Is taking trans resvetrol 100 mg/ d safe as antioxidant or is low dose a prooxidant? Protumor? Proestrogen etcetc
I started it this week adding to other antioxidants intake but wonder if should stop after reading this?!
What do yr studies show?
"A study carried out by Martins et al. revealed that resveratrol can modulate different pathways at a time, which can result in distinct and even opposite biological effects, depending on its concentration or treatment time defined. The authors documented that, although a dose-dependent resveratrol pro-oxidative effect leads to cells oxidative stress over lesser time exposure, at same dose but with an increase in exposure time, less expressive cytotoxicity was found. This suggest that surviving cells seemed to be more resistant to resveratrol-induced damages, being its effects attenuated over treatment time [114]. Additionally, low resveratrol doses (0.1–1.0 μg/mL) has been documented to enhance cell proliferation, whereas higher doses (10.0–100.0 μg/mL) induces apoptosis (Figure 2) and decreases mitotic activity on human tumors and endothelial cells [122]. Recently, dual resveratrol pattern effects on HT-29 colon cancer cells death and proliferation were observed, where at low concentrations (1 and 10 μmol/L), resveratrol increased cells number, while at higher doses (50 or 100 μmol/L) resveratrol reduced cells number and increased apoptotic or necrotic cells percentage [123]
There is an interesting correlation among dietary polyphenols pro-oxidant and cytotoxic activities, such as to resveratrol. In fact, since every antioxidant is a redox agent it might become a pro-oxidant, accelerating lipid peroxidation and/or inducing DNA damages under special conditions. In this way, it has been proposed that such pro-oxidant action could be an important mechanism of action to resveratrol anti-cancer and apoptotic-inducing properties [112]. It has already been reported that resveratrol can lead to DNA damages, as well as to a reversible or irreversible cell cycle interruption mediated by its pro-oxidant effect [117]. Recently, Plauth et al. [125] proposed that cellular response to resveratrol treatment is based on oxidative triggering action, that can lead to cell fitness hormetic induction towards a more reductive state, so as to physiological resilience raising in fight oxidative stress. Also, it has been reported earlier that a critical balance between intracellular hydrogen peroxide (H2O2) and O2– decides cells fate to ...
Besides, in absence of estrogen (E2), resveratrol exerts mixed estrogen agonist/antagonist activities in some mammary cancer cell lines, but in the presence of E2, resveratrol acts as an anti-estrogen [134]. In another report, it was demonstrated that resveratrol abolishes serum deprivation-induced elevated caspase 3 activity, suggesting its rescue effect via p38 MAPK signaling [135]. Resveratrol also regulates mitochondrial respiratory chain function, with mitochondrial complex I (CI) as a direct target of this molecule. It was also in vivo demonstrated that, in young and old mice brain mitochondria, resveratrol increased CI, while in aged animals with low antioxidant defenses led to oxidative stress. Therefore, not only dose, but also age at the time of treatment, can modulate intracellular and mitochondrial redox status, switching from resveratrol beneficial to deleterious effects, highlighting the importance of a balance between resveratrol pro- and antioxidant effects, that depends on its dose and age as well [136]. Yang et al. [137] reported dual resveratrol roles in pancreatic cancer cells: one as a tumor suppressor through Bax up-regulation, and the other one as a tumor activator through VEGF-B up-regulation; so, resveratrol anticancer effect is much stronger than cancer promotion effect.
All the above highlighted studies show the pivotal role of dose-dependency and aging in resveratrol-induced responses towards health benefits. Also, in another study, aiming to compare resveratrol effects on aging-induced and re-nutrition-induced insulin resistance and its consequences on arterial system, the authors found that resveratrol improved insulin sensitivity in old mice fed standard diet, while did not improve insulin resistance status in old mice receiving high-protein diets. In contrast, resveratrol exhibited deleterious effects by increasing inflammation state and superoxide production and decreasing aortic distensibility. This data demonstrates that resveratrol seemed to be beneficial to malnourished state of physiological aging, whereas when associated with high protein diets in old mice, may increase atherogenesis-associated risk factors by triggering vascular alterations that could represent an additional risk factor for cardiovascular system
In vitamin C the pro-oxidant concern is more with the high dose trend - for cancer or cytokine storm, not as a preventative - there it would be too much and maybe pro-oxidant. With resveratrol being somewhat hormonal in effects the dosing range would be narrow.
Questions I would ask / or suggestions - do you notice a beneficial effect on your health? Test is individually as the only new thing and see how you feel. Go without a few weeks and see if you feel worse... clinical trial of your own, as a self-controlled study format. If you overall are already healthy you may not need as much as someone with Long Illness of some sort.
Based on product search - 100 mg is the low-end dose available and 1200 mg the high end. https://consumershealth.org/resveratrol-supplements-guide/?msclkid=a529c7809f9b14650886a423aa74ee2d I would think you would be fine. I have used a low end dose (the stuff is pricy) but I don't remember what it was. Because of the price it isn't one that I take all of the time, more like pick up a bottle occasionally and use the bottle up.
Question oh wise one!
Is taking trans resvetrol 100 mg/ d safe as antioxidant or is low dose a prooxidant? Protumor? Proestrogen etcetc
I started it this week adding to other antioxidants intake but wonder if should stop after reading this?!
What do yr studies show?
"A study carried out by Martins et al. revealed that resveratrol can modulate different pathways at a time, which can result in distinct and even opposite biological effects, depending on its concentration or treatment time defined. The authors documented that, although a dose-dependent resveratrol pro-oxidative effect leads to cells oxidative stress over lesser time exposure, at same dose but with an increase in exposure time, less expressive cytotoxicity was found. This suggest that surviving cells seemed to be more resistant to resveratrol-induced damages, being its effects attenuated over treatment time [114]. Additionally, low resveratrol doses (0.1–1.0 μg/mL) has been documented to enhance cell proliferation, whereas higher doses (10.0–100.0 μg/mL) induces apoptosis (Figure 2) and decreases mitotic activity on human tumors and endothelial cells [122]. Recently, dual resveratrol pattern effects on HT-29 colon cancer cells death and proliferation were observed, where at low concentrations (1 and 10 μmol/L), resveratrol increased cells number, while at higher doses (50 or 100 μmol/L) resveratrol reduced cells number and increased apoptotic or necrotic cells percentage [123]
There is an interesting correlation among dietary polyphenols pro-oxidant and cytotoxic activities, such as to resveratrol. In fact, since every antioxidant is a redox agent it might become a pro-oxidant, accelerating lipid peroxidation and/or inducing DNA damages under special conditions. In this way, it has been proposed that such pro-oxidant action could be an important mechanism of action to resveratrol anti-cancer and apoptotic-inducing properties [112]. It has already been reported that resveratrol can lead to DNA damages, as well as to a reversible or irreversible cell cycle interruption mediated by its pro-oxidant effect [117]. Recently, Plauth et al. [125] proposed that cellular response to resveratrol treatment is based on oxidative triggering action, that can lead to cell fitness hormetic induction towards a more reductive state, so as to physiological resilience raising in fight oxidative stress. Also, it has been reported earlier that a critical balance between intracellular hydrogen peroxide (H2O2) and O2– decides cells fate to ...
Besides, in absence of estrogen (E2), resveratrol exerts mixed estrogen agonist/antagonist activities in some mammary cancer cell lines, but in the presence of E2, resveratrol acts as an anti-estrogen [134]. In another report, it was demonstrated that resveratrol abolishes serum deprivation-induced elevated caspase 3 activity, suggesting its rescue effect via p38 MAPK signaling [135]. Resveratrol also regulates mitochondrial respiratory chain function, with mitochondrial complex I (CI) as a direct target of this molecule. It was also in vivo demonstrated that, in young and old mice brain mitochondria, resveratrol increased CI, while in aged animals with low antioxidant defenses led to oxidative stress. Therefore, not only dose, but also age at the time of treatment, can modulate intracellular and mitochondrial redox status, switching from resveratrol beneficial to deleterious effects, highlighting the importance of a balance between resveratrol pro- and antioxidant effects, that depends on its dose and age as well [136]. Yang et al. [137] reported dual resveratrol roles in pancreatic cancer cells: one as a tumor suppressor through Bax up-regulation, and the other one as a tumor activator through VEGF-B up-regulation; so, resveratrol anticancer effect is much stronger than cancer promotion effect.
All the above highlighted studies show the pivotal role of dose-dependency and aging in resveratrol-induced responses towards health benefits. Also, in another study, aiming to compare resveratrol effects on aging-induced and re-nutrition-induced insulin resistance and its consequences on arterial system, the authors found that resveratrol improved insulin sensitivity in old mice fed standard diet, while did not improve insulin resistance status in old mice receiving high-protein diets. In contrast, resveratrol exhibited deleterious effects by increasing inflammation state and superoxide production and decreasing aortic distensibility. This data demonstrates that resveratrol seemed to be beneficial to malnourished state of physiological aging, whereas when associated with high protein diets in old mice, may increase atherogenesis-associated risk factors by triggering vascular alterations that could represent an additional risk factor for cardiovascular system
In vitamin C the pro-oxidant concern is more with the high dose trend - for cancer or cytokine storm, not as a preventative - there it would be too much and maybe pro-oxidant. With resveratrol being somewhat hormonal in effects the dosing range would be narrow.
What might we get in the diet? Not much: "Red wines have a resveratrol content (per 5-oz glass) of 0.03-1.07 mg in contrast to the 0.01-0.27 mg for white wines. Red grape juice contains 0.017-1.30 mg per 5 oz." https://www.news-medical.net/health/Resveratrol-in-Wines-and-Grapes.aspx
Questions I would ask / or suggestions - do you notice a beneficial effect on your health? Test is individually as the only new thing and see how you feel. Go without a few weeks and see if you feel worse... clinical trial of your own, as a self-controlled study format. If you overall are already healthy you may not need as much as someone with Long Illness of some sort.
Based on product search - 100 mg is the low-end dose available and 1200 mg the high end. https://consumershealth.org/resveratrol-supplements-guide/?msclkid=a529c7809f9b14650886a423aa74ee2d I would think you would be fine. I have used a low end dose (the stuff is pricy) but I don't remember what it was. Because of the price it isn't one that I take all of the time, more like pick up a bottle occasionally and use the bottle up.
Oops realized its 40 mg trans resvetrol and 40 Vit c per capsule
Would ditch it if no benefit n may worsen things!
Started q 10 100mg and hope all these " natural" drugs don't have untoward effects too
Glad in Canada we have stricter guidelines with NPN numbers on bottles but ya never know:)