The Pangolin Who Got Away
Poetry for the CoV era, dedicated to Karl and Dan Sirotkin and all the others who have investigated Gain of Function cover-up.
Pangolin are peculiar
And armadillo like.
Nearly scapegoated as CoV carrier, but
Gain of Function, was
Obviously
Linked…
In a
Nearby mink farm outbreak – was the smoking mink really a lab ferret in disguise? Or a pangolin’s reprieve?
History is written by those who survive.
Related citation by Substacker
: Sirotkin K, Sirotkin D. ‘Might SARS-CoV-2 Have Arisen via Serial Passage through an Animal Host or Cell Culture?: A potential explanation for much of the novel coronavirus' distinctive genome’. Bioessays. 2020 Oct;42(10):e2000091. doi: 10.1002/bies.202000091. Epub 2020 Aug 12. PMID: 32786014; PMCID: PMC7435492. https://pmc.ncbi.nlm.nih.gov/articles/PMC7435492/
Additionally, a reply shared that a software program for tracking the variant changes of SARS-CoV-2 over time has the acronym “PANGOLIN”.
“Did you know that Pangolin is the name of the sequencing software used to track the linages of Sars Cov2'.
Phylogenetic Assignment of Named Global Outbreak Lineages
No, I didn’t know that, thanks!
Phylogenetic
Assignment
Of
Named
Global
Outbreak
Lineages.
….hmmm. I think the Pangolin need a new press agent.
Brave AI summary: Serial Passage in Gain-of-Function
According to the provided search results, serial passage research is a technique used in gain-of-function (GOF) studies to manipulate pathogens, such as viruses, and make them more deadly or transmissible. Serial passage involves allowing the virus to grow in different growth mediums, which can lead to mutations and alterations in the virus’s structure and function.
In the context of GOF research, serial passage is used to enhance the transmissibility and/or virulence of pathogens. This is done by repeatedly passaging the virus through a host, such as a cell culture or an animal model, allowing it to adapt and evolve over time. This process can result in the virus becoming more infectious, virulent, or transmissible, making it a valuable tool for studying potential therapies, vaccine development, and disease control.
For example, one of the search results mentions that serial passage is used to “make certain pathogenic microbes more deadly or more transmissible” and that this technique is essential for vaccine development, as it allows researchers to study the virus’s enhanced immunogenicity and viral yield.
It’s worth noting that serial passage research is a key aspect of GOF studies, and its application has been the subject of controversy and debate, particularly regarding the potential risks of creating more dangerous pathogens that could escape from laboratories and cause harm. (Brave AI Summary)
nap.nationalacademies.org, 4. Potential Benefits of Gain-of-Function Research
National Academies of Sciences, Engineering, and Medicine. 2015. Potential Risks and Benefits of Gain-of-Function Research: Summary of a Workshop. Washington, DC: The National Academies Press. https://doi.org/10.17226/21666.
empowerias.com, Gain-of-function research "EMPOWER IAS" | Empower IAS
ncbi.nlm.nih.gov, Selgelid MJ. Gain-of-Function Research: Ethical Analysis. Sci Eng Ethics. 2016 Aug;22(4):923-964. doi: 10.1007/s11948-016-9810-1. Epub 2016 Aug 8. PMID: 27502512; PMCID: PMC4996883. https://pmc.ncbi.nlm.nih.gov/articles/PMC4996883/
Disclaimer: This information is being shared for educational or entertainment purposes within the guidelines of Fair Use and is not intended to provide individual health care guidance.
Did you know that Pangolin is the name of the sequencing software used to track the linages of Sars Cov2'.
Phylogenetic Assignment of Named Global Outbreak Lineages
https://cov-lineages.org/resources/pangolin.html