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Dani Richards's avatar

I just saw this. I wanted to say that I appreciate you. I am an herbalist (North American, primarily) and I understand where you are coming from, even if it is a different axis or focus from mine -- it dovetails nicely. I hope you will keep writing, just as you have been; do not self-censor. Just put it out there and your audience will find you. Not everyone has ears to hear, and I suggest that you do not change a thing.

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Sounds Like Nonsense's avatar

FRANK

Aʟᴢʜᴇɪᴍᴇʀ Exᴘᴇʀᴛ & Bʀᴀɪɴ Mɪᴄʀᴏʙɪᴏᴍᴇ Exᴘᴇʀᴛ

Frank Bernier, PhD, MSc, CIP

https://www.linkedin.com/posts/francois-bernier-phd_alzheimers-alzheimer-neuroscience-activity-7065154571030974464-QUO4

The Gut Microbiota-Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool

This immensely important paper presents compelling data on the connection between the gut microbiota and Alzheimer's disease (AD), a type of dementia. The study conducted on elderly adults and Wistar rats demonstrates an intriguing link between certain proteins and bacteria in the gut, and cognitive impairment and dementia.

The key research findings provide a plausible mechanistic link between gut microbiota alterations and Alzheimer's disease.

With aging, the study found significant increases in tau protein, β-amyloid, and LPS (lipopolysaccharide) - all known contributors to the onset and progression of Alzheimer's disease.

Notably, these increases were found to be associated with an increased abundance of E. coli that produce the amyloid protein curli. Curli, as the study suggests, might promote the aggregation of amyloid proteins, a characteristic feature of Alzheimer's disease.

Furthermore, the study revealed an interesting finding from preclinical experiments on Wistar rats. The rats showed an increase in the abundance of curli protein in the brain with aging, implying that this protein, which is linked with certain gut bacteria, could make its way to the brain and potentially contribute to neurodegenerative processes.

These findings represent a significant step towards understanding the role of the gut microbiota-brain axis in the development of Alzheimer's disease.

The observation that cognitive impairment and dementia could be partially attributed to gut microbiota alterations provides a promising new direction for further research and therapeutic strategies.

The Gut Microbiota-Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool

https://pubmed.ncbi.nlm.nih.gov/36839291/

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