Part 4. modRNA, pseudouridine, snoRNA; Cancer, CoV, microRNA, mRNA
CoV jabs are bad, um kay!
Um Kay? The Southpark cartoon guidance counselor would say “Drugs are bad, um Kay”. Nuff said, just the ultimate bad, like Nancy Reagan said “Don’t do drugs”. Of course many people and kids want to do the exact opposite of whatever they were flatly ordered to do or to not do. Being a guidance counselor is a tough tight rope walk, balancing between giving motivating carrots of positives to work for and look forward too, and use of a donkey prod of negative risks to avoid.
“Messing around with pseudo-U modified micro RNAs can give you cancer.
Don't do it.” - JikkyLeaks, April 30, 2023, (Twitter)
The CoV jabs are sooooooooooo bad that prior health issues pale in comparison. Yet, we can learn from them - the prior health issues and research. We need to also dig into what the CoV mRNA and LNPs and adjuvant, and contaminants, do to people AND we need to dig into the standard health problems of our times and compare them to older times, because people are sick in part because they already were sick.
Other elite athletes weren't sick but died anyway, sooooooooooo, we need to understand all of the problems piled on us if we hope to keep digging the manure out of the stable stall every day. We also have to stop adding to it 💩, and that means we NEED to understand what is adding to chronic inflammation from modern life and modern habits. Inflammation - modern fires of physical and emotional stress.
The deep dive into microRNA-21 did reveal significant dietary and lifestyle factors that affect the expression of miR-21. High glucose levels or saturated fat levels (palmitate specifically) affect expression of miR-21 and the palmitate is more likely to become elevated from endogenous production from overeating calories and carbohydrates combined with a sedentary lifestyle.
We also learned the basics of some types of RNA. MicroRNA regulate mRNA, basic rule of how it all works…
…until the CoV mRNA, AND any other similar ‘therapy’ products. Pseudouridine was used to replace 100% of the uridine to make the injection mRNA last longer in the body - which isn't normal so we can't break it down normally. (Lockhart, et al., 2019)
modRNA - modified RNA has Pseudouridine replacing the normal uridine. Protein transcription may be more efficient but normal silencing with a microRNA switch may no longer work. Where in the RNA sequence the pseudouridine is located (at the 3’ UTR site versus the 5’ UTR site - at the beginning or at the end) makes a difference on the silencing error - at the 5’ end would still allow the miRNA silencing of the mRNA. (I think.)
“In this study, we sought to investigate the influence of modified nucleotides on the performance of miRNA switches. We found that the incorporations of Ψ and m1Ψ, which increase translation, tend to decrease the miRNA-dependent regulation of miRNA switches, while Ψ/m5C modification enables one miRNA target site at the 3′ UTR to regulate the miRNA switch as effectively as four target sites. We also demonstrated that the effects of Ψ, Ψ/m5C, and m1Ψ modifications are sequence dependent and are not correlated with the proportion of modified nucleotides in the miRNA target site. Furthermore, modified miRNA switches containing seed-complementary target sites are poorly regulated by miRNA, while placing the miRNA target site in the 5′ UTR makes the miRNA-dependent silencing largely insensitive to nucleotide modification (Table S2).”
The three dimensional shape of the modified RNA is changed, making the miRNA target sites no longer a perfect fit. Complementary microRNA is needed to regulate a messengerRNA - a perfect match, not just any old tiny RNA fragment.
“Nucleotide modification alters the secondary or tertiary structure of the mRNA,35 which may alter accessibility of the miRNA target sites in a switch-specific manner. In fact, Ψ modification has been reported to reduce protein binding to consensus sequences in mRNA.36” (Lockhart, et al., 2019)
microRNA can't regulate modified RNA properly - can't start the breakdown process. It seems foreign. It is seen as a substitution for uridine in RNA within normal physiology, but only at a rate in the 1-2% or less, my digits might be off, 0.1-0.2%?, - but nowhere near 100% substitution. (Lockhart, et al., 2019)
The mRNA therapy method itself is dangerous, chimeric spike just makes it worse. The autoimmune and pseudouridine concerns (Lockhart, et al., 2019) would be present with any other gene sequence than the chimeric spike.
Autoimmune aspect: IgG4 antibodies - the autoimmune kind we don't want, are elevated by increasing # of CoV jabs. Passive exposure is likely similar. 27 Dec 2022, (substack.com)
Elevated IgG4 ~> VAIDS/ a preprint; Flavonoids -> let nature do the microbiology. 29 March 2023 (substack.com)
What autoimmune hyperinflammation looks like - LongCovid/FLCCC Conference. 22 Oct 2022, (substack.com)
The mRNA ‘vaccine’ methodology is in itself dangerous but is being approved anyway.
Five mRNA injections have been approved worldwide for use against CoV and more are in development stages for CoV or other uses. (VFA)
Addition: a summary of potential misdeeds on Comirnity clinical trials:
“Danger, danger, Wil Robinson.” - Lost in Space, old TV series.
This is how many mRNA vaccines are being developed, 29, April, 2023 | VFA, mRNA vaccines for vaccinations, “So far, five mRNA vaccines have been approved worldwide for vaccination against Covid-19, two of them in the EU. Many more are in development, also against other diseases.” *autotranslation from German.
…and the Pseudouridine substitution adds a cancer risk, and the DNA plasmids do to.
Can we feasibly fight it?
Basic fact of life: Not trying won't help much.
Little motto - Not trying is dying - not moving is signaling to our mitochondria that we are no longer a viable moving organism and that seems to add to cellular dysfunction. We need to keep moving to keep signaling to our symbionts that we are a functioning team - let’s keep all working together in harmony. Repair and growth signals need to be more numerous than breakdown/decoposition or autoimmune self-death signals.
“And sunshine”, a Comment, and link, Roman Shapoval. Thanks, great article! Yes, Circadian Cycle health is a need that modern life makes hard to achieve.
Avoid spike List:
No more jabs, reduce passive exposure, use negative ionizers for air sterility of the positively charged spike, intranasal rinse or sprays can help after being out. KN95 masks have seemed to reduce flair-ups for me if I have to go to medical settings or busy small poorly ventilated places.
Ongoing “Boosters” via passive exposure seem to increase the allergy like sensitization to chimeric spike, at least for some people. Relapses for me 2021, would hit harder and stay longer, so I stopped going out as much and now also have to avoid getting too tired or overworked or shingles may appear. The gift of VAIDS is a chronic thing - like a weakness seems to be present now.
Autoimmune reactions are set up against cells with spike on them - body killing self or gut microbes killing themselves.
In the gut microbiome, the bacteria have been found to self-kill rather than grow tge spike protein from an LNP or DNA plasmids. Mercy self-death is nature’s way for bacteria to prevent themselves from being hijacked to make a foreign protein.
And that is not a bad thing, we don't want more spike factories producing spike - or other bacterial species from incorporating the gene sequence into a new wild type chimeric organism. WE REALLY DON’T WANT THAT.
So, replenishing the microbiome is a daily need: zinc, resistant starches, moderate regular exercise, good hydration.
Other needs: Avoiding spike is a daily need, and avoid stress, and avoid saturated fat above 10% of the total calories, and avoid overeating total calories or a larger ratio of carbohydrates - which may include the standard diet of 50-55% carbs. I aim for a 30% calories from carbs diet, limited saturated fats from coconut, and extra fat calories from nuts and seeds and avocado, and 20-25% protein.
Have adequate or extra methyl B12, folate, choline, and other B vitamins. High dose niacin protocol can help the body remove cellular debris and inflammation.
Promote autophagy - cellular debris cleanup - by not over-eating routinely, increasing the number of hours without food in a 24 hour period for a gut rest at night - intermittent fasting by not snacking in the evening and having a late breakfast. Reducing carb use during those hours can be a substitute if some food is needed for mood support.
Gentle full range body movement and good hydration helps clear out lymphatic fluid throughout the body and remind mitochondria throughout the body that we need and value them working efficiently every day.
More RNA glossary: SnoRNA ❄️, tRNA, rRNA, and modRNA
snoRNA - small nucleolar RNA
“Small nucleolar RNAs (snoRNAs), a type of non-coding RNA, are widely present in the nucleoli of eukaryotic cells and play an important role in rRNA modification. With the recent increase in research on snoRNAs, new evidence has emerged indicating that snoRNAs also participate in tRNA and mRNA modification. Studies suggest that numerous snoRNAs, including tumor-promoting and tumor-suppressing snoRNAs, are not only dysregulated in tumors but also show associations with clinical prognosis.” (Huang, et al., 2022)
tRNA - transfer RNA - a small segment of RNA which assures that it is the correct amino acid being added to a growing protein chain being transcribed by a ribosome from a messenger, mRNA. So, the tRNA are a quality control step in protein production. (genome.gov/genetics-glossary/Transfer-RNA)
rRNA - ribosomal RNA
“Ribosomal RNA is the major structural component of the ribosome and has sequence complementarity to regions of mRNA with which it can interact. Ribosomes are assembled in the nucleolus, a distinctive structure in the nucleus of a eukaryotic cell that serves as a factory for ribosomes, tRNAs, and various noncoding RNAs. The nucleolus is also the assembly site for telomerase and other RNA–protein complexes. Ribosomes are a complex of up to 80 ribosomal proteins, which are synthesized in the cytoplasm and transported into the nucleus for assembly, and several different ribosomal RNA molecules, three in prokaryotic ribosomes and four in eukaryotic ribosomes.” -
RNA and Protein Synthesis, N.V. Bhagavan, Chung-Eun Ha, in Essentials of Medical Biochemistry (Second Edition), 2015, Viewable at (ScienceDirect)
modRNA - modified RNA has Pseudouridine replacing the normal uridine. Discussed earlier in the post. (Lockhart, et al., 2019)
Why do I bother? Why do I make long reference lists? because I need to learn how to use a citation manager maybe, or because the Harvard citation style really does make it easier to remember a research article and to cite it properly. Also, saving links someone else found can save time and pad a non-existent budget. Most of the links from Annoyed Citizen’s lengthy post are fulltext, no paywall → good finds. It will take me time to look closer than skimming the abstracts. As a general rule I do not buy research articles that have a paywall, because once started, where would I stop? So, I just don’t, I look for other articles on the topic and rarely will buy an article that seems important. It costs money to do research even if you aren’t running clinical trials. People with a university affiliation likely get access to any journals or sites that the university pays for.
Why do I bother part 2? The value of a multi-disciplinary team is to get different sets of eyes on the minutia. The nutrition aspects stand out to me - from the sea of mind-boggling minutia - yes, this stuff is complicated - BUT - the miracle of life is a miracle - it works, and it works in a lot of different species - SOOOOOOOO what is it that humans have got wrong? …. That is a long list - and in part, being lazy and eating too much is a negative. But, the food supply is rigged against us, and many medications including the CoV injections and any other mRNA ‘therapies’ that are going to be proposed.
We need to collectively fight this. No more boosters, no more mystery injections. We have no idea what level of contamination all the other jabs have had all along - the writing on the wall suggests - it has been bad anyway. The mRNA and Lipid Nanoparticles are just worse.
“Messing around with pseudo-U modified micro RNAs can give you cancer.
Don't do it.” - JikkyLeaks, April 30, 2023, (Twitter)
Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
(Huang, et al., 2022) Huang, Zh., Du, Yp., Wen, Jt. et al. snoRNAs: functions and mechanisms in biological processes, and roles in tumor pathophysiology. Cell Death Discov. 8, 259 (2022). https://doi.org/10.1038/s41420-022-01056-8 https://www.nature.com/articles/s41420-022-01056-8
(Lockhart, et al., 2019) Lockhart J, Canfield J, Mong EF, VanWye J, Totary-Jain H. Nucleotide Modification Alters MicroRNA-Dependent Silencing of MicroRNA Switches. Mol Ther Nucleic Acids. 2019 Mar 1;14:339-350. doi: 10.1016/j.omtn.2018.12.007. Epub 2018 Dec 18. PMID: 30665183; PMCID: PMC6350232. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350232/
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