Autophagy and NAD depletion

in other words - the niacin protocol helps promote autophagy

• “NAD exhaustion occurs due to hyperactivation of NAD-consuming enzymes.

• NAD-boosting agents rescue viability of autophagy-deficient human neurons.”

• Sun, et al. 2023, NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency, https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00383-2

• Quote of Tweet by agingdoc1: https://twitter.com/agingdoc1/status/1649730305937362946?s=20

NAD+ protective against aging; supplements discussed include “nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR)”, the niacin protocol would be providing NAD+ support too:

“In this review, we focus on the decrease in nicotinamide adenine dinucleotide (NAD+) with age and the supplementation of NAD+ precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR), in combination with other geroprotective compounds, to restore NAD+ levels present in youth.” (Sharma, et al., 2023)

• Sharma A, Chabloz S, Lapides RA, Roider E, Ewald CY. Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients. 2023; 15(2):445. https://doi.org/10.3390/nu15020445 https://www.mdpi.com/2072-6643/15/2/445

Hyperinflammation and EMF radiation toxicity are similar beasts - excess intracellular calcium causing too much activity and oxidative stress.

NADPH and NAD+ along with intermittent fasting and circadian health, in “How to treat EMF radiation - Part 2,” a post by Roman Shapoval:

How to treat EMF radiation - Part 2

Also helpful and on topic

SARS-CoV-2 and the importance of antioxidation

The high dose niacin protocol includes other mitochondrial support B vitamins and minerals and helps us by increasing both the removal of inflammation, released as the warmth of extra heat, and it helps promote endolysosomal removal of cellular debris - which is part of autophagy.

*This post had three topics and was getting delayed so I have removed two of the extraneous topics.

Niacin posts:

• Niacin protocol update & Vit C for heavy metal detox. Oct. 20, 2022, (substack.com)

• Niacin, & early treatment in general for SARS-CoV-2 is sensible, reduces hospitalization and mortality rate. Jan 22, 2021, (substack.com) *This has been my main Niacin protocol post.

• Niacin deficiency linked to glyphosate and cannibalism (in wild hamsters). Dec. 17, 2022, (substack.com) ***********This SEEMS IMPORTANT!

• Niacin and being a human knockout mouse. Sept 9, 2022, (substack.com) - addresses the effect of high dose niacin on serotonin levels - it is very important to be consistent with niacin dosing and to either increase or decrease the dosing over several days or weeks as suddenly stopping or starting can cause dramatic effects from a corresponding change in serotonin levels. The ‘human knockout mouse (me)’ post also mentions dimethylglycine may be helpful for preventing migraines too. Niacin may help prevent or treat migraines. - by Jenny {posts that say, by Jenny, are from transcendingsquare.com}, April 30, 2021, (substack.com)

• Niacin & fibromyalgia - victim of disinfo by the ChatGPT ; DrOpenAI also caught in a lie, MedPageToday article link. Jan 20, 2023, (substack.com)

• Mitochondrial dysfunction, continued, & an ASPEN webinar. Dec 7, 2022, (substack.com)

• Niacin - by Jenny, Aug 20, 2013, (substack.com)

*Correction - the melatonin made by our mitochondria occurs during the day and can be promoted by sunshine or infrared heat from the sun or other sources.

Glyphosate is bad for our microbiome and for us.

Some take home points -

• Intermittent Fasting can be as simple as trying not to snack in the evening and having a later breakfast in the morning. It helps give our body time to clean up cellular debris for reuse as nutrients. When we eat too much on average, our body is never given the time or need to scavenge for waste products that can be recycled as useful materials or broken down for energy and to be excreted.

• Niacin helps promote autophagy and inflammation removal and can help promote stable serotonin levels, and a better mood, when taken consistently.

• Melatonin can be used in larger amounts during the day but working towards a good night’s sleep and improved circadian cycle, with sunshine during the day and blackout level darkness at night, would be better for overall health.

• Glyphosate may be hugely significant in chronic illness and may be affecting mood too (the hamster info is disturbing). Why are so many more people committing violent acts? Maybe they are extremely deficient in important nutrients for a calm and happy mood.

Unrelated hamster photo. Gene editing is wrong, um kay.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.