Thanks NN - had a rough couple days. Agree that the butyrate producers seem key to overall health - or stress coping skills of the emotional and physical/internal sort. Stress -> gut dysbiosis -> mitochondrial dysfunction -> loss of epigenetic control -> out of control cells doing odd things.
That is a very well done article, thorough without being way long like my posts tend to be.
An Akkermansia product is among the examples in my Protocol. I have tried it. Needs to be refrigerated so I was never good at taking it consistently. Pomegranate helps support that and other good species while knocking our bad ones and yeast. Dr. Mercola does mention "polyphenol rich fruit".
I was unfamiliar with akkermansia until today, and while browsing ScienceDirect the first page of results returned hits for my old friends astaxanthin and berberine:
"In contrast, oral administration of AST increased the relative abundance of A. muciniphila, and oral supplementation with A. muciniphila also alleviated inflammation and pain in EAP mice. Finally, we demonstrated that both AST and A. muciniphila interventions increased serum levels of SCFAs acetate, up-regulated expression of colonic tight junction markers, and decreased serum lipopolysaccharide levels in EAP mice."
"Astaxanthin stimulates the production of cuprocytes and mucus in the intestines by promoting the proliferation of Akkermansia. In addition, astaxanthin enhances the intestinal mucosal immunological function. Our research supports the unique ability of astaxanthin to sustain intestinal flora homeostasis and its function as a dietary immune booster for individuals with tumors.'
"Berberine was an effective agent in treating UC with the mediation of the IM. This conclusion was followed by the results that BBR significantly increased the diversity and community of IM and promoted the abundance of specific flora, including f__Muribaculaceae, Bacteroides, Dubosiella, Allobaculum and Akkermansia. The increasing abundance of Bacteroides and Akkermansia enhanced intestinal barrier function..."
JD - Excellent dysbiosis discourse. No surprise that a lack of endogenous butyrate producing species has been linked to cancer.
Thanks NN - had a rough couple days. Agree that the butyrate producers seem key to overall health - or stress coping skills of the emotional and physical/internal sort. Stress -> gut dysbiosis -> mitochondrial dysfunction -> loss of epigenetic control -> out of control cells doing odd things.
A recent Mercola article has tips on how to restore the microbiome and mitochondria:
https://takecontrol.substack.com/i/144267044/how-to-restructure-your-microbiome
That is a very well done article, thorough without being way long like my posts tend to be.
An Akkermansia product is among the examples in my Protocol. I have tried it. Needs to be refrigerated so I was never good at taking it consistently. Pomegranate helps support that and other good species while knocking our bad ones and yeast. Dr. Mercola does mention "polyphenol rich fruit".
I was unfamiliar with akkermansia until today, and while browsing ScienceDirect the first page of results returned hits for my old friends astaxanthin and berberine:
"In contrast, oral administration of AST increased the relative abundance of A. muciniphila, and oral supplementation with A. muciniphila also alleviated inflammation and pain in EAP mice. Finally, we demonstrated that both AST and A. muciniphila interventions increased serum levels of SCFAs acetate, up-regulated expression of colonic tight junction markers, and decreased serum lipopolysaccharide levels in EAP mice."
https://www.sciencedirect.com/science/article/abs/pii/S0944711323006086
"Astaxanthin stimulates the production of cuprocytes and mucus in the intestines by promoting the proliferation of Akkermansia. In addition, astaxanthin enhances the intestinal mucosal immunological function. Our research supports the unique ability of astaxanthin to sustain intestinal flora homeostasis and its function as a dietary immune booster for individuals with tumors.'
https://www.sciencedirect.com/science/article/abs/pii/S1567576924000717
"Berberine was an effective agent in treating UC with the mediation of the IM. This conclusion was followed by the results that BBR significantly increased the diversity and community of IM and promoted the abundance of specific flora, including f__Muribaculaceae, Bacteroides, Dubosiella, Allobaculum and Akkermansia. The increasing abundance of Bacteroides and Akkermansia enhanced intestinal barrier function..."
https://www.sciencedirect.com/science/article/abs/pii/S0024320523010202
Always nice to get confirmation that I'm on the right track!
I think they like bitter phytonutrients in general - bitter taste receptors do stuff besides taste.
A quick check for akkermansia on amazon returned not one single brand that looked legit.
Which one did you try?
It is a newer product and company. Pendulum, I found them through FullScript. https://pendulumlife.com/products/pendulum-akkermansia?utm_source=bing&utm_medium=paid&utm_campaign=acquisition_brand_akkermansia_b_32c4dd3c36e6377c6027231124ace35b&utm_term=pendulum%20akkermansia&msclkid=491b6fd6187e1773d3bc0995395d158a A mother who worked hard to develop a product that would help her own special need child.
Excellent article as always! Thanks Jennifer…very informative read.