggestions for imaging and methods of demonstrating pathological processes are pure gold for scientific advancement. I am a clinical librarian-informationist and this essay demonstrated the value of the secondary literature, public commentary, and substack media to advance original synthesis to the community of interest. I didn’t really understand what was meant by “tin foil” label since I recently saw Bobby Kennedy’s interview on the CHD Chanel with Jeff Hayes on the new movie. Finally, I loved your in-text citation of the substack that advanced information for you. Nicely done citation reference— elegant scholarship in this publication format. 🥰 I am a big fan and will look for more of your potentially life saving essays. Thank you very much for your work and attention to old school standards.
Consider the protocols/advice we are given in Canada if we get infected, to stay at home and self-isolate. What about the elderly and people with co-morbidities? How are they to survive exposure to spike proteins? Microvasculature and fat tissue have the highest ACE-2 receptors, if we allow our entire microvasculature to become infected we can say goodbye to our li g term health. I lost 60 pounds of weight, exclusively in my adipose in just 60 days and doctors had no idea if or how it was connected to SARS-Cov-2 infection. Now we know that self isolation and doing nothing is a bad option that increases likelihood of morbidity and mortality.