Weight loss and our internal light network; Melanin & Collagen are semi-conductors - Kruse/Huberman interviews.
Weight loss in a nutshell - more sunlight, avoid blue light screen time, especially in the evening hours. Have blackout dark for sleep.
Dr. Jack Kruse is a neurosurgeon turned health maverick. The bright lights and EMF intense environment of neurosurgery had left him unwell and weighing over 300 pounds. A PhD friend said she could help if he read what she sent him in the order she recommended. That set him on a two year learning journey that led back in time to the KT event that led to dinosaurs dying off and then to the sunny beaches of Costa Rica near the Equator. What he learned did help him lose weight on the sunny beaches and revolutionized his thinking about medical research and health care.
Leptin is part of the discussion in a video shared by Timothy Winey. The video is a talk by Dr. Jack Kruse being interviewed by, or meeting with Andrew Huberman and the host is Rick Rubin, on his podcast Tetragrammaton. Rick is a famous musician and was a patient and success story for Dr. Kruse’s health recommendations, (~4 hours). https://podcastnotes.org/tetragrammaton-rick-rubin/dr-jack-kruse-and-andrew-huberman-ph-d-tetragrammaton-with-rick-rubin/ *The podcast notes seem to be AI generated and are not 100% accurate but do give an overview of the 4 hours and can help find sections of interest for relistening or more concise listening.
We make our own internal light. That is part of the big news Jack Kruse is trying to tell us. Part two is here, ~ 2+ hours (Youtube). Modern life disrupts our ability to make internal light and then we think and function at a slower pace than during optimal health which clips along at a quantum pace. *The part two video is embedded later in the this post.
What I will call part 3 is a brief, one hour, episode of Tetragrammaton with Rick Rubin, a journalist Bill Griffon (?) and Jack Kruse.
Sunshine and cold can help us lose weight, modern blue light is fattening and causes hypoxia - lack of oxygen.
In a nutshell - sunshine helps us to lose weight and to create more of our own internal light/energy while the intense blue light of modern life screens and fluorescent and LED lights is likely making us oxygen deficient - hypoxic, and leading to weight gain. News to Use - too much computer time is inflammatory and fattening. The dopamine stimulation may also be addictive and lead to wanting to stay on the stimulating screen, and elevated dopamine can also stimulate overeating.
If you don’t have a beach chair on a beach near the Equator, then our other option besides sunshine for helping promote weight loss is still to get outside in the morning even if it is cold. Get a few goose bumps, shiver a little. When our brown fat burns energy, it produces heat for us internally. And that is similar to what the high dose niacin protocol’s “niacin flush” is doing, but all at once, for a 30-45 minutes. Mitochondria can ‘uncouple’ energy production from making ATP and switch over to producing warmth instead. Niacin or butyrate can signal for that switch to happen by activating the GP109 receptor. *Dr. Kruse briefly mentions cold, mitochondrial uncoupling and brown fat as another way to produce heat and help with weight loss. He didn’t get into the details about niacin/butyrate and the GP109 receptor.
“The epic battle for the cell is to have the regularly expected circadian cycles found in our environment and ”yoke” those signals to its metabolic cycle and to its growth cycle. Most people know that the suprachiasmatic nucleus (SCN) in the brain is where the circadian pacemaker lies in humans. It monitors this dance between darkness and light, and the seasonal cold and hot temperatures in our environment to help control and monitor our own growth and development. Evolution apparently agreed to use these signals in all living things because this is what it uses for all life on earth today. What most people do not know is how leptin plays a massive role in regulating it. Many people and physicians think it plays a small role. Recent research has revealed that leptin can induce expression of a neuropeptide called vasoactive intestinal peptide (VIP) through the VIP cytokine response element. This is an epigenetic modification from our environment directly signaling the master hormone in our body. So what does VIP actually do?
VIP actually is what sets the circadian pacemaker to the light cycles. This enables Leptin to then yoke metabolism and sleep directly to the light and dark cycles of our day. So what happens when light levels are not strong during seasons? When temperature becomes the dominant environmental trigger and not light cycles, leptin induces endothelial nitric oxide synthetase (eNOS) that shuts down the photic effects of VIP on the SCN. This means that leptin uncouples the SCN to be unable use light as the main stimulus to yoke circadian cycles. Once temperature becomes the dominant method of entrainment used to yoke the circadian rhythms to leptin, some very unique things happen to our biochemistry that normally do not occur in other environments. These are ancient epigenetic programs that are hardwired into the DNA of every descendant of any eutherian mammal on this planet. We are descended from these animals as well.” […]
“In fact, cold environmental conditions favor the formation of optimal T3 and T4 levels. It also activates the leptin-melanocortical pathway.” (jackkruse.com)
Dr. Kruse’s Leptin resistance protocol seems based on Paleo diets and carbohydrate restriction and use of specific animal fats or coconut oil with avoidance of seed oils. He recommends not calorie counting, which I agree with, but also doesn’t discuss total fat or saturated fat effects on mitochondrial methylation. Too excess of a ratio of fat calories in the diet can lead to gut microbiome dysbiosis and mitochondrial switch to anaerobic energy production which is inefficient and produces more negative waste chemicals that are acidifying. That can be cancer promoting instead of healthy. (Leptin Reset Easy Start Guide, jackkruse.com)
Our internal light production can get hot, but it is microscopic generally.
We make our own internal light - and it can be a more powerful reaction - a hotter heat than the sun, according to Dr. Kruse. I will need more study to cite that. That idea however could help explain the real world oddity of people self-combusting. Odd but true, a few people have died from bursting into flames. If something went wrong with our internal energy production and a ‘niacin flush’ kept getting hotter and hotter instead of dissipating after 45 minutes - then that would be bad - maybe even combustible. *speculation.
Medical research needs to have controls done in darkness or red light.
Dr. Kruse’s revolutionary realization about medical research, including neurology, is that all experiments may be flawed in that they were conducted under the bright blue light of laboratory or hospital settings. Those little cells in a petri dish were never intended to be so exposed to bright light. What is the bright light doing to their function? . . . We don’t know because no control petri dish was being run through the experiment in dark settings or red light settings.
[*Disclosure - I grew up with a dad who did Black and White film developing in our basement, so I learned early in life about red light dark rooms and to not open the basement door when he was developing film. he did teach me how as a teen and I took a college class on the topic too. Digital film put that industry into the terminal ward.]
Modern work environments can be very sickening
Dr. Kruse’s other big take-home-point - our work environments or home, can be making us sick. And that having a confident, arrogance about ‘knowing’ something may be our Achilles Heel - we can be wrong.
Airplanes have toxic air, especially during take-offs and landings. It can make workers sick. Nature’s medicine cabinet can be protective. Airline air quality is the topic of an interview by Lies are Unbekoming with former airline stewardess Bearnairdine Beaumont. (Substack) A big point she makes is that the risks have been known and studied for 60 years, yet the industry doesn’t really have a better solution so it is hushed up. Good air filter maintenance would help but she recommends taking an emergency personal air filtration mask for your own safety. The chemical exposure can lead to long term inflammation and disabling physical and mental symptoms.
The dental industry is not talking about the risk of mercury fillings to dental staff or patients for similar reasons - too much liability, too many dentists would be at risk legally if the true medical risk was openly revealed.
Getting into the details of the Kruse/Huberman videos is a book length project. Dr. Kruse covered a lot of territory in the 6 hours of video discussion with Andrew Huberman.
The rest of this post wanders a bit, discussing a few things from the Kruse/Huberman videos.
This previous post was background material I already had gathered about leptin and weight while writing my pomegranate for histamine excess paper. This overlaps with the Melanocortin pathway and POMC info included later in this post. Leptin, POMC, Iodine and Pomegranate, (Substack)
This older post, Oct 2022, is also on the topic of alpha melanocyte stimulating hormone* and appetite/weight control. α-MSH, regulator of appetite and weight and our bone matrix. (& we need Zinc too!), Production of α-MSH is promoted by leptin and α-MSH can inhibit leptin production, suggesting a feedback loop during normal function. Obesity often has elevated leptin & lack of receptors. (Substack)
*More recent posts on beta-ionone include the fact that it helps promote melanin by promoting α-MSH. Violets - revered by kings for the healing essential oil.
Beta-ionone is the interesting and healing aromatic chemical with the fragrance of violets - also in Osmanthus flowers and essential oil, iris, petunias and in small amounts in many fruits & veggies. (Substack)
Proteins act as semi-conductors
Jack Kruse said that proteins are semi-conductors of electric flow in our body, specifically mentioning collagen and melanin.
What is a Semi-conductor?
“It controls and manages the flow of electric current in electronic equipment and devices. As a result, it is a popular component of electronic chips made for computing components and a variety of electronic devices, including solid-state storage.” (techtarget.com)
The correct essential oil, transmits frequencies that can help recalibrate our internal organ frequencies when we are out of sync by restoring healthy vibrations; based on information in David Stewart’s book The Chemistry of Essential Oils Made Simple. (vibrantblueoils.com)
If it seems implausible that proteins are semiconductors or can be, consider that synthetic proteins can be used to make quantum for semiconductors. De novo = not found in nature. Synthetic or not natural amino acids were used to make not natural proteins. See: ‘A de novo protein catalyzes the synthesis of semiconductor quantum dots’. (Spangler, et al., 2022)
Leptin and collagen seem to be part of our semiconductor system and melanin.
We are energy beings with a greater flow at our hands and feet and heart and the skull seems to reduce the energy field that might be happening within the brain.
An electrical network can have interconnected nodes that add up to a larger capacity of function. Within our body we would have many miniature semiconductors throughout our bodies. The bone matrix and our teeth are part of the energy system.
If you widen your perspective - humans across the world are all energy beings with overlapping energy fields - we are also like nodes within a larger energy network -a nd we can be sharing positive organized energy waves, or chaotic unsynchronized energy waves.
The universe, and the ‘Oneness’ of the Tao are not empty, there is aether flow. Spiral nebulae and spiral shaped DNA are not coincidental, they are following the spiraling flow of aether.
Leptin Melanocortin pathway and appetite control
Above graphic- Leptin and Obesity, https://www.dropbox.com/scl/fi/ijq7ymkqlibr5dua0z17s/fendo-12-585887.pdf?rlkey=zb8qurlvpv6ssu9dmyzsc161q&dl=0
Leptin melanocortin pathway is discussed by Jack Kruse in a video with Andrew Huberman and Rick Rubin, see last post for some background info about leptin. The video below is part two of the interview. He has a drill sergeant style of education. Jack Kruse was on a podcast with The Power Couple, (Substack), and spoke about the need for that type of direct command style of education or coaching for people who are low in dopamine. They might not be able to motivate themselves to change with out someone kicking a little proverbial butt.
Example of circadian cycle epigenetic changes - in a hamster species
Gene expression was studied in a species of hamster that has a dormancy-like period called torpor that occurs daily instead of seasonally. Genes encoding for five different collagens were up-regulated during the entrance into torpor and Dnah2 and Myo15a. At all other times, those two genes and Vwf were down-regulated. Within the hypothalamus, during entrance into the torpor phase, 181 genes were found to be up regulated and 103 genes were down regulated. (Cubuk, 2017)
This seems related to the research that was being described by Jack Kruse. Investigation of hypothalamic regulatory mechanisms during spontaneous daily torpor and fasting-induced torpor in the Djungarian hamster (Phodopus sungorus), a dissertation submitted by Ceyda Cubuk, 2017, Hamburg, (Melanopsin-and-Leptin-Dissertation) Quote below.
Our habits, and light environment, may be making our pets overweight too. (Wallis and Raffan, 2020)
The following excerpt provides a lot of info about leptin, circadian cycle effects and how a high fat diet may lead to over-eating. I broke it up into shorter paragraphs.
“Circadian rhythm alterations lead to increased glucose and insulin levels as well as increased arterial pressure, decreased leptin levels, sleep deficiency, and altered cortisol secretion rhythm [35].
Leptin signaling, which modulates satiety, exhibits circadian variation and may link clock gene fluctuations with metabolic diseases such as diabetes and obesity [35].
Indeed, unusual food intake timing has been linked to altered satiety signals and reduced serum leptin levels [25,36,37]. This reduction in leptin levels leads to increased appetite while reducing energy expenditure and therefore promotes the development of obesity and other metabolic disorders [35].
Another factor that may explain the influence of circadian clocks on metabolism modulation is the effects on thermogenesis and energy expenditure [25].
Thus, thermogenesis is induced by meal intake and follows a circadian rhythm, being highest in the morning, followed by the afternoon and night [25].
Hence, this may explain why skipping breakfast is linked to increased body weight.
Recently, it has been shown that this increased diet-induced thermogenesis in the morning may be due to the circadian rhythmicity of circulating norepinephrine and epinephrine, with increased values in the morning; these compounds are known to influence food intake modulation [38,39].
Moreover, in a study of healthy individuals, the same meal consumed in the evening resulted in a lower resting metabolic rate (RMR) and increased glycemic/insulinemic response, suggesting circadian variations in energy expenditure and metabolic pattern [40].
The hunger hormone ghrelin has also shown circadian oscillation, with the lowest levels in the morning, and modulates energy expenditure and thermogenesis via the suppression of brown fat thermogenesis [38].”
[…]
“Nutrients and food factors can also modulate cellular circadian clocks or clock systems throughout the body. Thus, high-fat diet (HFD) consumption leads to increased food ingestion during the light period in mice, which may contribute to alterations in body weight regulation and to altered circadian patterns of circulating metabolic markers such as leptin and insulin, clock-regulating nuclear factors RORα and PPARα, hypothalamic neuropeptides AgRP and NPY, and factors involved in lipid metabolism [45]. In addition, HFD consumption has been reported to alter AMPK kinase signaling, which is activated in situations of energy shortage, leading to aberrant clock gene expression in comparison with the expression associated with a normal diet [46]. This HFD-mediated AMPK signaling alteration was improved in mice with time-restricted feeding despite equivalent caloric consumption as those with ad libitum access, leading to protection against obesity, hyperinsulinemia, hepatic steatosis, and inflammation [47,48]. In addition, HFD consumption in mice under constant darkness also alters the circadian locomotive rhythms, increasing their locomotive activity [45].”
Chrononutrition and Polyphenols: Roles and Diseases, (Arola-Arnal, et al., 2019)
~~
Regarding Cross Domain Bacteria / Hydrogel biotech -
According to Carnicom Institute it may be best to break it up early - preventing the clots is more likely than hoping to dissolve the rubbery clots later.
There are four regions of marked change in the absorbance of ultraviolet energy that demonstrate enzymatic disruption to the CDB. These are marked on the plot, and include variation in the locations or regions :
1. 210-220 nm.
2. 236 nm.
3. 260 nm.
4. 285-400 nm.
Carnicom Institute, (Substack)
That sounds a lot like Fritz Popp. He found that substances with anticancer potential all had the same light frequency - similar chemical shape didn’t matter as much as the light frequency affected by the chemical, (roughly, I don’t know the details).
Georges Lakhovsky (1870-1942), Good Vibrations
Russian scientist and inventor Georges Lakhovsky stated that all cells of living beings emit and receive radiation and that altering their natural vibration causes them to lose vitality and malfunction. He also said that all cells are in resonance with two types of radiation: those coming from the interior of the Earth (telluric) and those coming from space (cosmic), including solar radiation. So as long as they vibrate harmonically, resonating with them you will be healthy. Lakhovsky has been criticized by physicists who are ignorant of biology and by biologists ignorant of physics. Lakhovsky was the first experimenter to make use of high-frequency electromagnetic waves in the domain of biology. According to Lakhovsky the nucleus of a living cell may be compared to an electrical oscillating circuit. Health in this view is equivalent to the oscillatory equilibrium of living cells whereas disease is characterized by oscillatory disequilibrium. These concepts go hand in hand with Popp's biophotons (Popp, 2003). Biophotons are bits of light energy, that are generated spontaneously by most living cells. Popp believes that biophotons are created in the DNA that resides in the mitochondria in your cells. They are created in the part of the DNA molecule that is not used for genetic coding (introns).
Fritz-Albert Popp (1938 -2018)
German researcher in biophysics, particularly in the study of biophotons. He studied the biophotonic nature of our underlying physiology and how our bodies truly function. Popp found that the spectrum of colorful electromagnetic light energies (in the form of biophotons) forms an intricate, highly organized system of communication between our body's cells and ultimately, is responsible for the regulation of all of our body's physiological processes. In other words, he found that every human body is essentially a being of light. He explained that a quanta of light can initiate, or arrest, cascade reactions in the cells, and that genetic cellular damage can be virtually repaired by beams of light and that the function of our entire metabolism is dependent on light (Popp, 2008).
Excerpt from this repost from Green Med Info - it is a long reference article: Quantum Orthomolecular Medicine: The Bio-Orthophotonic Concept of Healing Energy, (Substack)
Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of Fair Use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
Reference List
(Arola-Arnal, et al., 2019) Arola-Arnal A, Cruz-Carrión Á, Torres-Fuentes C, Ávila-Román J, Aragonès G, Mulero M, Bravo FI, Muguerza B, Arola L, Suárez M. Chrononutrition and Polyphenols: Roles and Diseases. Nutrients. 2019 Oct 30;11(11):2602. doi: 10.3390/nu11112602. PMID: 31671606; PMCID: PMC6893786. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893786/
(Pivovarova, et al., 2015) Pivovarova O, Jürchott K, Rudovich N, Hornemann S, Ye L, Möckel S, Murahovschi V, Kessler K, Seltmann AC, Maser-Gluth C, Mazuch J, Kruse M, Busjahn A, Kramer A, Pfeiffer AF. Changes of Dietary Fat and Carbohydrate Content Alter Central and Peripheral Clock in Humans. J Clin Endocrinol Metab. 2015 Jun;100(6):2291-302. doi: 10.1210/jc.2014-3868. Epub 2015 Mar 30. PMID: 25822100. https://pubmed.ncbi.nlm.nih.gov/25822100/
“We examined the effects of switching from a high-carbohydrate, low-fat diet to a low-carbohydrate, high fat (LC/HFD) isocaloric diet on the central and peripheral circadian clocks in humans.
Design: Diurnal patterns of salivary cortisol and gene expression were analyzed in blood monocytes of 29 nonobese healthy subjects before and 1 and 6 weeks after the dietary switch. For this, we established a method of rhythm prediction by 3-time point data.
Results: The centrally driven cortisol rhythm showed a phase delay 1 and 6 weeks after the dietary switch to a LC/HFD as well as an amplitude increase. The dietary switch altered diurnal oscillations of core clock genes (PER1, PER2, PER3, and TEF) and inflammatory genes (CD14, CD180, NFKBIA, and IL1B). The LC/HFD also affected the expression of nonoscillating genes contributing to energy metabolism (SIRT1) and fat metabolism (ACOX3 and IDH3A). Expression of clock genes but not of salivary cortisol in monocytes tightly correlated with levels of blood lipids and with expression of metabolic and inflammatory genes.” (Pivovarova, et al., 2015)
(Spangler, et al., 2022) Spangler LC, Yao Y, Cheng G, Yao N, Chari SL, Scholes GD, Hecht MH. A de novo protein catalyzes the synthesis of semiconductor quantum dots. Proc Natl Acad Sci U S A. 2022 Dec 20;119(51):e2204050119. doi: 10.1073/pnas.2204050119. Epub 2022 Dec 12. PMID: 36508665; PMCID: PMC9907092. https://pubmed.ncbi.nlm.nih.gov/36508665/
(Wallis and Raffan, 2020) Wallis, Natalie & Raffan, Eleanor. (2020). The Genetic Basis of Obesity and Related Metabolic Diseases in Humans and Companion Animals. Genes. 11. 1378. 10.3390/genes11111378. https://www.researchgate.net/publication/347117241_The_Genetic_Basis_of_Obesity_and_Related_Metabolic_Diseases_in_Humans_and_Companion_Animals