and what about Postbiotics? or Synbiotics? GOS, FOS, fructans, inulin or arabinoxylans? No worries, pomegranate peel can help. And gobo - burdock root.
A symphony orchestra in the gut? An estimated 70 - 90% of all immune cells in the body are located in the intestine, which thus houses more lymphoid tissue than all other lymphoid organs in our body combined - including the spleen and all lymph nodes!
.
WOW
💡However, this concentration of the immune system on the intestine also makes real sense, because the intestine is also a possible gateway for harmful organisms.
.
Therefore, their rapid detection and elimination directly on site is vital for us so that they cannot penetrate our organism.
.
🎼Many different cell types and tissues work together in the intestine for this immune response. As in a large orchestra, they combine their special skills so perfectly that a deadly symphony is created for harmful intruders:
.
✔The detection of harmful bacteria in the intestine is primarily carried out by sensors and specialized cells in the intestinal wall, especially in the vicinity of the so-called Peyer plaques. These plaques are special lymphoid tissues in the intestinal wall that are rich in immune cells (see clip).
.
✔Once harmful bacteria have been detected, the phagocytes (macrophages) are sent out to quickly engulf the identified bacteria. They then present fragments of the bacteria, so-called antigens, on their surface.
.
✔Dendritic cells recognize the presented antigens on the macrophages and take them up themselves. Then they dash to the nearby mesenteric lymph nodes, where they activate T and B lymphocytes.
.
✔Activated T lymphocytes stimulate further immune cells and additionally coordinate the release of signaling substances (cytokines) for targeted enhancement of the immune response.
.
✔Parallel stimulated B lymphocytes begin to produce specific antibodies against the harmful bacteria. These antibodies bind to the bacteria and mark them for final destruction.
.
✔Together, all these activated immune cells and antibodies manage to destroy the bacteria directly, or they call on other immune cells, such as neutrophils, to strengthen and finally destroy the invaders.
.
📣VERY IMPORTANT: As soon as the harmful bacteria are eliminated, the immune response is controlled and stopped to prevent an excessive permanent reaction. To do this, some of the T lymphocytes become regulatory T cells to dampen and shut down the immune response. If this does not happen, chronic inflammation can develop, usually accompanied by a change in the microbiome.
.
These are microorganisms that are our normal roommates in the intestine.
.
😍I have to admit, I'm always really speechless when I admire this perfect orchestra of immune cells that pursue only one goal: the preservation of our health.
JD - scorzonera - aka winter asparagus. The name derives from the Catalan word 'escorso' which means "viper". Known from ancient Greece as “barba di becco” or "beard of the peck (or beak bite)" in Italy because it was used as an antidote for snake bites.
Salsify (Tragopogon porrifolius) and black salsify (Scorzonera hispanica Family: Asteraceae) are different in more than color/ different species altogether per this, good article, https://www.spiceography.com/salsify/ , except that it is the black salsify that seems to have been used for snakebite.
"Due to the presence of numerous bioactive compounds, including flavonoid aglycones and glycosides, triterpenoids, sesquiterpenoids, quinic acid, and caffeic acid derivatives, in the studied plant material, Scorzonera species are considered a potential source of antioxidant agents. Although the reported cytotoxicity of Scorzonera extract against cancer cell lines so far was insignificant, they exhibit other bioactive properties, potentially applicable not only in the therapy of pain, inflammation, and microbial infections, but also as an enhancement of the effectiveness of the wound healing process." https://www.mdpi.com/1422-0067/22/10/5128 *comprehensive review article.
Sesquiterpenoids can be potent. Artemisinin from Sweet Wormwood, used for malaria, is a sesquiterpene lactone. (whatever that is ;-) I have found artemisinin or wormwood products helpful with CoV.
Nov 12, 2023·edited Nov 12, 2023Liked by Jennifer Depew, R.D.
JD - Terpenes can be classified according to the number of isoprene units in their structure (e.g., hemiterpenes are formed by one isoprene unit, monoterpenes are formed by two isoprene units, sesquiterpenes by three isoprene units, and diterpene formed by four units). Sesquiterpene lactones are a class of sesquiterpenoids built from three isoprene units that contain a lactone ring. Arty contains an unusual peroxide bridge. Terpenes are your friend.
Wow! Great research. Thanks so much, very informative. I bought some Urathin A, and I take Ellagic acid tannin. I have Long Covid fatigue and headaches. Need to take long tests during the day. What about honokio, Magnolia root?
I use Lion's Mane powder almost daily. It is good as a soup/sauce base. Bit of a miso soup effect. I am not familiar with magnolia root benefits.
There are many things that can help but you may need to work on changing your schedule. Slowing down or having a rest break more often really does become a need as autoimmune type symptoms are present / hyperinflammation. Like standing/busy 30 minutes, sit 15, up 30, sit 15 or something like that. I find I can get more leaf raking or other yard work down that is strenuous if I do one batch and rest, then another batch, and rest, repeat. Instead of overdoing it and crashing to rest for a bit with a racing heart rate.
LINKEDIN
STEPHAN BARTH THE IMMUNE SYSTEM
https://www.linkedin.com/posts/dr-stephan-barth_gesundheit-activity-7110850203355607040-4a3w
A symphony orchestra in the gut? An estimated 70 - 90% of all immune cells in the body are located in the intestine, which thus houses more lymphoid tissue than all other lymphoid organs in our body combined - including the spleen and all lymph nodes!
.
WOW
💡However, this concentration of the immune system on the intestine also makes real sense, because the intestine is also a possible gateway for harmful organisms.
.
Therefore, their rapid detection and elimination directly on site is vital for us so that they cannot penetrate our organism.
.
🎼Many different cell types and tissues work together in the intestine for this immune response. As in a large orchestra, they combine their special skills so perfectly that a deadly symphony is created for harmful intruders:
.
✔The detection of harmful bacteria in the intestine is primarily carried out by sensors and specialized cells in the intestinal wall, especially in the vicinity of the so-called Peyer plaques. These plaques are special lymphoid tissues in the intestinal wall that are rich in immune cells (see clip).
.
✔Once harmful bacteria have been detected, the phagocytes (macrophages) are sent out to quickly engulf the identified bacteria. They then present fragments of the bacteria, so-called antigens, on their surface.
.
✔Dendritic cells recognize the presented antigens on the macrophages and take them up themselves. Then they dash to the nearby mesenteric lymph nodes, where they activate T and B lymphocytes.
.
✔Activated T lymphocytes stimulate further immune cells and additionally coordinate the release of signaling substances (cytokines) for targeted enhancement of the immune response.
.
✔Parallel stimulated B lymphocytes begin to produce specific antibodies against the harmful bacteria. These antibodies bind to the bacteria and mark them for final destruction.
.
✔Together, all these activated immune cells and antibodies manage to destroy the bacteria directly, or they call on other immune cells, such as neutrophils, to strengthen and finally destroy the invaders.
.
📣VERY IMPORTANT: As soon as the harmful bacteria are eliminated, the immune response is controlled and stopped to prevent an excessive permanent reaction. To do this, some of the T lymphocytes become regulatory T cells to dampen and shut down the immune response. If this does not happen, chronic inflammation can develop, usually accompanied by a change in the microbiome.
.
These are microorganisms that are our normal roommates in the intestine.
.
😍I have to admit, I'm always really speechless when I admire this perfect orchestra of immune cells that pursue only one goal: the preservation of our health.
Video Credits: (Nature Videos)I
Thanks for sharing! that was a nice summary article.
You are the 1st RD I know that actually knows the real deal.
Reminds me of George Mateljan (rip). He used to catalog Foods affect on peeps from 'Nutritional Studies"
https://www.thriftbooks.com/w/the-worlds-healthiest-foods-essential-guide-for-the-healthiest-way-of-eating_george-mateljan/275466/
Thank you.
JD - scorzonera - aka winter asparagus. The name derives from the Catalan word 'escorso' which means "viper". Known from ancient Greece as “barba di becco” or "beard of the peck (or beak bite)" in Italy because it was used as an antidote for snake bites.
Salsify (Tragopogon porrifolius) and black salsify (Scorzonera hispanica Family: Asteraceae) are different in more than color/ different species altogether per this, good article, https://www.spiceography.com/salsify/ , except that it is the black salsify that seems to have been used for snakebite.
"Due to the presence of numerous bioactive compounds, including flavonoid aglycones and glycosides, triterpenoids, sesquiterpenoids, quinic acid, and caffeic acid derivatives, in the studied plant material, Scorzonera species are considered a potential source of antioxidant agents. Although the reported cytotoxicity of Scorzonera extract against cancer cell lines so far was insignificant, they exhibit other bioactive properties, potentially applicable not only in the therapy of pain, inflammation, and microbial infections, but also as an enhancement of the effectiveness of the wound healing process." https://www.mdpi.com/1422-0067/22/10/5128 *comprehensive review article.
Sesquiterpenoids can be potent. Artemisinin from Sweet Wormwood, used for malaria, is a sesquiterpene lactone. (whatever that is ;-) I have found artemisinin or wormwood products helpful with CoV.
JD - Terpenes can be classified according to the number of isoprene units in their structure (e.g., hemiterpenes are formed by one isoprene unit, monoterpenes are formed by two isoprene units, sesquiterpenes by three isoprene units, and diterpene formed by four units). Sesquiterpene lactones are a class of sesquiterpenoids built from three isoprene units that contain a lactone ring. Arty contains an unusual peroxide bridge. Terpenes are your friend.
Yes, I am having some Sweet Wormwood extract this morning in my hot not-coffee beverage. (I can't handle coffee anymore, sadly.)
This graphic set from an essential oil company is kind of helpful and includes sesquiterpenoids as a group. https://www.dropbox.com/scl/fi/uby3l1qqd8dvy65ro5v85/doterra-oil-chemistry-wheel-2019.pdf?rlkey=br5nc8l6dyxgzwxowhrnkyb7l&dl=0 The graphics are from this ebook on the chemistry of essential oils. Ginger has a sesquiterpenoid too and Ylang Ylang is a favorite scent of mine. https://www.dropbox.com/scl/fi/6spigdclt1mz6b1e5606w/doterra-essential-oil-chemistry-handbook.pdf?rlkey=wh1dl1wvt50gsieze6aeuc241&dl=0
That is interesting. thanks
This was very informative. Thank you.
Thank you Jennifer I saw this and thought you might like it I think this is fulvic acid/Shilajit which I’ve just started to take.
.
ION*Biome gut communication
Dr Zach Bush
https://www.theclaycure.co.uk/shop-claycure/ion-gut-ion-support/
DR ERIC BERG FULVIC ACID
https://youtu.be/3myDiaxX4Ts
Wow! Great research. Thanks so much, very informative. I bought some Urathin A, and I take Ellagic acid tannin. I have Long Covid fatigue and headaches. Need to take long tests during the day. What about honokio, Magnolia root?
I use Lion's Mane powder almost daily. It is good as a soup/sauce base. Bit of a miso soup effect. I am not familiar with magnolia root benefits.
There are many things that can help but you may need to work on changing your schedule. Slowing down or having a rest break more often really does become a need as autoimmune type symptoms are present / hyperinflammation. Like standing/busy 30 minutes, sit 15, up 30, sit 15 or something like that. I find I can get more leaf raking or other yard work down that is strenuous if I do one batch and rest, then another batch, and rest, repeat. Instead of overdoing it and crashing to rest for a bit with a racing heart rate.