Functional foods that may be effective against spike effects at the ACE2 receptor in particular.

Rough dosing/use directions for: Dandelion, Pomegranate peel, Baicalin, Artemisinin/Sweet Wormwood, Black seed oil, Citrus peel, Licorice root (non-DGL, whole root dried and powdered).

More details on the herbs mentioned in the blurb above follows this condensed list, references, full query Thread is here/x.com, IgG4 is the topic of the Thread, by Angela Rhoten, more about that is also included later. Check my archives for a variety of posts I’ve written on Ig4 I think I called it rather than IgG4. ???

Here's a compact list combining the earlier information with the newly added details, focusing on brevity for use directions:

Supplements:

• Nattokinase: From natto, fibrinolytic, potential for breaking down spike proteins.

• Bromelain: Pineapple enzyme, reduces inflammation, might degrade spike proteins.

• Curcumin: From turmeric, anti-inflammatory, studied for inactivating spike proteins.

• N-Acetyl Cysteine (NAC): Breaks down mucus, supports respiratory health.

• Vitamin D: Boosts immune function.

• Vitamin C (High Dose): Antioxidant, immune support.

• Zinc: Inhibits viral replication.

Pharmaceuticals:

• Ivermectin: Antiparasitic, controversial antiviral use.

• Dexamethasone: Corticosteroid, reduces inflammation.

• Antiviral Drugs (like remdesivir): Manage viral load.

Herbal Remedies:

• Dandelion Extract: Inhibits SARS-CoV-2 in vitro. Use: 4-10 grams of leaves in tea, three times daily.

• Green Tea Extract: Contains EGCG, blocks viral entry.

• Ginger: Anti-inflammatory. Use: Fresh or tea for digestion and inflammation.

• Pau d'Arco: Suggested antiviral, anecdotal.

• Oregano: Antimicrobial, potential antiviral.

• Olive Leaf Extract: Antiviral capabilities.

• Baicalin (Skullcap): Inhibits furin. Use: About 10 grams in tea.

• Artemisinin (Sweet Wormwood): Interferes with viral entry/replication. Use: 10 grams dried leaf for malaria prevention, caution advised.

• Nigellidine (Black Seed): Binds to spike protein. Use: Black seed oil by spoonful or topically.

• Citrus Fruits (Nobiletin/Neohesperidin): Blocks spike protein binding. Use: Inner pith for congestion relief.

• Licorice Root (Glycyrrhizin): Blocks spike-ACE2. Use: Powder in beverages, 1/4 teaspoon a few times daily.

• Pomegranate Peel/Extract: Inhibits spike-ACE2 interaction. Use: Peel in tea or extract; diuretic, consume extra water, use earlier in the day.

Natural Foods:

• Garlic: Immune support, antimicrobial.

• Berries: Polyphenols reduce viral replication.

• Turmeric (Fresh): Contains curcumin, supports immunity.

• Honey: Antibacterial, anti-inflammatory.

Creative Combinations:

• Spicy Anti-Spike Tea: Ginger, turmeric, black pepper, honey, lemon.

• Herbal Detox Smoothie: Spinach, berries, pineapple, green tea/dandelion.

• Natto Bowl: Natto with veggies, garlic, ginger.

Note: Consult healthcare providers before new treatments. Some suggestions are based on preliminary or traditional use.

Disclaimer: Grok is not a doctor; please consult one. Don't share information that can identify you.

Dandelion (Taraxacum officinale)

Key Phytonutrients: Sesquiterpene lactones, triterpenes, phenolic compounds, polysaccharides.

Mechanism of Action: Blocks the interaction between SARS-CoV-2 spike protein and ACE2 receptor, potentially inhibiting viral entry.

Dosing for Layperson: 4-10 grams of dried dandelion leaves steeped in hot water, up to three times per day.

Leaves, roots, flowers and stems, all have the medicinal phytonutrient. Early spring leaves are tasty in salads. It is a bitter accent, cut the leaves into small pieces and toss with other greens and a little fruit for a sweet accent can be nice - a few strawberries or pomegranate seeds or chopped pear. Photo by Walter Sturn on Unsplash

Pomegranate (Punica granatum)

Key Phytonutrients: Punicalagin, punicalin, ellagic acid.

Mechanism of Action: Inhibits the binding of SARS-CoV-2 spike protein to ACE2 receptor, showing efficacy in blocking viral entry with various compounds contributing.

Dosing for Layperson: Not specifically mentioned, but generally, pomegranate juice or peel extract can be consumed. For peel extract, further research is needed for exact dosing. Anecdotally, the inner pith is a milder, lower tannin content, functional food and source of pectin and other gut microbiome supporting factors. The whole peel generally has proven superior to isolated phytonutrients for various conditions. The whole peel can be made into tea or a stronger alcohol or water based extract and used in small amounts as desired. It is a strong diuretic and extra water should be consumed during the day too. Have the pomegranate peel products earlier in the day, once or a few times as desired. An excess would be an irritant as well as causing increased diuretic effects so caution is needed with use. It could affect someone with salicylate sensitivity as it is a COX2 inhibitor/antioxidant as are many phytonutrients listed here.

Baicalin (from Scutellaria baicalensis, Skullcap)

Key Phytonutrients: Baicalin (a flavone glycoside).

Mechanism of Action: Inhibits furin, an enzyme that cleaves the SARS-CoV-2 spike protein, potentially reducing viral infectivity.

Dosing for Layperson: No specific dosing mentioned; typically, skullcap is used in teas or supplements, but exact amounts for this context aren't specified. Anecdotally, skullcap leaf herb might be made into tea using a spoonful, about 10 grams, in a pot of hot water and drunk over the course of the day.

Artemisinin (from Artemisia annua, Sweet Wormwood)

Key Phytonutrients: Artemisinin.

Mechanism of Action: May interfere with SARS-CoV-2 entry or replication, though less specific to spike protein interaction.

Dosing for Layperson: Not detailed in the context provided; traditionally, artemisinin is used in malaria treatment, but for viral inhibition, more research is needed. Anecdotally or traditional use in malaria endemic regions, people use about 10 grams of dried leaf of Artemesia species made into tea once a day as a prevention against malaria. Wormwood is a source of thujone which affects GABA receptors, may be habit forming, and can cause seizures in excess. Sweet Wormwood is typically used for tea or malaria prevention although it is not recommended for women in childbearing age groups. Artemesia afra may be used in traditional malaria regions by women of child-bearing age, or during pregnancy and lactation.

Nigellidine (from Nigella sativa, Black Seed)

Key Phytonutrients: Nigellidine (an indazole-type alkaloid).

Mechanism of Action: Binds to the SARS-CoV-2 spike protein, potentially blocking its interaction with ACE2, and interacts with angiotensin-related proteins to manage vascular effects.

Dosing for Layperson: Not specified in the context; Nigella sativa is generally used in seed form, oil, or as an extract supplement, but specific dosing for this use isn't detailed. Anecdotally and traditional use, black seed oil may be taken by spoon or added to food although the flavor is strong. A spoonful goes down faster. It is high in salicylates and should be avoided by people sensitive to salicylate excess. Anecdotally, black seed oil is also helpful as a topical pain relieving and antimicrobial or anti-inflammatory agent on shingles or Monkeypox type skin outbreaks.

Citrus Fruits (for Nobiletin and Neohesperidin)

Key Phytonutrients: Nobiletin, Neohesperidin.

Mechanism of Action: Both can potentially block spike protein binding to ACE2.

Dosing for Layperson: Not specified; citrus fruits can be consumed regularly, but for therapeutic purposes, further study is needed. Anecdotally, eating the inner pith with the fruit slices can reduce congestion for about 6 hours. The outer zest layer has oxalate and should not be consumed in large amounts. 1/2 to 1 teaspoon minced on food is a medicinal dose, anectdotally. Gently simmer peel in water for 20 minutes, strain and use spoonfuls of the concentrate as desired. The bitter taste becomes unpleasant as more is consumed, making it a natural safety mechanism to use as a food rather than capsule product.

Licorice Root (for Glycyrrhizin)

Key Phytonutrients: Glycyrrhizin.

Mechanism of Action: Blocks spike protein interaction with ACE2.

Dosing for Layperson: Not detailed; licorice root can be consumed in tea form or as a supplement, but caution is advised due to potential side effects with overuse. Anecdotally, licorice root powder can be added directly to hot water for a slightly sweet and licorice flavored beverage. The powder can also be used to flavor and sweeten baked goods or added to pudding or other dishes. A medicinal amount for adrenal support might be a 1/4 teaspoon a few times per day (approximately a few hot beverages or a 200 mg capsule product once or a few times per day) Whole root, powdered, or non-DGL licorice root would be the product to look for to block ACE2 from spike.

hot cup of tea with a pomegranate and an orange nearby and a small vase of Dandelions *AI generated image, with Oxtail daisies, pretty close. It looks like a Clementine tangerine rather than a large Navel orange next to the pomegranate and cup of herbal tea.

This list is added at the end of a long series of queries by Angela Rhoten regarding IgG4 related conditions and spike effects, herbal or other treatments that might help and a layperson summary towards the end. I add some pomegranate and phytonutrient additions after that. Link/x.com. Angela helped with editing of a research paper on IgG4 and spike effects. Bio about Angela and the paper linked in this x.com post.

The paper and the series of Grok queries suggests that repeated exposure, more boosters or passive exposure will worsen IgG4 related effects:

• Uversky VN, Redwan EM, Makis W, Rubio-Casillas A. IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein. Vaccines. 2023; 11(5):991. https://doi.org/10.3390/vaccines11050991 https://www.mdpi.com/2076-393X/11/5/991

~~ Supporting material:

Unfortunately, the URL you provided (https://soundofstars.org/bioactives.htm) doesn't lead to a functional webpage, as it appears to be a frames-based site that my system can't directly access or interpret. However, using the information from related web results that I have access to, I can summarize the general content related to natural products and their bioactivities, particularly in the context of viral infections like SARS-CoV-2:

Summary of Natural Bioactives Against Viral Infections:

Dandelion (Taraxacum officinale):

• Contains a broad spectrum of phytochemicals including sesquiterpene lactones, triterpenes, phenolic compounds, and polysaccharides.

• SARS-CoV-2: Water-based extracts from dandelion leaves have shown the ability to block the binding of SARS-CoV-2 spike protein to the ACE2 receptor, with high molecular weight compounds being particularly effective.

Pomegranate (Punica granatum):

• Rich in punicalagin, punicalin, and other polyphenols.

• SARS-CoV-2: Pomegranate peel extract has been found to inhibit the binding of the SARS-CoV-2 spike protein to ACE2 receptors in vitro, suggesting potential antiviral properties.

Baicalin (from Scutellaria baicalensis, Skullcap):

• Known for its anti-inflammatory and antiviral effects.

• SARS-CoV-2: Baicalin can inhibit the activity of furin, an enzyme involved in the cleavage of the SARS-CoV-2 spike protein, potentially reducing viral infectivity.

Artemisinin (from Artemisia annua, Sweet Wormwood):

• Famous for its antimalarial properties but also shows broad antiviral activity.

• SARS-CoV-2: Artemisinin derivatives have been investigated for their ability to interfere with SARS-CoV-2 entry into cells or viral replication processes.

Additional Natural Products Mentioned:

• Chicoric Acid, Taraxasterol, Chlorogenic Acid from Dandelion: These components have potential anti-inflammatory and antiviral properties, which might be relevant in managing viral infections.

• Withametelin and Daturaolone from Datura innoxia: While withametelin showed toxicity, daturaolone was noted for lower toxicity and potential antiviral activity against SARS-CoV-2.

General Observations:

• These natural compounds are explored for their potential to interact with viral proteins, inhibit key enzymes, or modulate immune responses in ways that could prevent or mitigate viral infections.

• Many of these studies are in vitro, meaning the effects are observed in controlled lab conditions rather than in living organisms.

• The presence of high molecular weight compounds in some extracts (like dandelion) suggests that the complexity of natural products might offer multiple mechanisms of action against viruses.

• While these natural products show promise, translating these findings into practical, safe, and effective treatments for humans requires further in vivo studies and clinical trials to determine dosage, efficacy, and safety.

Please note, this summary is pieced together from the available information and might not cover all details of the article you linked due to the inaccessible nature of the webpage. Always consult with healthcare providers before starting any new treatment or supplement regimen, especially in the context of managing or preventing viral infections.

~~

Here's a summary of the content you've provided from the BioRxiv preprint and the related article:

Title: As vaccines weaken herd immunity, natural herbs promise true prevention, more substantial immunity

Key Points:

• Dandelion (Taraxacum officinale):

  • A German university study highlighted that dandelion can block the SARS-CoV-2 spike protein from binding to the ACE2 receptor on human lung and kidney cells. This was effective against various mutations of the spike protein, including those from significant variants like B.1.1.7 (UK), B.1.351 (South Africa), and P.1 (Brazil).

  • The study used water-based extracts from dried dandelion leaves, focusing on high molecular weight compounds. These compounds inhibited the interaction between the spike protein's S1 subunit and the ACE2 receptor.

• Other Natural Compounds:

  • Nobiletin (from citrus peels), Neohesperidin (from citrus fruits), and Glycyrrhizin (from licorice root) have also been shown through molecular docking studies to prevent the spike protein from binding to ACE2 receptors.

  • Pomegranate Peel Extract: Demonstrated significant efficacy in blocking the spike protein-ACE2 interaction, with an overall efficacy of 74%. Its main components, punicalagin and ellagic acid, individually showed 64% and 36% effectiveness, respectively.

• Safety and Usage:

  • These natural compounds are generally considered safe for consumption. There's no known overdose risk with dandelion leaf extract.

  • The European Scientific Cooperative on Phytotherapy suggests a dosage of 4-10 grams of dandelion leaf steeped in hot water, up to three times a day.

• Implications:

  • The article argues that these natural extracts could be mass-produced and used as preventive measures against current and future variants of the SARS-CoV-2 virus.

  • There's an implication that reliance on vaccines might not be as effective for achieving herd immunity, suggesting natural remedies could offer a more substantial or complementary form of immunity.

Caveats and Considerations:

• The BioRxiv article you linked is a preprint, meaning it's a preliminary version of the research that has not yet undergone peer review. Preprints can provide early insights but should be interpreted with caution until peer-reviewed.

• The statement about vaccines weakening herd immunity is controversial and not supported by the mainstream scientific consensus, which generally views vaccines as crucial for achieving herd immunity against infectious diseases.

• The effectiveness of these natural compounds in vivo (in living organisms) versus in vitro (in test tubes) needs further exploration to confirm their practical use in humans.

• While these compounds show promise in blocking viral entry, they are part of a broader strategy rather than a standalone solution for preventing or treating viral infections.

This summary reflects the information provided but remember, the science of natural compounds in medicine is complex, and their practical application requires rigorous clinical evaluation to ensure safety and efficacy in human use.

~~

Here's a summary of the content regarding nigellidine and its potential role in mitigating the effects of SARS-CoV-2:

Title: In silico Nigellidine (N. sativa) bind to viral spike/active-sites of ACE1/2, AT1/2 to prevent COVID-19 induced vaso-tumult/vascular-damage/comorbidity

Key Points:

• Nigellidine Structure:

  • Nigellidine is an indazole-type alkaloid from Nigella sativa (black seed), with the chemical structure described by the molecular formula C18H18N2O2 and a molecular weight of 294.3 g/mol. Its 3D structure was retrieved from PubChem and converted for use in computational studies.

• Binding to SARS-CoV-2 Spike Protein and ACE2:

  • Spike Protein: Nigellidine binds strongly at the hinge region or active site of the spike protein, potentially disrupting the interaction with the ACE2 receptor on host cells, which could inhibit viral entry.

  • ACE2: It binds with significant affinity to the angiotensin II binding site of ACE2, with a binding energy of -7.54 kcal/mol and an Atomic Contact Energy (ACE) value of -211.76, suggesting it might block the viral entry mechanism more effectively than some known compounds like EGCG or Theaflavin-di-gallate.

• Interaction with ACE1 and Angiotensin Receptors:

  • ACE1: Nigellidine also binds to ACE1, both in monomeric and multimeric forms, with a binding energy of -5.48 kcal/mol, potentially affecting the balance between vasoconstriction and vasodilation.

  • AT1/AT2 Receptors: It shows binding to angiotensin receptors AT1 and AT2, which could influence the inflammatory and vascular responses associated with COVID-19 by blocking these receptors.

• Potential Benefits:

  • By blocking these angiotensin-related proteins, nigellidine might help restore normal angiotensin levels, reduce vascular turbulence, and prevent inflammatory or vascular damage in COVID-19 patients, particularly those with comorbidities like hypertension, diabetes, or cardiac and renal impairments.

• Implications:

  • The study suggests that nigellidine could be particularly beneficial for elderly patients or those with comorbidities who are at higher risk of severe outcomes from COVID-19. The compound's interaction with multiple targets involved in the renin-angiotensin system might help manage the systemic effects of the virus.

Caveats and Considerations:

• This study is based on in silico (computer simulation) data, which, while providing insights into potential interactions, needs in vitro (lab) and in vivo (live organism) validation to confirm these effects in real-world scenarios.

• The binding affinities and energies mentioned are theoretical and should be interpreted with caution until supported by experimental evidence.

• The article from PMC (PubMed Central) you linked to provides a comprehensive look at the potential of nigellidine, but its practical application in treatment or prevention would require further research, including clinical trials to assess safety, efficacy, dosage, and potential interactions with other medications or health conditions.

This summary reflects the information from the content you provided but remember that the translation from computational chemistry to clinical use involves many steps, each with its challenges and uncertainties.

Disclaimer: This information is being provided for educational purposes within the guidelines of Fair Use and is not intended to provide individual health care guidance.