An ebook was shared with me in the comments, The Power of the Powerless, by Vaclav Havel, 1978, Thanks! I haven’t read all of it yet, but it looks good.
“Ideology, in creating a bridge of excuses between the system and the individual, spans the abyss between the sins of the system and the aimd of life. It pretends that the requirements of the system drive from the requirements of life. It is a world of appearances trying to pass for reality.” (Dropbox pdf *sync.com is a little slower for me to use (so far). Dropbox works on my phone and laptop.)
Adrenochrome & Schizophrenia, a revisit with some edits and additions.
I have a two post series on the topic of adrenochrome and schizophrenia which I have meant to get back to. The posts have some other narrative, so I am excerpting the adrenochrome part of the story here. *So, you don’t need to visit those posts.
Adrenochrome & Schizophrenia; and the AHA! Acurate Health Award for accurate health research. *My made-up award. (Substack)
“Ehden shared a chapter from a book (on Telegram) that is about the chemistry of adrenochrome and the health of patients with schizophrenia.
Chapter III. Adrenochrome and Some of Its Derivatives, The Hallucinogens, by A. Hoffer and H. Osmond, 1967, Academic Press, (pdf in my Dropbox)
*The ‘chapter’ is 181 pages long. My notes follow.”
Adrenochrome & Schizophrenia-like thinking, Part 2; (Substack)
The gist seems to be that people with schizophrenia are not clearing adrenalin/adrenochrome adequately and accumulation of adrenochrome causes hallucinations and disordered thinking. Alternate breakdown of adrenochrome causes a brown colored version of melanin to form (rather than black which forms from dopachrome) and people with schizophrenia tend to get brown hair earlier as children (rather than stay blonde or have black hair) and to not go white-haired as soon as an older adult. […]
This passage explains why people with schizophrenia likely need the 3000 mg of niacin/nicotinic acid each day:
“Ehrensvard et al. (1960) and Heath and Leach (1962) found that schizophrenic serum oxidized 3-hydroxyanthranilic acid enzymatically more slowly than did normal serum. This suggests schizophrenic serum contains less of the enzyme which converts 3-hydroxyanthranilic acid into nicotinic acid. The result would be an increase in 3-hydroxyanthranilic acid, an increase in 3-hydroxykynurenine, an increase in ommochromes formation, and a deficiency of nicotinic acid.” (page 287, Chapter III. Adrenochrome and Some of Its Derivatives, The Hallucinogens, by A. Hoffer and H. Osmond, 1967, Academic Press, (pdf in my Dropbox)
Lack of glutathione or cysteine or glycine would be likely to increase adrenochrome accumulation too. And excess of it depletes glycine and glutathione. That helps explain my risk in part - genetically low in dimethylglycine, DMG.
I have run into too low serotonin/niacin symptoms on the 50 mg/day diluted in several beverage servings (I have lots left as a bulk powder). Taking it all at once activates the inflammation reducing flush response more. I have been trying to continue to stay lower acidity due to the uric acid risk, but I have moved back up to 50 mg twice a day with at least one of the servings taken all at once.
Excess adrenochrome would then lead to reduced GABA which is calming and that would just add to the mental over-activity.
Retaining phosphorus, or losing too much - phosphate imbalance also seems involved in schizophrenia genetics - that might go hand in hand with fibromyalgia seeming to have odd phosphorus issues too.
Adrenochrome can reduce sensitivity to histamine and schizophrenia patients have ben found to have higher levels of histamine than average while not having as quick of a reddening reaction on the skin when scratched.
High pressure oxygen situations replicate the poor judgement or distorted thinking of schizophrenia.
Adrenochrome excess may cause schizophrenics to get colder in cold temperatures more than average. Adrenochrome excess may add to anti-thyroid problems. Schizophrenia patients seemed to tolerate larger and need larger than average doses of thyroid treatment (pre days of Synthroid - something like porcine thyroid extract was used). Or 200 micrograms of iodine helped patients with schizophrenia. Thyroid function and hormone levels were normal. The problem was found in peripheral use of thyroid hormone. Higher dosing seems to help bypass anti-thyroid effects caused by excess adrenochrome within the body tissues.
Adrenochrome is a topic I looked into at the request of someone, and I saw that there had been a bunch of research on it in the 50s and then not much. It caused ‘schizophrenia-like symptoms’ but showed that it might have anti-aging effects due to effects on mitochondrial health. The following passage shows adrenochrome is involved with uncoupling of mitochondrial ATP production similar to what high dose niacin can do with activation of the GP109a receptor.
“Rawson et al. (1957) stated that adrenochrome prevented metamorphosis of tadpoles. This is a property shared with other indoles and provides direct evidence that thyroid hormone and adrenochrome are antagonists.
It is curious that both thyroxine and adrenochrome are uncouplers of oxidative phosphorylation. J. Bain (1957) reported that a subeffective dose of thyroxin (5 X 10—5 M) and a subeffective dose of adrenochrome ( 2 X 10—5 M) added together produced 50% uncoupling of oxidative phosphorylation.” (page 303) Chapter III. Adrenochrome and Some of Its Derivatives, The Hallucinogens, by A. Hoffer and H. Osmond, 1967, Academic Press, (pdf in my Dropbox)
Interfering with tadpole metamorphosis suggests to me that excess adrenochrome negatively affects quantum energy flow and structuring of cell water - disrupting the holographic like formation of a new shape for the developing frog.
Fetal development is or involves ‘quantum biology,’ whatever that term means these days.
» Adrenochrome excess seems to protect against diabetes that is due to lack of insulin, by inhibiting breakdown of insulin by insulinase.
Regarding disrupted phosphorus metabolism - it is the uncoupling of ATP production:
“There is a good deal of data which show that schizophrenic erythrocytes do not metabolize glucose in the same way as normal erythrocytes. Boszormenyi-Nagy and Gerty (1955) found that insulin pretreatment of normal erythrocytes inhibited the accumulation of adenosine triphosphate (ATP) by hemolysates incubated with pyruvate and hexose diphosphate. This inhibition of ATP buildup was not observed with schizophrenic erythrocytes. Since adrenochrome is a very powerful inhibitor of ATPase while adrenaline alone has no effect it is likely this differential effect of erythrocytes is due to an accumulation of oxidized adienaline derivatives. That is with normal erythrocytes insulin would increase utilization of ATP but with ATPase inhibited by adrenochrome this could not occur in schizophrenic cells. Orstrum and Skaug (1950) also found a decreased turnover of ATP in schizophrenics. Randall (1946) and Meyerhoff, and Randall (1948) found that adrenochrome inhibited hexokinase and phosphohexokinase. A concentration of 4 X 10 — 5 M inhibited these enzymes 50% . The degree of inhibition was inversely related to the amount of ATP present.
These earlier findings have some relevance to recent work on toxic protein fractions in schizophrenics. Frohman et al. (1960) found that schizophrenic red cells under basal conditions took up much more labeled 32 P than did normal subjects. There was an inability to utilize ATP.” (page 307) Chapter III. Adrenochrome and Some of Its Derivatives, The Hallucinogens, by A. Hoffer and H. Osmond, 1967, Academic Press, (pdf in my Dropbox)
Excess of a copper based enzyme may be involved in schizophrenia but it seems protective, like a counteracting effect rather than being the enzyme causing excess adrenochrome conversion:
“Ceruloplasmin, a copper protein enzyme, normally present in serum oxidizes catechol, adrenaline, serotonin, and other amines. Leach et al. (1956) believed it was the catalyst in the oxidation of adrenaline to adrenochrome. Akerfeldt (1957a,b) found that N,N-diethyl-p-phenylenediamine was a useful substrate for measuring ceruloplasmin levels. Akerfeldt reported that schizophrenic patients generally were higher in ceruloplasmin thus supporting the suggestion of Angel et al. (1957) that schizophrenic serum converted more adrenaline into adrenolutin.” (page 315)
“Melander (1957) found that ceruloplasmin absorbs adrenolutin.” (page 316) Chapter III. Adrenochrome and Some of Its Derivatives, The Hallucinogens, by A. Hoffer and H. Osmond, 1967, Academic Press, (pdf in my Dropbox)
The alleged anti-aging effect of adrenochrome may be a reduction in cell division - cells survive longer before dividing into two new cells.
“However, we would expect that schizophrenics would have less clear diurnal rhythm of mitosis if they really do have increased concentrations of adrenochrome. Increased quantities of adrenochrome-chalone would suppress mitosis and promote cell survival. Schizophrenics would be expected to have better cell survival rates and, indeed, many schizophrenics do appear to be remarkably youthful in appearance.” (page 317) Chapter III. Adrenochrome and Some of Its Derivatives, The Hallucinogens, by A. Hoffer and H. Osmond, 1967, Academic Press, (pdf in my Dropbox)
Potential treatments for patients with schizophrenia:
“Adrenaline Oxidase Inhibitors. Payza and Hoffer (1959) found only 4 inhibitors of this enzyme, sodium cyanide, ethylenediaminetetraacetate (EDTA) tris buffer and ascorbic acid. Sodium cyanide could not be tested as an hallucinogen. In nontoxic doses it has produced lucid episodes in some schizophrenic patients. EDTA has not been used clinically and its toxic properties are not known. We would expect it to be nontoxic and, in fact, therapeutic for schizophrenics as is penicillamine. Both are copper chelating agents and by removing copper would inhibit adrenaline oxidase. G. J. Martin et al. (1942) found that p-aminobenzoic acid inhibited oxidation of adrenaline to adrenochrome by tryosinase. We have not heard of any psychotic reactions following the use of heavy doses of PABA. In its absence convulsions may develop. PABA should be therapeutic for schizophrenia.
Inhibitors of tryosinase also include cysteine, thioureas, glycine, and histidine (Hirsch, 1959), and monohydroxybenzoic acid isomers (Yasunobu, 1959). Benzoic acid itself is a good inhibitor. These compounds may be valuable therapeutic chemicals for some schizophrenics, dPhenylalanine is another inhibitor and is believed responsible for the deficiency of melanization in phenylpyruvic oligophrenia.” (page 336) Chapter III. Adrenochrome and Some of Its Derivatives, The Hallucinogens, by A. Hoffer and H. Osmond, 1967, Academic Press, (pdf in my Dropbox)
The chapter includes detailed accounts by the researchers who tried the adrenochrome.
The firsthand experiences written after the trial and observers accounts are included.
» The biggest take home point is most of the people trying it did not recognize how changed their behavior was. Loss of good judgement, paranoia, irritability were all frequent symptoms along with changes in depth perception and other visual hallucinatory effects - no longer safe to drive was perceived by most but the researchers suggest not leaving people alone when using adrenochrome for research or therapy purposes.
This was early days in the discoveries - a brand-new chemical being isolated. Throughout the chapter the authors make it clear that there was controversy at the time - discovery of adrenochrome/adrenalin metabolism was being questioned/disbelieved.
With my recent hair loss, alopecia areata onset, one of the supplements that I stopped taking (had been a fairly recent addition) was extra copper. I take high dose zinc for pyroluria and there is a potential risk for low copper then, but my genetics may be odd enough that I really don’t need the copper because the excess zinc is being continually wasted during pyroluria in urinary loss. When I slack on taking my many supplements, the negative symptoms match low vitamin B6 and low zinc quite well. Low glycine symptoms like salicylate excess, and apparently adrenochrome excess, are also what stand out when I slack on my supplement routine. I have been feeling quite a bit better since mixing up a new batch of my Cheerful Juice (DMG & other amino acid supplement beverage).
While I am still losing some of the long hair (the white hairs went first), it has slowed and there definitely is a ‘five-o’clock-shadow’ growing back in some areas. I am just going to give it a little more time before cutting the rest. It is likely going to look funny to have very short hair among long hair.
Excerpts from the Part 2 post:
Question - If elites are using adrenochrome rich blood (of terrorized children) for anti-aging or other purposes, then it likely is also causing lack of empathy, poor judgement, increased error rate -
…and lack of concern - a lack of realization that their behavior has changed and their empathy gone.
If you are feeling confident and not anxious, no worries, even apathetic - Worries don’t even matter! Big deal! Who cares if the car crashes into those people ahead? I don’t care! . . . then you are a danger to others. And yet you don’t realize that you are a danger to others. AND increased paranoia may leave you feeling that others are a danger to YOU - so maybe you should get them first?
Do you, my thoughtful reader, see where there could be problems in use of a substance that makes you not care about hurting other people? And maybe also makes you feel that you are right and correct and should do whatever it is that seems sensible to do at the current moment — like take off your oxygen mask while deep under the sea! Just swim with the fishes! Everything will be fine!
…yeah, no it won’t. Do not take off your oxygen mask while deep under the ocean even if the high-pressure oxygen level has caused your body to produce adrenochrome and it is making you think wacky wrong thoughts.
~~
The cover-up of this information is likely to protect the elicit use of adrenochrome by the powerful and connected people and protect those users from public scrutiny or disapproval of the icky and evil product.
» The cover-up though, has left patients with schizophrenia symptoms untreated except for those who see a few independent doctors like Abram Hoffer, MD.
The cover-up may also be to keep scared people making more adrenochrome in their own terrified body. Trial use of adrenochrome or adrenolutin usually did not leave lingering personality changes, but occasionally did for a few days. A child that grew up with chronic insecurity and unresolved fear may be forming some changes in their body that leaves them more prone to making adrenochrome from adrenaline rather than breaking it down into safer molecules. There has been some suggestion that increased fear is desired by energy beings who like fear energy (rather than love and gratitude energy). There is a more concrete theory that fearful subjects are more controllable, more easily led to accept thoughts that were implanted rather than their own original thoughts.
Post 2 gets into the Fear aspects of the CoV Feardemic and how that might have been purposefully feeding into adrenalin/adrenochrome chemistry. And some herbals that might help. I have clipped the adrenochrome sections.
The researchers were on the cutting edge of science - discovering the properties and isolation methods of new chemicals.
{Name dropping tangent - Hoffer and Osmund got some of the adrenolutin from Pfizer. It was unstable and hard to obtain, not a standard lab chemical.}
Chapter III. Adrenochrome and Some of Its Derivatives, The Hallucinogens, by A. Hoffer and H. Osmond, 1967, Academic Press, (pdf in my Dropbox)
The researchers tried the hallucinogens for themselves - first mescaline and LSD and then the adrenochrome, taking their own notes and having a couple observer scientists take their own notes. Comparing the sets of notes revealed consistently that adrenochrome or adrenolutin caused significant behavior change in a person BUT the person didn’t believe it. They would think they had been given a placebo or a dud - they often thought that no change had occurred, or maybe a little bit of a depressant effect even though unusual irritability or other changes were obvious to their secretaries/staff or the observer scientists.
Chapter III. Adrenochrome and Some of Its Derivatives, The Hallucinogens, by A. Hoffer and H. Osmond, 1967, Academic Press, (pdf in my Dropbox)
The Chapter includes quite a few of the trials and observation notes and the repetition is clear - the stuff leads to reckless behavior - careless mistakes with no concern about it - apathy and loss of empathy were mentioned a lot; paranoia and irritability were frequent; odd thought connections - surreal word associations instead of logical interpretations, loss of understanding of proverbs like “A stitch in time saves nine” - although these days, who would know how to sew or that you sew with stitches and a threaded needle? Mend the tear when it is small and it is a quick job compared to ignoring it until it is a big tear that needs lots of stitches.
{Total aside - “We reap what we sow” - the seeds that we sow in a field. We do not reap/harvest the stitches that we sew in a piece of fabric. Old person checking in ;-)}
So - take home point for those of us with our Criminal Minds profiling hats on - people using adrenochrome likely are overconfident but prone to making reckless mistakes and likely wouldn’t care about any harm that might occur due to those mistakes. In other words - dangerous monsters but who don’t realize that they are acting like dangerous monsters.
Lying liars just keep lying - corollary here - they don’t realize they are lying because they have lost connection with reality - they don’t see that they are lying to themselves about their own actions, or they don’t see it/can’t perceive the impact of their behavior on others. Narcissists are fragile because they believe their fantasy image of themselves and can’t let it get any cracks in the candy coated shell.
How do we tell who they are? They might appear youthful with brown hair unless they dye it - otherwise, we wouldn’t really be able to tell. The experimenters and research subjects in larger trials usually did not get really obviously out of control or psychotic - like a full-blown case of ‘schizophrenia’. Observer judgement identified between who got a placebo or the adrenochrome or adrenolutin with more accuracy than screening tests for disordered thinking. It was subtle changes - off character would mean you would need to know the person’s norms to see that they were more irritable or making more mistakes than they normally would.
» In a person with schizophrenia, increases in adrenaline get turned into adrenochrome instead of safer aldehydes or sulfates. Adrenaline and adrenochrome are so reactive that it is stored in red blood cells because RBCs are so different than other cells - they have no cell nucleus with DNA that the reactive adrenaline chemistry to endanger.
Chapter III. Adrenochrome and Some of Its Derivatives, The Hallucinogens, by A. Hoffer and H. Osmond, 1967, Academic Press, (pdf in my Dropbox)
Adrenaline oxidase is the enzyme to inhibit, and monoamine oxidase is the one to promote, to help someone with schizophrenia to breakdown adrenalin instead of having it convert to adrenochrome.
I have a gene difference in my MAO enzyme and I have slow sulfate metabolism - tendency to accumulate excess of the toxic sulfides/sulfites. The biochemistry and gene alleles get confusing. It may be a lack of methylation issue too. Methylated adrenaline is not as toxic - the methyl transferase path straight downwards in Figure 8 to metanephrine.
Chapter III. Adrenochrome and Some of Its Derivatives, The Hallucinogens, by A. Hoffer and H. Osmond, 1967, Academic Press, (pdf in my Dropbox)
Table 27 suggests that people with schizophrenia could be chronically low in vitamin C from over-utilization due to excess oxidation, and also our endogenously made glutathione.
Therefore extra vitamin C in the diet or supplements could help (~ 250 mg/day to avoid excess uric acid if niacin is also being supplemented).
Glutathione support with any methylation cycle nutrients would be a need and adequate protein or supplements of N-acetyl cysteine and glycine as TMG/betaine or DMG. Which form of glycine would depend on the person’s gene alleles - I need the DMG because of a BHMT gene difference. It doesn’t taste great mixed in foods so I created my Cheerful Juice mix to help me get DMG in my daily diet.
If methylation cycle gene differences are also present then the person would need whichever support nutrients that are blocked by gene dysfunction, and some foods or supplements might need to be restricted to prevent over-accumulation in areas affected by dysfunction. The methylation cycles are like interlinked gears in a clockwork - if one gear is broken than all the clockwork stops spinning correctly. Where the blockage is can affect downstream or upstream chemicals within the linked pathways. Good diet is also part of it. Many nutrients are needed for methylation. Anyone can have bad methylation because of modern diet and add lifestyle inhibitors like alcohol or stress/formaldehyde and that will throw off the gears.
Nicotinic acid is the flush type of niacin. It is considered the “antidote” to adrenochrome and adrenolutin in the Table below.
A researcher who had a fairly bad experience and who needed to work clinically that night was given a high dose of niacin to help offset the adrenochrome trial. It worked. He regained normal thinking. See quote below.
Effects on personality sometimes lingered a few days after the adrenochrome or adrenolutin trials. People's reactions would vary a fair amount between minimal effect and kind of bad effects.
Chapter III. Adrenochrome and Some of Its Derivatives, The Hallucinogens, by A. Hoffer and H. Osmond, 1967, Academic Press, (pdf in my Dropbox)
Two points -
Schizophrenia patients are still being given electroshock ‘treatment’ instead of niacin.
Pedo-pie eaters seem to be in control of much of society and they are likely dangerous monsters who do not believe that they are dangerous monsters because of the effects of adrenochrome on their psyche.
Disclaimer This information is being provided for educational purposes within the guidelines of Fair Use and is not intended to provide individual health guidance.
Reference List
A. Hoffer and H. Osmond, ‘Chapter III. Adrenochrome and Some of Its Derivatives, The Hallucinogens’, 1967, Academic Press, (pdf in my Dropbox)
Every day I run into something new from you Jennifer which I have never encountered. I did not know about the connection between schizophrenia and Adrenochrome. The few people I know who suffer from schizophrenia are put on antipsychotic drugs. Thank you for sharing the light!
Every day I run into something new from you Jennifer which I have never encountered. I did not know about the connection between schizophrenia and Adrenochrome. The few people I know who suffer from schizophrenia are put on antipsychotic drugs. Thank you for sharing the light!