Link to Glyphosate and Dioxin Detox - for soil remediation and human health, by Gavin Mounsey; also drugs that might fight Marburg viral infection.
... or Ebola, they seem to overlap. And phytonutrients/herbs that are antivirals against cold/flu/others.
Gavin Mounsey writes about soil remediation techniques and health care ideas for detoxing from glyphosate and dioxin. His post is very thorough and upbeat at the end - the more we love one another, the more power love has and it is good for our health and energy fields (aether/chi).
Soil remediation summary - (Mounsey, substack.com)
Soil remediation for glyphosate and dioxin could be the microbes in a healthy compost heap - make compost “tea” and apply some across the entire garden or field. The microbes do the rest of the work. Specific fungi are also mentioned in which case, once the mushroom “fruiting bodies” appear, remove them and discard as contaminated. Oyster mushrooms and other species are among the included references. The fungi preferentially uptake the dioxin. Like dandelion uptakes lead from contaminated soil.
Glyphosate and Dioxin Detox - by Gavin Mounsey (substack.com)
He excerpts from my self-care post about Vinyl Chloride, and adds more ideas. He is working on publishing a book on mitochondrial health - they are like the soil bacteria if we consider our cells to be like our garden soil.
We are symbionts - is a big point that standard medicine doesn’t appreciate enough yet. Methods in standard medicine tend to be offensive - kill something and hope that it doesn’t hurt too many healthy cells.
Glyphosate and Covid19
This Transcendingsquare post of mine has more information about glyphosate and has a focus on Covid-19. Glyphosate and COVID-19 - by Jenny (me) (substack.com)
Additional resource about dioxin via a reader email, “Excellent, thanks! Here's a page of resources aimed at solving the Norfolk bomb poisons:”
…Very welcome and thanks for the added info!
Drugs that may inhibit Marburg Virus adhesion and cell entry; see Table 1.
And just to stay ahead of the Feardemic media - Marburg virus is being discussed now. Via Pat in my Telegram chat group, (t.me/deNutrients/192?comment=33294):
Screening and Identification of Marburg Virus Entry Inhibitors Using Approved Drugs, (Zhang, et al., 2020) https://www.virosin.org/article/doi/10.1007/s12250-019-00184-3
See Table 1 for a list of 33 common drugs that were found to inhibit replication of a Marburg pseudovirus (modified to be less of a biohazard and able to be worked on within a Level 2 biosecurity lab). The pseudovirus has a glycoprotein surface marker of the Marburg virus, so the 33 drugs specifically would be targeting that glycoprotein of a Marburg virus.
“[Marburg Virus] MARV is a single-stranded negative-sense RNA virus. Its genome encodes seven proteins, of which the glycoprotein (GP) is the only membrane protein and is solely responsible for mediating virus adhesion and entry into host cells (Brauburger et al. 2012). Because GP is one of the key elements determining virus infection, it is therefore the main target of MARV drug, antibody and vaccine research.” (Zhang, et al., 2020)
“Finally, 33 hit compounds that had a SI[3 were considered to be effective in vitro (Table 1), with the two anti-malarial drugs, chloroquine phosphate and amodiaquine hydrochloride, exhibiting the highest SI values.
Over one third of the 33 hits were psychotropic substances, including antidepressant drugs, as well as drugs used to treat schizophrenia and drugs used to prevent migraines.
Eight compounds were proven antihistamine drugs,
while six were known to have anticholinergic activity.
Three compounds, including diltiazem hydrochloride, propafenone hydrochloride and amlodipine besylate, were calcium channel or sodium channel regulators, which modulate the cardiovascular system.
Nonsteroidal antiandrogen flutamide and corticosteroid budesonide were also identified as possible anti-MARV candidates (Table 1 and supplementary Fig. S1D).
Interestingly, many of the drugs identified against MARV clustered into categories similar to those identified in anti-EBOV screens reported by other groups, including anti-histamines, anticholinergics, estrogen receptor modulators, and drugs that affect the brain, nervous, and cardiovascular systems (Kouznetsova et al. 2014; Bai and Hsu 2018).
It is also important to note that, because of the nature of the pseudovirus system, the screens used in this study targeted MARV GP specifically. Thus, the positive hits that were identified likely targeted the attachment or entry step of virus infection, whereas drugs targeting other steps of MARV infection, such as replication or release, could not be identified in this study.” (Zhang, et al., 2020) [Bullet points added by me, for emphasis.)
Ebola virus and Marburg virus drugs seem to overlap somewhat (see their Table 1).
Marburg and Ebola viruses are both Filoviruses. Another paper on therapeutic strategies for Ebola Virus includes GP inhibitors its Table 1: (Liu, Hu, Wong, Lin, 2022)
These are both articles about medications and phytonutrients are more my thing.
Phytonutrients / super foods as antivirals - flu strains and others.
Pomegranate peel extract for H1N1, H3N2, and H5N1 flu strains, green tea EGCG combined with vitamin C and licorice are also highlighted in this comprehensive review article on phytonutrients as anti-virals. Marburg and Ebola are not mentioned though. (Saifulazmi, et al., 2022) Pomegranate peel is intriguing.
“The importance of phenolic acids, alkamides, alkylamides, glycyrrhizin, [licorice root] epicatechin gallate (ECG), epigallocatechin gallate (EGCG), epigallocatechin (EGC), [pomegranate and green tea have catechins] protein-based plant-produced ZIKV Envelope (PzE), and anti-CHIKV monoclonal antibody was also reviewed.” […]
Pomegranate: “The potent antiviral activity of polyphenols (PP) components of pomegranates inactivated influenza virus (H1N1 and H3N2 influenza viruses and reassortant H5N1 virus rg-VN/04) through a direct effect on the viral particle [56]. Viral inactivation by PP was the result of damage to virion structural integrity, and complete influenza inactivation was shown with the treatment of 1600 μg/mL of PP. Intriguingly, even the treatment of 400 μg/mL PPs for 5 min showed a 99% virus reduction.” …]
Licorice root: “Glycyrrhizin, a triterpene saponin, is an active constituent of licorice root. Notably, H5N1-induced cytokine expression and H5N1-induced caspase activation were reduced.”
Green Tea Extract plus vitamin C: “The addition of ascorbic acid (as an antioxidant) to [Green Tea Extract] GTE was found to prolong the duration of the virucidal properties of GTE. Among three polyphenolic compounds of green tea viz. (−)-epigallocatechin gallate (EGCG), (−)-epicatechin gallate (ECG), and (−)-epigallocatechin (EGC), EGCG and ECG were found to be potent inhibitors of various influenza virus subtypes (including influenza A/H1N1, A/H3N2 and B virus) replication in MDCK cell culture. […] The study also suggested that the virucidal properties of catechin were due to the altering physical integrity of the membrane of host cells or the virus particles [67].”
Bolded points:
Catechins in pomegranate peel, green tea, and other foods like goji berries and sumac and avocado seed flour, inhibit viral replication by literally breaking the virus membrane / physical structure - nice to know!
Adding Vitamin C, ascorbic acid, increased the antiviral potency of Green Tea Extract.
The review includes several Tables and graphic summaries of the most useful herbs for cold virus, flu, mosquito borne illnesses, and sexually transmitted virus. Topical herbs are included. Aloe vera is mentioned. (Saifulazmi, et al., 2022)
This article includes symptoms of Ebola/Marburg illness and mentions Remdesivir as a treatment - so caution with the advice: Marburg vs. Ebola Virus: Symptoms, Treatment, Life Expectancy (emedicinehealth.com)
The main treatment for both Marburg virus and Ebola virus infections includes supportive care, including:
Rehydration with oral or intravenous fluids
Maintenance of blood volume and electrolyte balance
Replacement of depleted coagulation factors
Minimization of invasive procedures
Treatment of specific symptoms, including use of pain medications.
Marburg vs. Ebola Virus: Symptoms, Treatment, Life Expectancy (emedicinehealth.com)
Rehydration support means non-diuretic liquids AND sodium, potassium, and magnesium; and maybe calcium too but it can be in excess during inflammation. Sweat, vomit, diarrhea - all are a loss of fluid and electrolytes. Pedialyte beverages or popsicles are better balanced for hydration support than sports drinks made for rehydration as they don’t have adequate magnesium frequently.
Replacement of depleted coagulation factors would include vitamin K2. Treatment of specific symptoms might also include anti-histamines and Nrf2 promoters which can help reduce the inflammation that increases pain signaling.
Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
Reference List
(Liu, Hu, Wong, Lin, 2022) Liu CH, Hu YT, Wong SH, Lin LT. Therapeutic Strategies against Ebola Virus Infection. Viruses. 2022 Mar 11;14(3):579. doi: 10.3390/v14030579. PMID: 35336986; PMCID: PMC8954160. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8954160/
(Saifulazmi, et al., 2022) Saifulazmi NF, Rohani ER, Harun S, Bunawan H, Hamezah HS, Nor Muhammad NA, Azizan KA, Ahmed QU, Fakurazi S, Mediani A, Sarian MN. A Review with Updated Perspectives on the Antiviral Potentials of Traditional Medicinal Plants and Their Prospects in Antiviral Therapy. Life (Basel). 2022 Aug 22;12(8):1287. doi: 10.3390/life12081287. PMID: 36013466; PMCID: PMC9410304. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410304/
Singleton C.D., Humby M.S., Yi H.A., Rizzo R.C., Jacobs A. Identification of Ebola Virus Inhibitors Targeting GP2 Using Principles of Molecular Mimicry. J. Virol. 2019;93:e00676-19. doi: 10.1128/JVI.00676-19. [PMC free article] (Reference 60 in (Liu, Hu, Wong, Lin, 2022)
(Zhang, et al., 2020) Li Zhang, Shan Lei, Hui Xie, Qianqian Li, Shuo Liu, Qiang Liu, Weijin Huang, Xinyue Xiao, Youchun Wang. Screening and Identification of Marburg Virus Entry Inhibitors Using Approved Drugs [J].VIROLOGICA SINICA, 2020, 35(2) : 235-239. http://dx.doi.org/10.1007/s12250-019-00184-3 https://www.virosin.org/article/doi/10.1007/s12250-019-00184-3
Looks like a fairly exhaustive list of all the viruses that were supposed to wipe mankind from the face of the planet in the 21st century.
Interesting to see chloroquine as quite active. No doubt the CDC will shout hosanna and bless it.