It can affect Vitamin D and Thyroid receptors, transcribe proteins, and affect fetal development. ADHD may have alcoholic sperm as an underlying causal factor.
Thanks! Maybe it led to excess histamine and then folate deficiency after it was used to break down the histamine - I don't know if that is how the chemistry would work though. I will have a look.
PVN - the second reference #132 - PVN of the hypothalamus is very involved in circadian cycle controls. https://pubmed.ncbi.nlm.nih.gov/34599158/ When the circadian cycle is disrupted then the Nrf2/night-time pathways are inhibited, and the activity oriented daytime NF-kB pathways are active - and increasing oxidative stress and continuing to inhibit Nrf2.
Thanks again, several very interesting articles! The folate might have to do with histamine. I notice worse symptoms if I forget my folate supplement too often. I do have methylation gene differences.
nice work, thanks.
Ran across a folate-deficiency paper from 2008 a few years ago.
Decreased plasma folate concentration in young and elderly healthy subjects after a short-term supplementation with isotretinoin.
A couple other related papers and comments at
https://ggenereux.blog/discussion/topic/pubmed-research-papers/?part=14
part way down the page at #135 · October 4, 2019, 10:19 am
Hope it might help in your valuable research.
Thanks! Maybe it led to excess histamine and then folate deficiency after it was used to break down the histamine - I don't know if that is how the chemistry would work though. I will have a look.
PVN - the second reference #132 - PVN of the hypothalamus is very involved in circadian cycle controls. https://pubmed.ncbi.nlm.nih.gov/34599158/ When the circadian cycle is disrupted then the Nrf2/night-time pathways are inhibited, and the activity oriented daytime NF-kB pathways are active - and increasing oxidative stress and continuing to inhibit Nrf2.
Thanks again, several very interesting articles! The folate might have to do with histamine. I notice worse symptoms if I forget my folate supplement too often. I do have methylation gene differences.