Vitamins - a psy op akin to Virus isolation?; and 'inert ingredients' may be bioactive.
Caution is needed with fortified foods and supplements as the grand total can add up to too much of some synthetic or fat soluble vitamins. But "isolation" of a vitamin is not really similar to virus
I was asked about a post by Agent131711, who I have written a previous post about already. His writing style is inflammatory - rage or fear inducing and while there may be some facts, there is a lot of speculation or unfamiliarity with the topic too.
The post I was asked about is quoted and linked below. An excess of fat-soluble vitamin D or active retinoids (vitamin A) can add up to a health risk with long-term use.
The quick summary answer - do be cautious of fortified food bars or drinks for frequent snacks as the synthetic vitamins and minerals might be adding up to too much, especially if a multi supplement is also being used. If you eat a ‘meal bar’ with 100% fortification of some nutrients, and have three of them a day, then you just got 300% of some nutrients.
My answer (with an addition):
He's not really wrong exactly, but it is imagining the worse, or not seeing the point in having an 'isolate' molecule to be able to fortify foods with or put in a capsule.
Personally, I have a genetic need for high dose B6 which I would be unable to get from food. My high dose zinc need would be difficult without eating shellfish type of excellent sources. (Background: *I waste zinc and B6 by excreting kryptopyrroles instead of breaking them down further and recycling the vitamins. This is known as pyroluria and it can be a genetic condition or acquired I read recently. It is not screened for or treated by the mainstream medical industry even though it can be a common problem in conditions with congenital gene differences such as Down’s Syndrome or ADHD.)
Random fortification of foods with vitamin D was a concern of mine which I wrote about a lot starting late 2010 - wrote about it enough to get Cancel Culture set on me. It was a win kind of I thought, the whole topic of vitamin D got so ugly that it was no longer trendy to food fad it onto your Waffle box or Toaster Pastry box label.
"Shockingly, we discovered the child was exceeding the United Nations / FDAs daily intake levels of vitamins. In fact, the child who is living off processed food is dangerously high in his intake of synthetic fat soluble vitamins, such as Vitamin D, in which each dose is stored in our body fat for years, easily leading to toxic levels that disguise themselves as other health conditions (anxiety, stomach pain, weakness, dizziness, bone problems, kidney issues, heart problems, seizures and more)." - From Agent131711's post.
He gets heavily into comparing vitamin/chemical isolation with virus isolation and the two topics are not at all related and size wise, not on the same microscopic level of size. Riboflavin, vitamin B2 has a molecular weight of 376.4 g/mol. (3) Riboflavin detail, just as an example of the chemistry considered in isolating or synthesizing a vitamin - and the breakdown considerations ~ how to store it for more shelf stability. (4)
For comparison while viruses or alleged viruses vary in size - they are much larger, a membrane droplet of molecules clustered together adds up to as large as 2.6 million riboflavin equivalents or a smaller 265 riboflavin equivalents.
"The molecular weight of viruses can range from around 10^5 daltons (100,000 g/mol) to 10^9 daltons (1,000,000,000 g/mol), depending on the virus family, genome size, and composition." (1)
Background info: one Dalton equals 1 gr/mole :: 1 Da = 1 g/mol (2)
Summary of supplements to Avoid-at-all, or to avoid in excess:
Avoid: Cyanocobalamin (B12 linked to cyanide instead of a methyl or hydroxy group. Look for “methyl-cobalamin” or “hydroxy-cobalamin” on the label.
Avoid: Folic acid - methyl folate is the active form, an excess of folic acid may be inflammatory due to it competing for bioactive folate or by adding too much uric acid from purine production and breakdown into a waste chemical.
An excessive use of methyl folate or folic acid is also a bad idea because it acts as a negative feedback loop in the methylation cycles. Too much folate tells the body to slow down on remethylating folate, which then means all of the interconnected methylation cycles may be slowed down too. 400 micrograms per day of methyl folate is the typical recommendation and more is not needed, or as a water-soluble nutrient, take smaller divided doses throughout the day.
Avoid: Fluoride - it is a myth that the teeth or the body needs fluoride for health.
N-acetyl cysteine (NAC) has gotten really popular since CoV era as a supplement, but it also deserves caution as a negative feedback control on the methylation cycles. The body sees too much cysteine and it slows down a step in the interconnected methylation cycles, which then may slow them all down. It is an amino acid which is not uncommon in protein rich animal or plant foods. Most people get enough cysteine in their diet unless they are really not getting enough total protein. The recommended limit is ~ 600 mg per day in normal health as a preventative (it supports glutathione production) and ramp that up to more frequent doses during an infection or inflammatory condition.
Vitamin D - fat soluble and an excess can lead to hypercalcemia in susceptible people (*sarcoidosis, parathyroid cancer and a few infectious conditions) or anyone if the active form of D3 is being used.
Vitamin A in active retinoid forms - supplements, medications, and facial creams may add up to a toxicity along with a liking for liver, a food source of active vitamin A.
Vitamin C is water-soluble (lost in urine daily), so it is less of a risk to health than fat soluble vitamins. However, anyone with a tendency towards uric acid excess and gout symptoms, or who tends to be over acidic within the body, may be at risk from higher dose vitamin C. Limiting intake to 100-250 mg per day, and in smaller divided doses, may be a sensible precaution for preventive self-care. When the body is fighting an infection or inflammatory condition, then larger doses spaced throughout the day may help but the body just dumps an excess as diarrhea, so there is no point in taking way too much at once. Liposomal vitamin C is better absorbed for that need or IV thiamine and vitamin C is given by functional health providers for sepsis type conditions (Marek Protocol).
Iron is a trace nutrient metal/mineral which can add up to an excess in post-menopausal women and biological males when fortified breakfast cereals or meal replacement drink mixes or foods are used regularly.
Manganese is a trace nutrient metal/mineral which has a narrow range of safety. Someone using a lot of fortified products and supplements might add up to an excess intake. Iodine, selenium, and chromium can add up also, but are less frequently added to mixed supplements in large amounts. Pure maple syrup is a natural source of a generous amount of manganese - 1/4 to 1/2 cup per day is the sensible limit for manganese intake.
»> There are probably others - do feel free to add any nutrient concerns in the comments.
Specific ‘synthetic’ nutrients that might be harmful - cyanocobalamin contains cyanide and long-term use has led to cyanide poisoning. Folic acid is added to stuff and talked about as if it is the same thing as folate but it is not. An excess may be adding to health risks for a wide range of people and would not be helping anyone with difficulties remethylating folate in the methylation cycles. Riboflavin, vitamin B2, taken in larger amounts, (100 mg twice or four times a day), might help more with a common MTHFR gene allele that causes the B2 cofactor to disconnect. If migraines are a frequent problem, consider trying the B2 idea as it is nontoxic, water soluble, and easy to see in your urine as a bright yellow highlighter marker color.
Inert Ingredients are another can of worms, to avoid eating:
Things to avoid in supplements can also include the ‘inert ingredients’.
Avoid: Titanium dioxide is added as a whitener, but it is a heavy metal nanoparticle that has no place in food or medications or cosmetics, yet it is there.
ALWAYS read the fine print, these days. The food and medication and supplement industries are out to make money and the government “oversite” is not as helpful as we tend to expect or hope.
I try to avoid gelatin capsules, as gelatin may contain glyphosate.
Xanthum gum and other emulsifiers in food products may add to diarrhea or digestive symptoms. They may also be used in drink mixes or other supplement or formula products.
Food dyes used to add color to supplements or medications can be a cause of behavioral symptoms or headaches. I can’t use red and yellow dyes which means green, brown and purple are also a problem, but blue is okay. *This has to do with my gene alleles, one or more of which* make it difficult for me to breakdown phenols/polyphenols, catechol and benzene ring chemicals - this includes my salicylate sensitivity. Phenols have a benzene ring attached to an alcohol group, and flavonoids/flavonols are in this group. Sadly, this includes coffee. Catechols for me to avoid as higher dose supplements (more so than avoiding all food sources) include quercetin, fisetin, luteolin, rutin, oleacin (olive oil), EGCG (green tea and pomegranate peel/products). **These phytonutrients in supplement doses may help improve dopamine levels for patients with Parkinson’s disease.
*COMT - Val158Met, AA is the ‘slow’ activity leaving higher levels of dopamine and other catechol chemicals left to accumulate. Estrogen dominance may also be more of a risk with low COMT activity - supplementing with Wild Yam progesterone cream topically has helped me to be less cranky during peri and post menopause. GG is ‘fast’ activity which leaves low dopamine levels and breakdown of catechols or morphine medications would be faster than typical. The low activity folks may be more perfectionistic and have better memories but are at more risk for schizophrenia and bipolar disorder too.
Low activity - higher dose methyl-B12 or SAMe might add to elevated dopamine and norepinephrine symptoms. Instead consider supporting the transulfuration, methionine/homocysteine, and Krebs/Citric acid cycle pathways in general to promote all of the interconnected pathways to chug along at a good pace. Good gut health also helps support methylation cycle function.
“For most drug products, the major components by mass are not the active pharmaceutical ingredient (API) but rather are excipients; these are classified as “inactive ingredients” in the FDA’s Inactive Ingredients Database (IID; www.fda.gov/Drugs/InformationOnDrugs/ucm113978.htm). Examples of excipients are molecules such as lactose, pectin, and xanthan gum, which stabilize the API in pill form; antioxidants such as propyl gallate that improve shelf life; detergents such as sodium lauryl sulfate that solubilize the API in the gut; and dyes such as FD&C Yellow No. 5 (tartrazine), D&C Red No. 28 (Phloxine B), and FD&C Blue No. 1 (Brilliant Blue FCF) that color medicines so that they can be better distinguished by patients and pharmacists. In many drug formulations, excipients can reach concentrations of hundreds of micromolar to millimolar in the gastrointestinal tract, up to 100 times the concentration achieved by the API.” (Pottel, et al., 2020)
This research team did a computer-based analysis of chemicals commonly used as ‘inert ingredients’ also known as excipients and the team found quite a few to be biologically active and potentially harmful at current dosing levels. Nineteen were found to negatively affect activity of the COMT enzyme.
“Nineteen excipients were found to be active against at least one of 12 targets, including muscarinic acetylcholine receptors, the intestinal organic anion transporter 2B1 (OATP2B1), and catechol O-methyltransferase (COMT),…” (Pottel, et al., 2020)
See Tables 1 and 2 for details of the ‘inactive’ chemicals and the gene targets at which the chemicals were identified as being potentially bioactive - inhibition of receptors with a few agonists/activators:
“From the two approaches, 38 “inactive ingredients” emerged with 134 activities against 44 targets (Tables 1 and 2 and tables S1 to S3).” (Pottel, et al., 2020)
And (Table 3) provides details about chemicals which were then also screened in a cell culture test for further information. That Table informs us that Thimerosal and Cetyl pyridinium chloride caused acute toxicity at > 3.3 microMole, and D & C Red #28 caused acute toxicity at > 30 microMole. Cetyl pyridinium chloride was a microtubule disruptor at 1.1 microMole. Propyl gallate and Butyl paraben caused organ toxicity level damage at greater than 3.3 microMole levels and immunosuppression at greater than 10 microMole. (Table 3, Pottel, et al., 2020) *This paper and its Tables provide a ton of valuable information about potential effects of ‘inert ingredients’, however it would take more familiarity with the genes than I have to understand the implications at a glance. I would need to spend more time looking up all the gene/enzymes to understand whether the inhibition or activation is potentially harmful, helpful, or benign.
In the case of pesticides, and evaluation of the safety of agricultural mixtures - the effect of ‘inert ingredients’ is not even evaluated — and it has been shown to make a big difference in the toxicity of Round-up products. The inert ingredients help get the glyphosate across thin skin of mucous membranes and is a big risk to amphibians and fish in aquatic wild spaces.
“The findings of Richard et al. (2005) are an important addition to our understanding that the health and environmental effects of formulated pesticide products are not fully reflected in tests conducted on the active ingredient(s) alone. It has been long known that the adjuvants (commonly and misleadingly called “inert” ingredients) may be toxic and may enhance or supplement the toxic effects of the active pesticidal ingredient.
In the case of glyphosate-containing products, this phenomenon was well demonstrated in the data submitted to the (EPA) by the registrant (Monsanto), and summarized by the U.S. EPA in the Reregistration Eligibility Document (RED) for glyphosate (U.S. EPA 1993). For example, based on the registrant’s own tests of acute toxicity to freshwater fish, the U.S. EPA classified technical grade glyphosate as “slightly toxic” to “practically non-toxic” and formulated products ranged from “moderately toxic” to “practically non-toxic.” Tested alone, the surfactant adjuvant (identified as “inert”) was “highly toxic” to “slightly toxic.” Similar differences were reported in tests of acute toxicity to freshwater invertebrates.
Based in part on the data in the glyphosate RED (U.S. EPA 1993), the New York State Attorney General’s office successfully pursued an action against Monsanto in 1996 (Attorney General of the State of New York 1996). At that time, Monsanto was making advertising claims about the toxicity of the Roundup products based on data from tests on the active ingredient alone. Such claims are scientifically unfounded and inherently deceptive. The Attorney General’s action was facilitated by the availability of at least some limited information about the inert ingredients and their toxicity. That same sort of information enabled Richard et al. (2005) to conduct their study.
Unfortunately, that is not always the case, and for many pesticide products, little or no information about the identity of inert ingredients is publicly available. Registrants are generally required to conduct acute toxicity tests on formulated products, but they traditionally conduct chronic toxicity tests on the active ingredient alone. Even when formulated products are tested, the identity of inert ingredients is rarely revealed in the open literature, publicly available regulatory documents, or product labels. Therefore, independent research is stymied, and the public is ill-informed in the marketplace.” (Reproduced with permission from Environmental Health Perspectives, Surgan, 2005) *That is the entire statement, click through for a short reference list.
Inert ingredients may not even be listed on a pesticide label as it may be considered ‘proprietary information’. Some websites exist where additional information can be looked up.
Additional Resources [*for looking up inert ingredients contained in pesticide products]:
Inert Finder - US Environmental Protection Agency (EPA)
PR Notice 97-6: Use of Term "Inert" in the Label Ingredient Statement - EPA
Inert Ingredients Permitted for Use in Nonfood Use Pesticide Products - EPA
Inert Ingredients Approved for Use in Minimum Risk Pesticide Products - EPA
On a related note - a “poem” by Toby Rogers:
“Fillers: toxic asf
Breast implants: toxic asf
Botox: absurd
Mammograms: cause cancer
IUDs: barbaric
ADHD meds: legal meth
Sex change surgeries and puberty blockers for kids: psychotic
Obstetrics: toxic asf
Circumcision: madness
Statins: total junk science
SSRIs: total junk science
CDC vaccine schedules: genocidal junk science
Covid response: genocidal junk science
Hospitals: very expensive kill zones
Oncology: very expensive kill zones
Opioids: slavery [and if you are diabetic, and/or low in magnesium, opioids don’t even work as pain killers unless magnesium is provided. Magnesium alone worked better as a pain killer.]
Health insurance: organized crime
Public health: organized crime
AAP, AMA, ACOG, NEJM: organized crime
WHO, NIH, FDA, & CDC: genocidal fascism
BMGF, Rockefeller Foundation, Wellcome Trust: genocidal fascism.
Western allopathic medicine, wtf are you doing!?
You could not design a more anti-human, anti-health system if you tried.”
— Toby Rogers. (Substack Notes)
Disclaimer: This information is being shared for educational purposes within the guidelines of Fair Use and is not intended to provide individual health care guidance.
Reference List
Other/Inert Ingredients in Pesticides, National Pesticide Information Center, http://npic.orst.edu/ingred/inert.html
Pottel, J., Armstrong, D., Zou, L., et al., The activities of drug inactive ingredients on biological targets. Science 369,403-413(2020). DOI:10.1126/science.aaz9906 https://www.science.org/doi/10.1126/science.aaz9906 (Pottel, et al., 2020)
Surgan MH. Toxicity tests: "inert" and active ingredients. Environ Health Perspect. 2005 Oct;113(10):A657-8; author reply A658. doi: 10.1289/ehp.113-a657c. PMID: 16203224; PMCID: PMC1281320. (Surgan, 2005) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1281320/
Completely agree with your assessment of the Agent feller. Total fear monger. No thank you!
You’re much appreciated Jennifer. 🙏💖 Just the facts ma’am. 😁
Thank you heaps Jennifer -:))