Mitochondrial Medicine textbook - I bought it used and it is a signed copy! *Yes, I have been buying a lot of books, so I got myself a library card. So many books, so little time.
JD - Good to hear your doing better. At intermediate doses (1000mgd) Niacin will increase HDL cholesterol levels +15 to 30%.
HDL transports lipids to hepatic cells and the majority of HDL associated cholesterol is destined for biliary excretion. Cholesterol is excreted into the bile directly or after conversion to bile acids.
Higher niacin doses (3000 mgd) may cause jaundice, abdominal discomfort, blurred vision, worsening of hyperglycemia, and precipitation of preexisting gout.
As niacin overload can overwork the liver and result in hepatoxicity, people with a liver disorder probably should not take high dose niacin.
It may not be gallstones, but that pathway is tied in to whatever is going on viz. +niacin = +HDL = +bile & +uric acid
"Yes, I have been buying a lot of books, so I got myself a library card. So many books, so little time." Brought this to mind... https://youtu.be/UAxARJyaTEA?t=97
Thanks, still have to look at the link, but I was thinking I should try to wean down my niacin dose a little and see if that helps . . . once I get through the serotonin level changes. (I get teary over everything when my serotonin drops and the niacin helps support serotonin.)
JD - Good to hear your doing better. At intermediate doses (1000mgd) Niacin will increase HDL cholesterol levels +15 to 30%.
HDL transports lipids to hepatic cells and the majority of HDL associated cholesterol is destined for biliary excretion. Cholesterol is excreted into the bile directly or after conversion to bile acids.
Higher niacin doses (3000 mgd) may cause jaundice, abdominal discomfort, blurred vision, worsening of hyperglycemia, and precipitation of preexisting gout.
As niacin overload can overwork the liver and result in hepatoxicity, people with a liver disorder probably should not take high dose niacin.
It may not be gallstones, but that pathway is tied in to whatever is going on viz. +niacin = +HDL = +bile & +uric acid
"Yes, I have been buying a lot of books, so I got myself a library card. So many books, so little time." Brought this to mind... https://youtu.be/UAxARJyaTEA?t=97
My reaction: "Oh, the horror!"
That really isn't fair. I was unfamiliar with that episode. haha
nightmare scenario ;-)
Thanks, still have to look at the link, but I was thinking I should try to wean down my niacin dose a little and see if that helps . . . once I get through the serotonin level changes. (I get teary over everything when my serotonin drops and the niacin helps support serotonin.)