Digestive & mental health discussion & Thanks for the well wishes.
I am feeling better today. / Ferroptosis and mast cell degranulation.
I appreciate the suportive comments on my last post. And it was mentioned that Marie Zee has also had her banking accounts disabled.
When over the target, the enemy increases the flak.
I saw a TikTok video yesterday with a LongCovid or vak injured woman crying about her digestive and other misery and wondering when someone/some agency/gov/industry was going to care and do something to help? I reshared the video with a sad reality check - no one officially is going to do anything to help. The misery is no big deal or desirable even if culling the population is the goal as it seems to be.
Independent activists have been trying very hard and often at their own financial expense like Dr Hazan to help shed light on what the chimeric spike is doing and what might help reduce those effects.
I have also kept my work personally financed - low budget. Dr. Mercola and Marie Zee are going to have employees and deadlines and duties to meet which lack of financial accounts will impact.
I promote low budget grocery store or foraging type solutions because they can’t be banned as readily as a medication or OTC supplement.
We are not playing with kid gloves on - this is bare-fisted Fight Club. Since money is a big control over individuals, my approach to being ‘cancelled’ was to not try to make money. I just have tried to provide user friendly information that people might find for themselves with the search engine.
Regarding my recent health difficulties - I cried some yesterday too. The TikTok woman is correct - it would be nice to have real guidance and even direct help.
My health goofs - 1: xanthum gum - digestive upset, that got a little better (July 23, post) but then 2: the solanine/carotenoid day (July 25, post) led to the next day with the bad flu-like body aches, (July 26, post), but then the day after, that was better but my mood was really not good - full melt-down, worse than I’ve had in a while. 3: Then the next day, feeling a little better again, I had black bean soup from my freezer - salicylate load and oxalates. And yesterday was bad nausea and vomiting a couple times (July 28, post). Today hopefully I won’t make more food goofs and will manage to fit in more of my health aides that help me. (I list negatives and positives below.)
*Addition - I forgot to mention what I’ve been doing to help reduce the excess inflammation of my recent bad week. I have been taking Sweet Wormwood/Black Walnut extract daily while being so inflamed. It helps control the excess oxidative stress chemicals. I also took an extra Epsom salt bath. See: Targeting Ferroptosis Attenuates Inflammation, Fibrosis, and Mast Cell Activation in Chronic Prostatitis, (Lin, et al., 2022)
Ferroptosis – anemia of chronic infection/inflammation – severe fatigue.
The body will shift iron out of hemoglobin to protect it from suspected pathogens. In severe CoV, the normal response is overactive and can continue in LongCovid. Too little hemoglobin means too little oxygen, and extreme fatigue. Too much iron elsewhere can lead to cell damage from oxidative stress – ‘rust’ caused by electrically active iron. Thread about
ferroptosis (not available now), with (Varanasi, et al., 2017) and (Hulme, et al. 2020) and images from (Li, et al., 2020).
Excerpt from my home page (transcendingsquare.com)
Eating too much, carbohydrates and glutamate seasonings, can greatly increase the risk of ferroptosis – excess free iron and oxidative stress, and lead to increased blood sugar and insulin resistance. *It continues with an excerpt and more about high carbohydrate intake increasing risk of ferroptosis. (Hulme, et al. 2020; Varanasi, et al., 2017)
Mental health and inflammation - angry, crazy, or sick?
Is my mood meltdown a sign that I’m just angry and ‘toxic’ or that I’m just ‘crazy’ — or that I am on the autism spectrum — or that I have histamine excess issues at times which throw my mental health into a whirlwind of hyperexcitability? I think I am on the autism spectrum and that histamine excess is causal in mood melt-downs for autism and a few other conditions.
Is ‘schizophrenia’ a severe mood melt-down that just keeps continuing as long nutrients are out of balance and histamine and dopamine excess may be present?
Addition - not talking about the reality of mental illness is not helping the patients. Schizophrenics had a better quality of life and less social stigma 100 years ago then they do now. Psychiatric drugs are not helping underlying causal factors and do add to the problem and many types cause really unpleasant side effects. Basically, ‘mental health’ patients have been thrown away by society - left to the profit-oriented pharma industry and not cooperating can get a judge forcing the bad medications.
So, this is kind of a warning - severe inflammatory conditions can cause bizarre mental symptoms sometimes too - but adding inflammatory psych drugs will just make it worse for the person. They may need to focus on diet and lifestyle change instead. More importantly is the question of danger - the hyperexcitable mood is out-of-control, not really rational, tends towards paranoia, and could indeed be dangerous. I tend to be a self-injurer rather than violent against others, but the mental unwellness is scary and hard to control while it is happening. Akathisia medication reactions can lead to suicide/homicide and may involve Retinoid Toxicity due to liver injury. My symptoms got immensely worse only after withdrawal from olanzapine.
I have been cranky Tweeting these last few not-well days. I unfollowed someone because they made a slur like comment about new followers acting like schizophrenics.
Multifactorial problems - one person may have similar symptoms as another person but the causal factors may be a slightly different or very different combination of reasons. Anytime the medical industry tries to solve multifactorial problems with the old-school theory of one disease-one cause-one cure, then they and their patients are going to fail to restore health or understand the complexity of the issues.
Multifactorial problems has been a theme of mine since I started looking into risk factors for autism - there a ton, not just vaccines (which are a big factor). My own diet needs have reached a new level of complexity with the salicylate issue, and then is it vitamin A or solanine or both? (both), and sure don’t forget the oxalate issue. That was my issue yesterday. I tried some black bean soup that I had frozen and just should have skipped it as my digestive system was already kind of in recovery from the xanthum gum, and then the Peruvian ground cherries and generous broccoli serving - carotenoids and solanine led to a fibromyalgia like total body ache.
Overly restricting a diet isn’t good for variety of trace nutrients or for boredom. The question of what to eat with a sensitive gut also varies with how bad or good it is currently. I can eat black beans sometimes - but the frozen jar also had soe salicylate herbs and pomegranate peel.
People give me the impression that they want someone to tell them what to do or eat or which supplements to take - BUT - it is very individual what is going to work best for you, and most consistently. An overly confident coach or health counselor may seem like what you need, but then if it doesn’t work, are they just going to say you didn’t try hard enough, or need to stick with it longer, or would they say, Oh, maybe that isn’t what your body needs. Let’s move to a different strategy.
That kind of personalized attention takes time. Dmitry Katz made a lot of enemies online but he also made a strong base of supporters because he did answer questions in private text chats. He did figuratively hold hands and gave support while people were trying his high dose niacin protocol (at first). Once there is more popularity, that kind of personal attention is just not physically possible for larger numbers of people. Video courses and group question/answer sessions are a substitute for more individual coaching.
As I have written in a few posts - people in a severe state of inflammation and discomfort likely really need a live-in facility to help them recover enough and learn enough to then be able to go home and navigate through what is helping and what is not helping from their daily routine.
How to pay for that? Not with taxpayer funded money from a government who cares. We need to work on alternative solutions and try to fund them outside of the mainstream systems of finance. We have also seen money taken away by GoFundMe type sites against the Canadian truckers.
Digital currency is controllable. Health spending account dollars can only be spent on certain over the counter products and not for other things that you might prefer.
Eat at Your Own Risk - summary of things I find inflammatory to my gut or overall health (can I even remember them all - this is a self-quiz):
Histamine containing or promoting foods
Vitamin A and carotenoids
TRP channel activators
Solanine, glycoalkaloids - #1-4 all add to mast cell degranulation and histamine excess and can cause similar physical and mental symptoms.
Oxalates - low calcium and vitamin C may make this problem worse. If the needle like crystals are formed, then they cause needle like pain in the gut and bladder.
Salicylates (includes several red and yellow food dyes) - low glycine and elevated acidity of the urine would make this sensitivity worse.
Autoimmune molecular mimicry proteins (for me - albumin, animal or plant origin, and gluten) - the albumin issue caused non-healing skin rash for me, unlike other eczema, more open wound-like. Gluten is similar to thyroid tissue and can play a role in autoimmune hypo or hyperthyroidism.
More minor issue - betaine rich quinoa is a little unsettling for me as I don’t convert it to DMG well. Taking DMG more than I have would help with the salicylate sensitivity, so I have tried to be more consistent with that.
Strong emulsifiers like carrageenan, soy lecithen, or xanthum gum.
Aspartame, Neotame, glutamate seasonings = migraine inducing, hippocampus damaging.
Molds are also migraine producing but might fall under the histamine promoting category for me.
Glyphosate, pesticides, BHA/BHT preservatives, other additives that aren’t ideal - the glyphosate might cause digestive problems but the others might not cause obvious symptoms that help teach you to avoid them more carefully.
Things that I need to try to get plenty of, or I really do need a high dose supplement because of multiple gene differences:
Dimethylglycine, methionine, cannabinoids, phosphatidylcholine and/or choline, methyl folate and hydroxy or methyl B12, zinc and B6, topical magnesium.
High dose niacin protocol, and melatonin during the day, really seems to help me. I may be in the schizophrenia risk category with my various gene differences and the retinoid toxicity is also causal of schizophrenia like symptoms. That problem does seem to be multifactorial - many different causes that can produce a similar phenotype that is simply called ‘one thing’.
High dose niacin is acid producing and that has made my gut issues worse at times. (The nicotine lozenges did too. - I have quit those again.)
Taking baking soda in water seems to be the solution and I just may need to use a bit more than I had cautiously been using. You don’t want to go too far in the other direction on the pH scale either.
The LongCovid community has a low acid diet and test strip recommendation now that some people are finding success with. “Low Acid Diet” is not about the acidity level of the food, but about the acidity level that digestion of the food leaves behind in the body. Meat and dairy tend to be more acid producing than plant foods. Anything personally inflammatory however would also be more acid producing. Taking high dose niacin or vitamin C would increase acidity. Adequate magnesium would help tip back towards alkalinity.
This is a very good article on ‘low acid diet’ by a kidney dietitian - however, oxalates in the recommended plant foods are not mentioned, and oxalates can also be a risk to kidney health and a cause of kidney and bladder pain. People may need baby steps towards change. Throwing the entire list of possible problems at them at one time may be too overwhelming. What Is PRAL & How Does It Affect Kidneys? - The Kidney Dietitian
Methylation cycle disruption is a direct cause of increased lactic acid production within the body, no matter what your diet includes. *Diet can also cause methylation cycle disruption - salicylate excess does that as an example. Saturated fat intake above 10% of total calories is a signal to switch to glycolysis and stop using the Citric Acid Cycle. Lactic acid excess may be seen in stressful trauma or chronic conditions. (Li, X., et al., 2022)
“Nevertheless, overwhelming evidence suggests the occurrence of the Warburg effect in many nontumor cells and in a wide range of noncancerous diseases, such as pulmonary hypertension, pulmonary fibrosis, heart failure, atherosclerosis, and polycystic kidney disease14,15. Compelling evidence indicates how aerobic glycolysis produces lactate under stressful conditions, such as trauma, infection, myocardial infarction, and heart failure. Lactate is always an inevitable end product of glycolysis, regardless of oxygen availability.” (Li, X., et al., 2022)
My gene differences add up to me being more acid producing anytime I exert myself much. I tried to get a part-time job as an aerobics instructor in my past but wasn’t hired because my face turned too red not because my dance routine was not good. I was told I needed to make it look more effortless, not like I had run a marathon (roughly).
Not methylating well means that I would produce more lactic acid/lactate from the glycolysis of energy, since I wouldn’t be using the Citric Acid Cycle as well as normal. The excess lactate can lead to excess acidity in the body but may also become modified in a way that promotes cancerous changes. See: Lactate metabolism in human health and disease | Signal Transduction and Targeted Therapy, (Li, X., et al., 2022)
Taking my methyl supplements, choline, DMG and methionine, is helping protect my cells from epigenetic changes that can be cancer promoting too.
*I was given a Bipolar Type 1 diagnosis but the diagnostic process seems a farce to me and I think I was closer to ‘schizophrenia’ than I realized while in histamine excess daily for many years without knowing what the underlying issues were.
Disclaimer: This information is being provided for educational purposes within the guidelines of Fair Use and is not intended to provide individual health guidance.
(Hulme, et al. 2020) Hulme KD, Yan L, Marshall RJ, Bloxham CJ, Upton KR, Hasnain SZ, Bielefeldt-Ohmann H, Loh Z, Ronacher K, Chew KY, Gallo LA, Short KR. High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier. Elife. 2020 Jul 22;9:e56907. doi: 10.7554/eLife.56907. PMID: 32697191; PMCID: PMC7392605. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392605/
Li, X., Yang, Y., Zhang, B. et al. Lactate metabolism in human health and disease. Sig Transduct Target Ther 7, 305 (2022). https://doi.org/10.1038/s41392-022-01151-3Lactate metabolism in human health and disease | Signal Transduction and Targeted Therapy (nature.com)
(Li, J., et al., 2020) Li, J., Cao, F., Yin, Hl. et al. Ferroptosis: past, present and future. Cell Death Dis 11, 88 (2020). https://doi.org/10.1038/s41419-020-2298-2 https://www.nature.com/articles/s41419-020-2298-2
(Li, X., et al., 2022) Li, X., Yang, Y., Zhang, B. et al. Lactate metabolism in human health and disease. Sig Transduct Target Ther 7, 305 (2022). https://doi.org/10.1038/s41392-022-01151-3 Lactate metabolism in human health and disease | Signal Transduction and Targeted Therapy (https://www.nature.com/articles/s41392-022-01151-3)
(Lin, et al., 2022) Dongxu Lin, Mengyang Zhang, Changcheng Luo, Pengyu Wei, Kai Cui, Zhong Chen, Targeting Ferroptosis Attenuates Inflammation, Fibrosis, and Mast Cell Activation in Chronic Prostatitis, J of Immunology Research, vol. 2022, Article ID 6833867, 12 pages, 2022. https://doi.org/10.1155/2022/6833867 https://www.hindawi.com/journals/jir/2022/6833867/
(Varanasi, et al., 2017) Varanasi SK, Donohoe D, Jaggi U, Rouse BT. Manipulating Glucose Metabolism during Different Stages of Viral Pathogenesis Can Have either Detrimental or Beneficial Effects. J Immunol. 2017 Sep 1;199(5):1748-1761. doi: 10.4049/jimmunol.1700472. Epub 2017 Aug 2. PMID: 28768727; PMCID: PMC5584583. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584583/
What Is PRAL & How Does It Affect Kidneys? - The Kidney Dietitian
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