10 Comments
Oct 1, 2023Liked by Jennifer Depew, R.D.

Thanks for this information. We, in Australia, have one litre bottles

of organic Pomegranate Juice from Georgia in our supermarket.

It is tart but a great drink.

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I use an organic brand out of Georgia too. It seems to have more peel in it. I add a tiny dash of baking soda and a little sweetener to my mom's serving of it. 'Prime Juice' seems to be the brand and it is definitely medicinal with some diuretic power.

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Oct 1, 2023Liked by Jennifer Depew, R.D.

To bypass the buying of the incredibly delicious juice AND middle-man supplementation; pomegranate vinegar. Sweet, tart and naturally probiotic.

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Yes, and/or pomegranate wine. Post biotic urolithin A and B is a benefit of fermented pomegranate products.

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Oct 1, 2023Liked by Jennifer Depew, R.D.

Wine would be amazing. Hadn't thought of that.

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Oct 1, 2023·edited Oct 1, 2023Liked by Jennifer Depew, R.D.

Many Thanks for sharing this, Doc. Did you have any thoughts on the action of pomegranate (or any other interventions that come to your mind) on Advanced Glycation Endproducts (AGEs) that have been attributed to a range of pathologies including PCOS that this article touches upon. I found this to be useful in setting the context of understanding the role of AGEs. A lot has been said about insulin resistance but I reckon this is another area that warrants more attention and research especially given its contribution to chronic inflammation and related diseases.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600625/

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Weird that ice cream is a source of AGEs. Breakfast cereal and barbecue, sure, high heat processed, but ice cream?

OOO "Drinks with caramel additives such as Coke Classic or Diet Coke were found to contain 8500 and 9500 units/cup compared to 475 units per cup in Sprite, 600 in orange juice, and around 2000 in coffee and tea.20" I have some coconut 'sugar' that is very caramel flavor and brown. I had wondered how bad it might be in AGEs. I use it in fairly small amounts.

Regarding pomegranate - would likely help any inflammatory issues including AGE induced oxidative stress. Yes, on seeing Table 1 - pomegranate belongs there too, not just the juice alone though. Peel or flower extracts were effective against glycation risks. I found a citation specific enough to support that statement. However it seems to be more about preventing protein glycation within our bodies, rather than protecting against dietary sources - ut it should help both causes of inflammation.

Anti-glycation, antiplatelet and antioxidant effects of different pomegranate parts https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-022-03824-6

Interestingly, the pomegranate flowers proved to be most potent against AGEs

Abstract: "Platelet aggregation and advanced glycation end products (AGEs) and oxidative stress are known as key factors for the development of cardiovascular diseases and diabetic complications. In this context, fruit and vegetable consumption, good sources of antioxidant compounds have been largely reported as an effective way of preventing human against these diseases. The current study focuses on the evaluation of antioxidant, antiplatelet and anti-glycation activities of pomegranate (Punica granatum L.) flowers (PF), leaves (PL), peel (PP) juice (PJ) and seeds oil (PSO).

Methods

Antioxidant activities was measured against ABTS radical and lipid peroxidation. Antiglycation activity was determined using the formation of AGE fluorescence intensity in the BSA/ribose system. Antiplatelet activity was measured in platelet rich plasma (PRP) against adenosine diphosphate (ADP), Collagen and arachidonic acid (AA).

Results

PF extract displayed the highest antioxidant activity against ABTS and lipid peroxidation with IC50 values of 0.7 mg/mL and 0.63 mg/mL respectively. For anti-glycation activity, PP, PF and PL inhibited moderately the pentosidine-like AGEs formation compared to positive controls with AGE-IC50 value of 0.4 mg/mL. PJ and PSO haven’t any anti-AGE effect. All the extracts selectively inhibited platelet aggregation caused by one, two or three inducers in dose dependent manner. PF was the most potent inhibitor caused by all three inducers, with inhibitory effects ranging from 35.6 to 66.6%. PP and PJ exhibited antiplatelet effect against both ADP and collagen and PL and PSO only against AA.

Conclusions

These results suggest that some pomegranate extracts exert potential in vitro anti-glycative and antiplatelet activities."

Amri, Z., Amor, I.B., Zarrouk, A. et al. Anti-glycation, antiplatelet and antioxidant effects of different pomegranate parts. BMC Complement Med Ther 22, 339 (2022). https://doi.org/10.1186/s12906-022-03824-6 https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-022-03824-6

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Many Thanks for this, Doc. Thorough and insightful as always.

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"These findings strongly suggest that a synbiotic-infused, pomegranate beverage may improve the hormonal balance in patients with PCOS, while adding improved insulin resistance, staving off diabetes and improving BMI and body weight, while also improving the figure." - Thanks Jen. Does such a beverage exist? Peace.

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Thanks. I came across something stating PCOS can be a result of parasitic infection and with treatment has total recovery. Don't remember details, although from memory the name of specific parasite was given. As myself not sufferer (and don't know anyone who is) I only read out of curiosity.

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