It could help. Maybe taje it earlier in the day though rather than bedtime.
It might stimulate.
It is precursor to serotonin which is activating daytime rather than being highest at night. Bakance between multiple things is how sleep and wake work.
JD - Your welcome and thanks for the hat tip. "It inhibits reuptake, so whatever level of serotonin is present would be used longer" Indeed, and when combined with SSRI, SNRI, MAOI or TCA (all of which are contraindicated) can lead to excess serotonin levels aka SEROTONIN SYNDROME which can be mild to severe, and potentially fatal. https://en.wikipedia.org/wiki/Serotonin_syndrome
Yes, you're welcome and thanks, I should have copied the Caution from the last post into this one too. And there was a question about asthma - I should clarify the potential 'inhibitor' question. St. John's Wort is an activator rather than inhibitor. The 'avoid dietary arachidonic acid' tip would be pertinent for conditions with overactive TRPC6 channels. Trials with TRP channel inhibitors generally go poorly because the channels do such varied and important functions.
After my recent troubles with salicylate excess - that can be a cause of asthma - just get the salicylates reduced enough and the asthma just stops.
An overly acidic body can make excreting salicylates not work, so it can be a side effect of chronic inflammation to also become salicylate sensitive and it is everywhere in so many foods, and mint products.
It is hard to avoid and could cause symptoms indefinitely - as long as the diet/products have salicylates, the asthma could continue - but there would probably be other symptoms too. Not only asthma.
Avoiding the TRP channels that set off my colitis/bowel symptoms was my strategy when that was severe/new onset and confusing until I learned about TRP channels.
not St John’s Wort, no. I would need to do another follow up on what might help overexpression.
Avoiding arachidonic acid - brothy chicken bone stock - might help. In the cystic fibrosis section.
limit the inflammatory triggers rather than looking for a TRPC6 inhibitor. Generally inhibiting TRP channels is a really bad idea, with bad results, because they do so many important things throughout the body - and often varied things, for the same channel type.
Jennifer, what about 5-HTP or L-Tryptophan ?
It could help. Maybe taje it earlier in the day though rather than bedtime.
It might stimulate.
It is precursor to serotonin which is activating daytime rather than being highest at night. Bakance between multiple things is how sleep and wake work.
JD - Your welcome and thanks for the hat tip. "It inhibits reuptake, so whatever level of serotonin is present would be used longer" Indeed, and when combined with SSRI, SNRI, MAOI or TCA (all of which are contraindicated) can lead to excess serotonin levels aka SEROTONIN SYNDROME which can be mild to severe, and potentially fatal. https://en.wikipedia.org/wiki/Serotonin_syndrome
Yes, you're welcome and thanks, I should have copied the Caution from the last post into this one too. And there was a question about asthma - I should clarify the potential 'inhibitor' question. St. John's Wort is an activator rather than inhibitor. The 'avoid dietary arachidonic acid' tip would be pertinent for conditions with overactive TRPC6 channels. Trials with TRP channel inhibitors generally go poorly because the channels do such varied and important functions.
So since TRPC6 channels are over-expressed in several chronic illnesses, including asthma, do you think it would help this condition?
After my recent troubles with salicylate excess - that can be a cause of asthma - just get the salicylates reduced enough and the asthma just stops.
An overly acidic body can make excreting salicylates not work, so it can be a side effect of chronic inflammation to also become salicylate sensitive and it is everywhere in so many foods, and mint products.
It is hard to avoid and could cause symptoms indefinitely - as long as the diet/products have salicylates, the asthma could continue - but there would probably be other symptoms too. Not only asthma.
Avoiding the TRP channels that set off my colitis/bowel symptoms was my strategy when that was severe/new onset and confusing until I learned about TRP channels.
I get a thrill from solving a puzzle:
‘And what do osmomechanical stress, changes of temperature, chili powder, curry powder, ginger, Benicar, hormone D, steroids, and cannabinoids have in common?’ https://open.substack.com/pub/denutrients/p/osmomechanical-stress-temperature-chili-curry-ginger-benicar-d-steroids-cannabinoids?r=os7nw&utm_campaign=post&utm_medium=web
solving that puzzle also led to stabilizing the colitis.
not St John’s Wort, no. I would need to do another follow up on what might help overexpression.
Avoiding arachidonic acid - brothy chicken bone stock - might help. In the cystic fibrosis section.
limit the inflammatory triggers rather than looking for a TRPC6 inhibitor. Generally inhibiting TRP channels is a really bad idea, with bad results, because they do so many important things throughout the body - and often varied things, for the same channel type.