Russell Blaylock, Excitotoxicity author, glutamate negative impact on hippocampus
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Russell Blaylock broke ground in the field of glutamate overactivity and it's negative impacts on hippocampus cells of the brain. They are rich in NMDA receptors which is activated by glutamate or aspartate. Excitotoxins causing Excitotoxicity was the descriptive term in his book of similar title.
Calcium is allowed to rush into the cell, and now we know from Cells, Gels, and the Engines of Life by Gerald H. Pollack, that will lead to condensing of intracellular proteins and reducing structured water zones - and water might leak out somewhere. Increased intracellular calcium also causes endocannabinoid release from the cell membrane which is anti-inflammatory initially and then breakdown products have inflammatory signaling. Calcium increase inside the cell also can cause overactivity in general of the cell, which can lead to cell death from excess metabolic waste build up, like lactic acid and other ROS chemicals.
Screenshots from the lecture tonight:
The screenshots are from the webinar that was held tonight, mentioned in the post below:
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Chat links from the Russell Blaylock lecture - IPAK-EDU notes
The Blaylock Health Channel: https://www.youtube.com/user/blaylockhealthchl/videos
Channel: Russell Blaylock M.D https://www.youtube.com/channel/UCPvDn8vvYN6rk890faj8RMg/videos
Quinolinic acid, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/quinolinic-acid
“Quinolinic acid is a neuroexcitotoxic metabolite of L-tryptophan and an agonist of N-methyl-d-aspartate receptors. Increased levels have been found in people with a variety of neurological diseases including AIDS (Heyes et al., 1992) and macaques infected with simian immunodeficiency virus (Smith, 1995). Quinolinic acid levels may be elevated in the CSF of animals with inflammatory nervous system disease. Therefore, they may be useful as a marker of inflammation and perhaps also as an indicator of prognosis (Smith, 1995).”
Cerebrospinal Fluid, William Vernau, ... Cleta Sue Bailey, in Clinical Biochemistry of Domestic Animals (Sixth Edition), 2008, Viewable at: Quinolinic acid, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/quinolinic-acid
‘Glyphosate and many other toxins are implicated via ER stress - see my opus "Autism is an Acquired Cellular Detoxification Deficiency Syndrome"‘ - James Lyons-Weiler https://www.longdom.org/open-access/autism-is-an-acquired-cellular-detoxification-deficiency-syndrome-with-heterogeneous-genetic-predisposition-2165-7890-1000224.pdf
Luteolin would be protective against excitoxicity per Russell Blaylock. Anti-senescents would also likely help. See quote below.
Curcumin or quercetin in a nano-formulation as they aren’t absorbed in the bioactive form otherwise was a recommendation. Thorne brand is one he trusts for supplements but there was another company I forget the name - it might be this company, with vegetable capsules as a plus. (oneplanetnutrition), otherwise not inexpensive and fairly small doses.
Russell Blaylock mentioned that gelatin is high in glutamate and is being used in a lot of supplement products but better to get the vegetable [cellulose] capsules. Glyphosate can also be in commercially raised animal products. Omega 3 fatty acids, diets high in fish, and vitamin D3 were mentioned as being protective.
Link I shared: "Naringenin, hesperetin, hesperidin, quercetin, fisetin, kaempferol, rutin, apigenin, luteolin, nobiletin, tangeretin, genistein, wogonin, epigallocatechin gallate (EGCG), theaflavin-3-gallate (TF2A), and procyanidin C1 possess potent antisenescence effects." https://link.springer.com/article/10.1007/s40290-022-00444-w
Addition, Food sources of luteolin: Luteolin is a flavonoid "found in celery, thyme, green peppers, and chamomile tea," (18) and "chrysanthemum flowers, sweet bell [green/red/orange] peppers, carrots, onion leaves, broccoli, and parsley [7 8]. (21) Reference in Ground Ivy… post which has food sources for a few other phytonutrients too.
See page Phytonutrients on jenniferdepew.com for more food sources of some of the phytonutrients mentioned in the earlier antisenescence quote.
Link shared by another attendee regarding the anti-inflammatory benefits of cardamom spice: Neuroprotective Effect of Cardamom Oil Against Aluminum Induced Neurotoxicity in Rats, https://www.frontiersin.org/articles/10.3389/fneur.2019.00399/full
Disclaimer: This information is being provided for educational purposes within the guidelines of Fair Use and is not intended to provide individual health guidance.
Strontium, an mineral sold OTC as a nutritional supplement, appears to be beneficial in excitotoxicity. I
believe that it could be added to the list of recommendations for mitochondria health.
Strontium (Sr) can replace calcium (Ca) in cell signaling. However, Sr tends to be less active than Ca. So, it tends to reduce excess Ca activity.
Sr slows excess Ca influxes into the mitochondria and Sr also reduces ER stress. Sr has been shown to prevent apoptosis, reduce mitochondria swelling from toxins, reduce mitochondria swelling in rats subjected to extreme exercise, and reduce mitochondria and liver damage from in 6 patients admitted to the emergency room from excess alcohol intake.
Sr also replaces Ca in nerve cells and modifies synapses, limits neurotransmitter release and reduces the pain message sent to the brain. It also reduces the "danger" messages sent to other cells (from the TLRs and other mechanisms.) Sr reduces neuroinflammation, cytokine storms, and negative sensations such as pain and itch. In 1924, Dr Alwens found that he could eliminate the need for morphine with a few weeks of Sr injections. His successes include bone diseases, Parkinson's, phantom limb pain, various inflammatory diseases, and much more. A recent study shows that Sr prevents brain damage associated with NAFLD in mice.
Sr has also been shown to prevent sepsis, help diabetes, reverse cachexia and a lots more.
Sr is very safe, and has been used in medicine since the mid 1800s.
Some of my research has been posted on my Substack page. My email address can be found on my articles if anybody has questions.
https://joeanstett.substack.com/p/benefits-of-strontium
https://joeanstett.substack.com/p/your-nerves-on-strontium-part-1
https://joeanstett.substack.com/p/your-nerves-on-strontium-part-3-a
Thank you for this post! Filled with useful information.
I wonder if anyone could comment on NAC as a prophylactic for Glutamate toxicity?