Based on the binding affinity and molecular interaction patterns, five drugs, lumacaftor (-11.7 kcal/mol), conivaptan (-11.7 kcal/mol), betulinic acid (-11.6 kcal/mol), fluspirilene (-11.3 kcal/mol), and imatinib (-11.2 kcal/mol), have been ranked as the top drug compounds interacting with Mpox DdRp.
the human protein targets for MPXV have been identified accurately along with the detection of possible therapeutic targets. Furthermore, the validation process included conducting docking research studies on potential FDA drugs like Nicotinamide Adenine Dinucleotide and Hydrogen (NADH), Fostamatinib, Glutamic acid, Cannabidiol, Copper, and Zinc
If anyone doesn’t know not to listen to the white-coated charlatans by now, he deserves what happens.
Kind of but not really 😕 No one deserves experimental bioweapons.
Thanks
here's some I found,
Screening potential treatments for mpox from Traditional Chinese Medicine by using a data-driven approach
((quercetin) could stably bind to the target )
https://pubmed.ncbi.nlm.nih.gov/37713907/
Drug repurposing for Mpox: Discovery of small molecules as potential inhibitors against DNA-dependent RNA polymerase using molecular modeling approach
https://pubmed.ncbi.nlm.nih.gov/36946432/
Based on the binding affinity and molecular interaction patterns, five drugs, lumacaftor (-11.7 kcal/mol), conivaptan (-11.7 kcal/mol), betulinic acid (-11.6 kcal/mol), fluspirilene (-11.3 kcal/mol), and imatinib (-11.2 kcal/mol), have been ranked as the top drug compounds interacting with Mpox DdRp.
Chaga, white birch (Betula pubescens) (Ziziphus mauritiana), selfheal (Prunella vulgaris), jambul flowering quince (Pseudocydonia sinensis,rosemary,and Pulsatilla chinensis.
Structure based discovery of F. religiosa phytochemicals as potential inhibitors against Monkeypox (mpox) viral protein
six phytochemicals identified C-1
(kaempferol) and C-4 (piperine) as lead candidates.
A multi-targeted computational drug discovery approach for repurposing tetracyclines against monkeypox virus
https://pubmed.ncbi.nlm.nih.gov/37666979/
Overall, this study demonstrates the repurposing of tetracycline-derived drugs as a therapeutic solution for monkeypox viral infection.
https://www.thailandmedical.news/news/computational-study-identities-fda-approved-drugs-that-could-be-repurposed-to-treat-mpox-infections
nadh (nicotinamide-adenine-dinucleotide-hydride) was identified as a top candidate due to its strong binding affinity to mpox proteins
thai news article from,
Computational analysis of pathogen-host interactome for fast and low-risk in-silico drug repurposing in emerging viral threats like Mpox
https://pubmed.ncbi.nlm.nih.gov/39134619/
the human protein targets for MPXV have been identified accurately along with the detection of possible therapeutic targets. Furthermore, the validation process included conducting docking research studies on potential FDA drugs like Nicotinamide Adenine Dinucleotide and Hydrogen (NADH), Fostamatinib, Glutamic acid, Cannabidiol, Copper, and Zinc
Also check out,
https://www.thailandmedical.news/
looks to be a good resource,