WordPress comment, again; TRPC GP109
Kidney podocytes too. GP109 has a protective role in the kidney. Is that relevant to histamine excess nociceptive pain? Maybe
Kidney injury is a risk of histamine excess and Retinoid Toxicity. Thinking cap. 🤔
Addition - after sleep: Take home point I didn't add in my half-asleep state: Drink more coffee for the niacin and because the polyphenols in coffee promotes calcium excretion - if hyperinflammation is a problem. But my gut can’t take coffee anymore. Making the sub-point that pomegranate peel is likely protective against kidney injury for similar reasons - bitter taste receptors help regulate some types of TRP calcium channels similarly to the butyrate/niacin GP109 receptor. GP-coupled receptors have exterior and interior sections - a message on the outside can cause an action to happen within the cell.
I am procrastinating today from the research article, got distracted need to return. So I did a search for GP109 TRPC to see what I might find.
Random stuff. Search terms that are too vague get wide variety in the results.
I also got my own site in the results, always fun, with the draft of my paper.
And the comment about WordPress, or having a website, is, …but I don't get my SubStack posts in search results. I wonder what the web crawler difference is.
The blurb about kidney podocytes is a clue about kidney injury and why bitter tastes may help, or niacin and butyrate. Both use GP-coupled receptors which may play a regulatory role over some TRP channels. That may explain why bitter tastes can be anti-inflammatory and healing for the kidney or elsewhere. Pomegranate peel is very bitter and healing to the kidneys and other organs.
Regulation - inhibition - an Off switch for damaging calcium. Some receptor modulators allow function without calcium flow - curcumin at the Vitamin D receptors is an example I think. That would be helpful to those with too mych calcium flow.
I think the connection that GP-coupled receptors can work in concert with TRP channels is important. “Bitters” is medicinal because it is bitter, the bitter GP-coupled taste receptors may also inhibit TRP channels of some types, preventing intracellular calcium entry which increases inflammationand risk of cell death.
Social media platforms splinter us into micro communities.
Site traffic over time and active posting with plenty of links helps SEO, and unique key words. I must say I like having my ~notebook searchable online. Handy for me and may lead others to new ideas.
This may be pre-sleep posting.
Water! Balanced electrolytes! That is what our kidneys like. Maybe butyrate or niacin too. And maybe bitter tastes too.
TRP channels are complex and still in the early days of research. Nobel Prize winner topic recently.
More research is needed.
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