And many other things that can disrupt the interconnected one-carbon methylation cycles. Post got too long for email. Methylation cycles are reviewed and there is a Retinoid Toxicity tangent.
Question: is doxorubicin resistance from NAC synonymous with protecting cancer cells? (If you don't have a doxorubicin-sensitive cancer to begin with, that is.)
From your link: "The exact mechanism of MRP1-involved multidrug resistance has not yet been clarified, although glutathione (GSH) is likely to have a role for the resistance to occur."
Part of my caution in using NAC is due to excess cysteine acting as a methylation cycle inhibitor - negative feedback control by cysteine on cysteine production in the cycles.
It didn't seem like the cancer articles I read were aware that their use of high dose NAC could be adding to cancer cell promotion by inhibiting proper epigenetic controls on genes by inhibiting methylation cycles.
My Cheerful Juice recipe didn't look like a recipe. It is the last section of a different post that I had linked to.
Section title: "Cheerful Juice recipe, an example of a health beverage individualized for BHMT gene dysfunction (DMG & methionine).
Approximately: 14 ounces water or herbal tea; 2 ounces of pomegranate juice; 1/2-1 teaspoon each: dimethylglycine (DMG) and methionine powder, 1/4-1/2 teaspoon each: lysine, N-acetylcysteine and taurine; a dash of baking soda; 1/4 teaspoon cardamom powder; 1/4-1/2 teaspoon Gotu kola powder; 1/2 teaspoon of vanilla extract; a teaspoon of stevia powder; a tablespoon of pure maple syrup.
I have been working on that mix for several years. The amino acid powders are acidic. Sweetener and the baking soda helps make it possible to drink. I sip it slowly over the day and keep it in a bottle in the refrigerator. Making a big glass and trying to drink it at once was too much acidity for my sensitive gut."
Oh my GOSH…
Suffice to say:
Everything in MODERATION?
Thanks so much for ALL YOUR research and information.
Helps one who chooses to, to make informed decisions.
You have help to improve the lifestyle of myself and others whom I share this valuable info with.
Yes, 'everything in moderation' is a good rule of thumb.
Spiritually too maybe, the Buddhist middle way rather than being extremely loose or extremely rigid about life.
Fully agree. I also caution against taking it habitually as it's just as good at protecting cancer cells from destruction as it is our own.
N-acetylcysteine enhances multidrug resistance-associated protein 1 mediated doxorubicin resistance
I Akan et al. Eur J Clin Invest. 2004 Oct.
https://pubmed.ncbi.nlm.nih.gov/15473893/
Question: is doxorubicin resistance from NAC synonymous with protecting cancer cells? (If you don't have a doxorubicin-sensitive cancer to begin with, that is.)
From your link: "The exact mechanism of MRP1-involved multidrug resistance has not yet been clarified, although glutathione (GSH) is likely to have a role for the resistance to occur."
As with the best questions they don't have all the answers yet, but this goes some way.
From Jen's latest Substack:
NAC, NAC, Knockin’ on Heaven's door: Interpreting the mechanism of action of N-acetylcysteine in tumor and immune cells (2022)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9563555/
Thanks.
I guess if one knows what type of cancer someone might get in advance, you would be more confident in treating autoimmune disorders with NAC!
Part of my caution in using NAC is due to excess cysteine acting as a methylation cycle inhibitor - negative feedback control by cysteine on cysteine production in the cycles.
It didn't seem like the cancer articles I read were aware that their use of high dose NAC could be adding to cancer cell promotion by inhibiting proper epigenetic controls on genes by inhibiting methylation cycles.
I don't suppose there were any studies of NAC + methyl donors.
At least, I didn't see any.
As a combined treatment approach?
As Jen says, pomegranate extract, for instance, is more failsafe.
Btw this also refers to BET protein inhibition, as per my latest Substack.
Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555619/
I’m sure I’m just missing it because I don’t see the mentioned recipe here 😭
My Cheerful Juice recipe didn't look like a recipe. It is the last section of a different post that I had linked to.
Section title: "Cheerful Juice recipe, an example of a health beverage individualized for BHMT gene dysfunction (DMG & methionine).
Approximately: 14 ounces water or herbal tea; 2 ounces of pomegranate juice; 1/2-1 teaspoon each: dimethylglycine (DMG) and methionine powder, 1/4-1/2 teaspoon each: lysine, N-acetylcysteine and taurine; a dash of baking soda; 1/4 teaspoon cardamom powder; 1/4-1/2 teaspoon Gotu kola powder; 1/2 teaspoon of vanilla extract; a teaspoon of stevia powder; a tablespoon of pure maple syrup.
I have been working on that mix for several years. The amino acid powders are acidic. Sweetener and the baking soda helps make it possible to drink. I sip it slowly over the day and keep it in a bottle in the refrigerator. Making a big glass and trying to drink it at once was too much acidity for my sensitive gut."
You are SUCH a darling! Thank you for sharing.
Very welcome!