New CVD research - omega 3 beneficial, beta-carotene not helpful, increased all-cause mortality risk.

Retinoid Toxicity is involved is my guess. Helpful - mitochondrial support, vit D, Mg, Zn; mitochondrial support - a-lipoic acid, CoQ10, melatonin; & catechin, flavanol, querctin, & curcumin.

The work by (Gormaz, Carrasco, 2022) Juan G. Gormaz, Rodrigo Carrasco, (2022). Antioxidant Supplementation in Cardiovascular Prevention∗: New Challenges in the Face of New Evidence, Journal of the American College of Cardiology, 80(24):2286-2288, ISSN 0735-1097, https://doi.org/10.1016/j.jacc.2022.10.011. https://www.sciencedirect.com/science/article/pii/S0735109722071236 , the article is not viewable to me and is discussed in an article on NutraIngredients: Meta-analysis: Some micronutrients may be better for the heart than others, (nutraingredients-usa.com).

The team list many things found helpful to some level of ‘evidence'-based criteria, while vitamin C, D, E, and selenium did not show long-term protective benefits for cardiovascular health. The beneficial list for moderate to high quality evidence for reducing risk factors for CVD is longer and includes vitamin D (sunshine or full spectrum light might be even better):

• omega-3 fatty acid with the strongest evidence, omega-6 fatty acid (probably GLA or CLA);

• the amino acids: L-arginine, L-citrulline;

• folic acid - also stronger evidence - (think what methyl folate could do);

• vitamin D, magnesium, zinc, (immune support);

• alpha-lipoic acid, Coenzyme Q-10, melatonin, (mitochondrial support);

• catechin, curcumin, flavanol, and quercetin; (pomegranate peel plus curcumin, onion, and moong dal curry - phytonutrient rich and protein).

And the interesting clincher - beta-carotene was a negative, increasing all-cause mortality. (nutraingredients-usa.com). Hmmm - Retinoid Toxicity is my guess.

Vitamin C may not be helpful consistently as it is a pro-oxidant and when too much is used it may increase inflammation more than is present. Higher doses are needed during the inflammatory situation, not as a prevention. I take 100 mg a day and upped that to several 100 mg a day while sick with CoV. Alpha-lipoic acid is an antioxidant that is less likely to act in any pro-oxidant way. I take 200 mg / day of CoQ10 and have been using 10-20 mg melatonin several times during the day with high dose niacin. I use Epsom salt baths for magnesium and 1000-2000 units of vit D but prefer the sun. I use a higher than RDA for each of the Bs and methyl forms of folate and B12. A good Trace Mineral mix is in my supplement routine, plus selenium and extra zinc.

Salmon, and beta-carotene rich vegetables. I would eat the cucumbers and peas and broccoli which has some beta-carotene but not as much as the carrots, squash and tomatoes. Photo by Sam Moghadam Khamseh on Unsplash

Health can be delicious, and trickier than we may realize.

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.