Anti-malarial herbs, Cox-2 inhibition leading to folate and methylation cycle inhibition - that's not good for healthy cells, but useful against cancer cells.
Anti-malarial herbs, Cox-2 inhibition leading to folate and methylation cycle inhibition - that's not good for healthy cells, but useful against cancer cells.
This is another reminder that some can be good, but too much of many things can become a negative. Plant phytonutrients often are intended to ward off predator insects or fight microbial pathogens.
JD - "The mechanism of action of Artemisia absinthe against malaria IS THOUGHT TO involve the inhibition of the DHFR enzyme, which is essential for the survival of the malaria parasite."
"Context - I am still not seeing where the AI got the malaria mechanism of action information."
DHFR inhibitors: pyrimethamine and proguanil as antimalarial drugs (hello); trimethoprim, an antibacterial drug commonly used in association with sulfonamides, like sulfamethoxazole; and methotrexate, the first-in-class anti-cancer agent acting via DHFR inhibition.
It is likely that the artemisinin radicals generated by heme activation may alkylate sulfur ligands and prosthetic heme in functional proteins or enzymes, leading to irreversible inactivation of these proteins.
AI = oy vey...."is thought to" or "it is likely" means the same answer to the same question that remains unanswered for the the last four millenia Agent Scully.
JD - "The mechanism of action of Artemisia absinthe against malaria IS THOUGHT TO involve the inhibition of the DHFR enzyme, which is essential for the survival of the malaria parasite."
"Context - I am still not seeing where the AI got the malaria mechanism of action information."
DHFR inhibitors: pyrimethamine and proguanil as antimalarial drugs (hello); trimethoprim, an antibacterial drug commonly used in association with sulfonamides, like sulfamethoxazole; and methotrexate, the first-in-class anti-cancer agent acting via DHFR inhibition.
It is likely that the artemisinin radicals generated by heme activation may alkylate sulfur ligands and prosthetic heme in functional proteins or enzymes, leading to irreversible inactivation of these proteins.
AI = oy vey...."is thought to" or "it is likely" means the same answer to the same question that remains unanswered for the the last four millenia Agent Scully.