nAChRs - lengthy; nattokinase, brief; and Katherine Watt and Laura Jeffery interviews.
Post too long for email.
Briefly regarding nattokinase. I saw a Tweet complaining about health strategies, tired of it all. Took nattokinase for a year and hasn't seemed to help - still feel unwell/lingering symptoms after CoV or jabs, I am not sure.
Yes - autoimmune disease is bad and chronically not feeling well is kind ofvthe norm. It is the good days that become unusual. Taking nattokinase for a year probably helped, just not enough. My lists are long because the body needs a lot of help against inflammation and autoimmune over-reactivity. Avoiding the toxin is critical - or blocking or removing it promptly with improved detox habits and support.
The other point to notice - is “one year” - in that year, a sudden death didn't ocvur and while “improvement” might have been minimal - that is not the same as worse or severely worse.
When prevention works it can seem like nothing happened AND that is the goal - prevent something bad from happening.
If frustrated about taking something long term, take a pause - stop use gradually depending on the item, and see if your symptoms worsen. If they do, start use again - it was helping.
Motivator:
I take nattokinase or serrapeptase every night, sometime when I wake up. I have an old leg wound that has gotten worse, but going without the fibrinolytic makes it much worse, limping level worse. I prefer not limping. That may just be me, but I bet others also prefer walking normally.
Video testimony by Laura Jeffery
Laura Jeffery is an embalmer whistleblower who saw the fibrous clots become a more and more obvious problem as the jab season progressed from spring 2021 to later in the year. It took time for the clot things to become really large - those were late in the year. The first one she saw was only 3-4 inches long. Images shared by another embalmer are included in the video. The problem is not unique to her work, another funeral embalmer has spoken out about the odd fibrous masses. The fibrous masses have to be physically pulled out throughout the whole body for embalming fluid to be used. Their work started taking twice as long. She also noticed an increase in sudden deaths and a lack of autopsies being performed. Normally any unusual death will lead to an autopsy. There was also a change in the number of deaths of babies from about 2-5 per month, varied stages of gestation and then no babies after ~ February 2021, and ongoing, ever since. Other funeral directors at small communities saw an increase in baby losses. Small hospitals versus large ones instruct patients who lost a baby with differing guidance - use of a funeral home or the hospital morgue.
[*NaChRs are involved in implantation and fetal development, so early miscarriages are likely related, more later in the post. Cholinergic blocking would then prevent a fertilized ovum from implanting properly in the uterus.]
Licensed Funeral Director Laura Jeffery on Post-Vaccine Embalming | NCI, NationalCitizensInquiry.ca https://rumble.com/v2fuj08-licensed-funeral-director-laura-jeffery-on-post-vaccine-embalming-nci.html
Fibrotic inflammation takes time to build up and it takes time to prevent it from building up.
»This is a US Department of Defense biological ‘prototype’/ aka experimental bioweapon, and the entire population was made into a target group for testing the experiment.
Video by Katherine Watt - how the US changed laws to make the entire population a target for experimental military biological prototypes.
Related posts on nAChRs
Respiratory impacts
Cholinergic inhibition and breathing. (substack.com), excerpt:
“Activation of Nicotinic Cholinergic Receptors Prevents Ventilator-Induced Lung Injury in Rats” (Bregeon, et al., 2011) […] Coincidentally nAChRs have a regulatory role over respiration pattern - the rhythm of our breathing. (Shao, Feldman, 2009) Interesting factoids interest me. Alpha -7-nAChrs have a regulatory role over inspiratory contractions of the diaphragm muscle. (Dehkordi, et al., 2004) Another #Coincidence.
“These findings suggest that nicotinic cholinergic regulation of the chest wall pumping muscles may occur at multiple levels of the central nervous system.” (Dehkordi, et al., 2004)
Cholinergic blocking toxins like Conotoxin and snake venom toxin are used as paralytics because they are cholinergic inhibitors of nAChRs. Generally, not a good thing for health.
A study found that the original SARS-CoV-2 spike, S1 and S2 did not affect nAChRs -https://www.pnas.org/doi/10.1073/pnas.2204242119 however the injection version is different and is when we first heard of passive exposure leading to menstrual irregularities even in post-menopausal or pre-menstruation age females (girls and babies).
Cardiovascular/myocarditis impacts
and this post: Catecholamine-mediated stress myocarditis, spike S1 and alpha 7 nAChRs. Can we please talk about solutions yet? Nicotine lozenges are one, and I linked to more in this older post. (substack.com)
Amyloidosis was reduced by C60, Fullerene - an Nrf2 promoter in antioxidant form. (substack.com) excerpt:
Agonist for nAChRs: Galantamine - from snow drop flowers
Galantamine to increase acetylcholine levels
Two major clinical studies in people with Alzheimer's have achieved rapid and dramatic improvements in memory, learning, as well as cognitive and behavioral gains. Indeed, galantamine, perfectly tolerated, slows down the deterioration of cognitive and functional abilities by:
Inhibit acetylcholinesterase and therefore increase acetylcholine levels.
Stimulate the action of acetylcholine in its brain receptors.
Allow a better cerebral blood supply, thus improving cognitive performance.
Stimulate, like tobacco, certain specific receptors in the brain, the alpha-7 nicotinic receptors, thus improving learning, memory, attention and concentration.
For more than twenty years, Galantamine has aroused great interest throughout the world and is indicated in the United States for Alzheimer's patients, where it is also authorized for this indication by the Food and Drug Administration (FDA). (3)
Possible agonists - cytisine and cytisine derivatives.
Tangent: “Cytisine and cytisine derivatives” may also be effective as a non-nicotine nAChR receptor agonist. (4)
I don't like the Count the Miscarriage/dead babies game. Let's do something helpful instead. (substack.com), excerpt:
Impacts of alpha 7 nAChRs in prenatal development / complications.
This one is about pre-eclampsia placental abnormalities (less alpha 7 nAChR function). Stimulation of α7 Nicotinic Acetylcholine Receptor by Nicotine Suppresses Decidual M1 Macrophage Polarization Against Inflammation in Lipopolysaccharide-Induced Preeclampsia-Like Mouse Model. (Han, et al., 2021)
This one compares several conditions and the placenta health/abnormalities of the pregnant subjects. Immunohistochemical Expression of the Alpha Nicotinic Acetylcholine Receptor 7 in the Human Normal, Diabetic, and Preeclamptic Placenta and Products of Conception. (Alwazzan, et al., 2020)
This one is about the alpha 7 nAChR in fetal brain and spinal cord development. Toxin-like peptides in plasma, urine and faecal samples from COVID-19 patients. (Brogna, et al., 2021)
Conotoxin (marine snail toxin similar to snake venom toxin) specifically blocks the alpha 7 nAChR making it easier to research the function of that specific one. The spike chimera is not 'snake venom toxin' it has a similar phenotype, similar effects. Conotoxin like chemicals were identified in samples from COVID19 patients but not the control group. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772524/
Excerpt from post/later half of the post: "A positive correlation between the number of vaccine doses and [infant mortality rates] IMRs is detectable in the most highly developed nations..." (substack.com)
*also related posts:
S1 jab version may be different imo than SARS-CoV-2 version. /link to Unglossed-Brian Mowrey (substack.com)
S1 spike found in autopsy, not the viral Nucleocapsid protein. (substack.com)
The jab version RNA sequences are “noticeably different” from the SARS-CoV-2 infection version of the chimeric spike as shown in a computer analysis by (McKernan, Kyriakopoulos, McCullough, date)
Not knowing anything about what the RNA folding maps mean - we can see that they do look quite different (below). The first two are the Moderna and Pfizer jab sequences and the third is the infection SARS-CoV2 version - it does look more fractal and natural somewhat than the linear jab version’s image, below.
“Figure 2. The three different Spike Protein Sequences (Moderna (left), Pfizer (middle), SARsCoV-2 (right) analyzed with RNAfold.” (McKernan, Kyriakopoulos, McCullough, date)
Looking at any research I can find about nAChRs and excessive menstrual bleeding… nicotine in excess, with tobacco smoking, may lead to infertility by activation of alpha-7 nicotinic acetylcholine receptor which inhibits GnRH release (in vitro studies). (Messi, et al., 2018) Gonadotropin-releasing hormone (GnRH) is a key regulator of the female hormone cycle and regulator of the hypothalamus-pituitary-gonadal axis. It also has a role in suppressing endometrial stem cells - a negative for this research team’s focus on invitro-fertilization. (Park, et al., 2018) However - if activation of the alpha-7 nicotinic acetylcholine receptor is needed to SUPPRESS endometrial stem cells - then inhibition of them might lead to excessive endometrial production - aka, excessive menstrual bleeding. It makes sense that the body has a method to suppress endometrial stem cells for infants, girls and post-menopausal women.
“Therefore, we hypothesized that long-term GnRH exposure directly damages endometrial stem cells and consequently negatively affects pregnancy outcomes in GnRH-based IVF. In addition to their well-known roles in regulating the hypothalamus-pituitary-gonadal axis, GnRH and its receptors also localize in the extra-hypothalamic endometrium, suggesting a possible non-canonical role in endometrial stem cells. Consistent with our hypothesis, we show for the first time that GnRH suppresses the multiple beneficial functions of endometrial stem cells via the PI3K/Akt signaling pathway in vitro and in vivo.” (Park, et al., 2018)
The effects of LPS endotoxin on the hypothalamus-pituitary-gonadal axis is a theory proposed by Geoff Pain to explain the excessive menstrual bleeding seen after the CoV jabs; in this post, Extreme Toxicity of Endotoxins in Pfizer Jabs, Geoff Pai PhD, (substack.com):
Excerpt from Geoff’s post:
“Endotoxin induces Nitric Oxide formation 12 and Prostaglandin synthesis providing clues to systemic Hormone disruption observed with Covid19 jabs. 13
Prostaglandins are part of the Hypothalamic–Pituitary–Gonadal (HPG) axis which is primarily responsible for regulating reproductive activity and the release of ovarian hormones in animals and humans. 14
Prostaglandins are responsible for uterine contractions during menstruation.”
- Geoff Pain PhD, Extreme Toxicity of Endotoxins in Pfizer Jabs (substack.com)
And alpha-7 nicotinic acetylcholine receptors have regulatory control or effects on the hypothalamus-pituitary-gonadal axis. (Park, et al., 2018)
Which came first? The choline/nicotine agonist or the prostaglandins? When receptors have regulatory control than either a lack of the agonist or an excess might cause similar dysfunction. Regulatory balance was lost.
The flaw in the LPS theory is the question of why would women or girls, who were simply exposed to other people who got CoV jabs, be getting excessive menstrual symptoms too? The LPS is not a sequence in the chimeric spike protein as I understand it. But may be added to ‘vaccines’ as an ‘adjuvant’ - a toxin purposely added to a jab to promote a strong reaction from the immune system. Calcium could be used more safely. Vaccines are not what they were initially, anymore, just a sample of the weakened pathogen to initiate an immune response without a full illness.
There are unknowns here, but what is known is that being a smoker seems to have a protective effect rather than the expected increased risk for a “respiratory” infection. I put respiratory in quotes because it turns out that SARS-CoV-2/CoV jab spike is an endothelial infection, not just respiratory.
Potentially related: The use of a ‘trojan’ vaccine to cause infertility has already happened in Kenya. Catholic priests had independent testing done and HCG was found in alleged DTaP vaccines. The Kenyan government was found to be complicit, to know the vaccines were doing another job. HCG Found in WHO Tetanus Vaccine in Kenya Raises Concern in the Developing World (Oller, et al., 2017) https://www.scirp.org/journal/paperinformation.aspx?paperid=81838
What is known about “excessive menstrual bleeding” with a change in hormone balance - is that it had been associated with early onset infertility.
Effects from Cholinergic blocking are throughout the body.
Earlier sections of this post included: Respiratory, cardiovascular, prenatal/embryo and fetal development. More about the prenatal/fetal role is in this article, (Broide, et al., 2019), excerpt:
“The results suggest that prenatal nicotine exposure could potentially affect the nervous system with limited effects in non-neural tissues.” […]
“For a long time, the consensus was that neuronal nAChRs are expressed exclusively on neurons. However, in recent years it has become increasingly clear that functional nAChR responses can be found in non-excitable cells, including microglia (Shytle et al., 2004; Suzuki et al., 2006), astrocytes (Papouin et al., 2017), Schwann cells (Petrov et al., 2014), and other non-neuronal tissues (Sharma and Vijayaraghavan, 2002), and that these responses are often mediated by α7 nAChRs. Of particular interest is the expression of α7 nAChRs in the immune system, because of its crucial role in the regulation of the cholinergic anti-inflammatory pathway (Wang et al., 2003). Based on findings from previous studies, neuronal nAChR subunits appear early during brain development (Zoli et al., 1995; Adams et al., 2002; Tribollet et al., 2004).”
Distribution of α7 Nicotinic Acetylcholine Receptor Subunit mRNA in the Developing Mouse, (Broide, et al., 2019)
The results of the study on distribution of α7 Nicotinic Acetylcholine Receptor Subunit mRNA in a developing mouse, also suggest that prenatal cholinergic blocking by a conotoxin like substance would cause significant negative impacts on the fetus and viability of a pregnancy. When something has a regulatory role, either too much or too little of the action will cause similar dysfunction - that system cannot be regulated properly with either too much or too little of the function.
The thing to remember about “addiction” is that if we need something to function better, then we will crave it and seek it out, possibly desperately. I am addicted to oxygen and really like to get plenty within every five minutes of my entire lifespan. I am a real big fan of water too and like to get some every hour or so and have a glass by my bed to sip occasionally at night.
Some addictions serve no significant purpose beyond a temporary dopamine rush, like buying more shoes or fashion or art or sports cars or whatever - that is an addictive shopping habit or hoarding problem.
We aren’t supposed to talk about nicotine in relation to chimeric spike or CoV ab issues and most of the alternative ‘voices’ are going along with that. Either they don’t understand the cholinergic system, which seems unlikely, or something else is going on. Ask why really smart scientists don’t seem to understand the importance of the cholinergic system. The nicotinic Acetylcholine receptors are a specific type of receptor within the cholinergic system. Conotoxin and snake venom toxins target them fairly specifically making short term anesthesia possible when used in limited amounts.
“The importance of the nAChR cannot be underestimated, for it is through the manipulation of this receptor that many anesthetic goals are achieved.” (Rossman, 2011)
If the body is producing an nAChR paralytic toxin, daily, then the paralysis effect on the body will be daily, not limited to a few hours during a monitored surgery. It might lead to myocarditis, reduced respiration, prenatal complications, and colitis. (Zheng, et al., 2021)
Personally, I don’t like colitis - it can kill you too, from dehydration and malnourishment. It also just hurts. Irritable Bowel Syndrome is irritating - rush to the bathroom, but is not as severe of inflammation and doesn’t usually cause and aching gut all day. I did start using nicotine lozenges again and it did seem to help my gut feel less in pain. The butyrate producing tapioca pudding helped too though. Our bodies need many things to achieve normal function.
As a smart female student I learned that other students won’t like you and I learned to wait until no one else could answer a question before I raised my hand to be called on. {*PSA - teachers please don’t grade on a curve, or at least don’t publish the student’s scores if you do.} Currently, that strategy has not worked. For 2-3 years I’ve shared solutions that aren’t being picked up on by others. I need to start raising a megaphone instead of my hand.
Yes, this is bad, yes, taking nattokinase for a year may leave you feeling not well still - but take note - are you “suddenly dead” or are you still feeling unwell but not suddenly dead? The nattokinase may have helped you not be suddenly dead, but you likely need other specific health aids too because hyperinflammation and the chimeric spike and the modern diet are JUST THAT BAD!
Please share my work - make your own copies if you want. My name and my association with anything has been heavily suppressed by Cancel Culture since 2011/2012. I just think health is nicer than pain and like to share the good news that it is possible with some work and know-how. Going along with Cancel Culture is going along with the pedophile blackmail network, and why would you want to support their goals?
Disclaimer: This information is being shared for educational purposes within the guidelines of Fair Use and is not intended to provide individual health guidance.
Reference List, partial
(Broide, et al., 2019) Broide RS, Winzer-Serhan UH, Chen Y, Leslie FM. Distribution of α7 Nicotinic Acetylcholine Receptor Subunit mRNA in the Developing Mouse. Front Neuroanat. 2019 Aug 6;13:76. doi: 10.3389/fnana.2019.00076. PMID: 31447654; PMCID: PMC6691102. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691102/
(Rossman, 2011) Rossman AC. The physiology of the nicotinic acetylcholine receptor and its importance in the administration of anesthesia. AANA J. 2011 Oct;79(5):433-40. PMID: 23256274. https://pubmed.ncbi.nlm.nih.gov/23256274/
(Zheng, et al., 2021) Zheng W, Song H, Luo Z, Wu H, Chen L, Wang Y, Cui H, Zhang Y, Wang B, Li W, Liu Y, Zhang J, Chu Y, Luo F, Liu J. Acetylcholine ameliorates colitis by promoting IL-10 secretion of monocytic myeloid-derived suppressor cells through the nAChR/ERK pathway. Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):e2017762118. doi: 10.1073/pnas.2017762118. PMID: 33836585; PMCID: PMC7980392. https://www.pnas.org/doi/10.1073/pnas.2017762118
Hmmmm...I wonder if the nicotine lozenges would give me less nausea than the gum..... I would like to try again......
Good stuff Jenn!
Been taking lumbro alternating days with sera and natto for few weeks now and plan to for one year..and despite folk like awesome Dr Sasha and her scientist friend who she says found that natto didn't destroy spike and that there are more than one spike... she still says it has other health benefits..
So while we await hopefully more human trials , if these can help with atherosclerosis , why not give it a try..
Just wonder sometimes mixing coq10 and Nac and fish oil , resvetrol , nigella , Vit c and quercitin won't overdo the blood thinning a little much.. ;) so I alternate some of that too..
that's what I don't like about all this self medicating with natural products and their combining effect ..
Hope you feel better..
Yup It's all about inflammation and most have it in the west!