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Aʟᴢʜᴇɪᴍᴇʀ Exᴘᴇʀᴛ & Bʀᴀɪɴ Mɪᴄʀᴏʙɪᴏᴍᴇ Exᴘᴇʀᴛ

🦠ʙʀɪᴅɢɪɴɢ ᴘʀᴏʙɪᴏᴛɪᴄꜱ ᴀɴᴅ ᴀʟᴢʜᴇɪᴍᴇʀ'ꜱ ʀᴇꜱᴇᴀʀᴄʜ🧠

Frank Bernier, PhD, MSc, CIP

https://www.linkedin.com/posts/francois-bernier-phd_centunarian-microbiome-diversity-activity-7064043227506491392-36K_

Centenarian Secret Unveiled: Gut Viruses May Bolster Immunity Against Pathogens

Fresh insights propose that individuals living to a hundred or beyond — known as centenarians — harbor a wide array of viruses in their gut microbiome that may bolster their resilience against infectious diseases.

The study, unveiled today in the journal Nature Microbiology, elucidates some of the biological mechanisms potentially contributing to the longevity and robust health of centenarians.

The research, spearheaded by Joachim Johansen, Ramnik Xavier, Simon Rasmussen, and Damian Plichta at the Broad Institute of MIT and Harvard, delved into the viromes — the viral genetic material — of 195 participants from Japan and Sardinia. The results revealed that centenarians exhibit a richer diversity of gut microbiota, including bacteria and viruses.

Moreover, the team discovered that viruses prevalent in centenarians bolstered the capacity of beneficial gut bacteria to metabolize sulfate, a process that could enhance the gut's innate defenses against bacterial infections.

This study contributes to the burgeoning knowledge affirming the critical role of the dynamic interplay among bacteria, viruses, and fungi within the gut microbiome in warding off age-related ailments.

Centenarians have a diverse gut virome with the potential to modulate metabolism and promote healthy lifespan

https://www.nature.com/articles/s41564-023-01370-6

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Dr. Amine ZORGANI

On a Mission to SAVE the Human Microbiome from Extinction | Inventor | Speaker | Author | Producer

https://www.linkedin.com/posts/amine-zorgani_mysummary-mythoughts-myinspiration-activity-7078975172656943104-dPAh

A Groundbreaking Study From Stanford University School of Medicine: The Missing Microbes From Industrialized Populations Were Finally Found!

MY SUMMARY

In an unprecedented study published in Cell Press, the couple Sonnenburg analyzed the gut microbiomes of 167 Hadza hunter-gatherers from Tanzania.

The researchers conducted ultra-deep metagenomic sequencing on 351 fecal samples from the Hadza community, as well as comparative populations in Nepal and California.

Top highlights of the study:

🔹The Hadza displayed significantly higher gut microbial diversity, with an average of 730 species per person, compared to 277 species in Californians and an intermediate number in Nepali individuals.

🔹The Hadza microbiomes contained unique species, such as Treponema succinifaciens, which were absent or declining in the other populations due to industrialization.

🔹The study revealed 124 gut-resident species that are vanishing in industrialized populations!

MY THOUGHTS

Almost a week ago I shared a post with the title "50% Of The Gut Microbes In Our Primate Ancestors Deserted Us!" (1).

There was an interesting thought from Dr. Daniel Sanders:

"Maybe we need to harvest from groups that have the most diverse and beneficial microbiomes-grow them and keep a bank of them for further study. Eventually, maybe even a small pilot re-seeding project once we are 1000% sure it’s safe."

This was my reply back then to him:

"Dr. Daniel Sanders there are some studies that showed that the microbiomes of Hunter-gatherer tribes are more diverse compared to those who live in the city. There is also evidence of the diversity of the gut biome of centenarians. Maybe we can collect them... however, growing them without losing diversity is a very big task...more importantly, since we already lost 50% of them...our gut may refuse them as the whole ecosystem is different now! But it's worth the shot!"

Did I read the future of today's post? Maybe! Should we really go and "mess" with the Hunter-gatherer's microbiome to save ours? Maybe not!

HAPPY To Hear Your THOUGHTS and Stay POSITIVE!

Ultra-deep sequencing of Hadza hunter-gatherers recovers vanishing gut microbes

https://www.cell.com/cell/fulltext/S0092-8674(23)00597-4

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