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Mehen's avatar

Hi Jennifer, I have an OT question: what would you recommend (besides quitting drinking) for someone with alcoholic hepatitis/early cirrhosis?

Or alternately, what to avoid?

TIA

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Jennifer Depew, R.D.'s avatar

Without looking it up - avoid in addition to alcohol, fruit sugar, over-eating in general, and inflammation in general.

and Milk Thistle might help. Pomegranate products are healing throughout the body.

search results for cirrhosis diet - suggests extra calories and protein are needed, but spread it out over the day and evening (rather than an intermittent fasting style). https://pubmed.ncbi.nlm.nih.gov/29912757/

High protein goal: 1.2 grams protein per kilogram usual or ideal body weight.

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Michael Edwards's avatar

Holy wow!!! That first offset, purple lined, paragraph that starts off: ... Knockdown of Nrf2 by siRNA... is a real doozy!!! I have degrees in biology, chemistry and studied and worked all my life in medicine, industrial hygiene and environmental science and I have no idea what that means!!! Lol 😂!!!

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DrTamara's avatar

I have a sub specialty in epigenetic nutrition and I will have to print and study to get this ! Excellent work as usual , Jennifer !

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Carol_007's avatar

Im ready to throw out all supplements except Vit. D. after reading about NAC. I stopped NAC about a month ago after reading something negative, but this is too much. You think you're doing something good to help with your cancer and find out it can metastisize it. What other supplements are we causing harm with that we don't know about?

Thanks for the information, Jennifer.

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NatteringNaybob's avatar

JD - Not good but excellent stuff. "NAC treatment enhanced metastasis of lung cancer"

That kind of "bidirectional control" can be determined by the gene status (i.e. p53 null) and nature of the stress signal which triggers the cellular response.

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DrTamara's avatar

Excellent post ! I see some patients with excessive inflammation and heavy metal accumulation , where GSH formation has been hindered .this post makes me think twice before using excessive NAC to hinder mTOR. You certainly keep me on my feet ! Thank you .

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