Study design in nutrition - a link
How sloppy studies and ignorant scientists discredit vitamin D, by Dr. Simon, (substack.com).
My reply: Nice compilation - nutritionist 2 cents - vitamin D will not improve if the person is low in magnesium or the transport Vitamin D Binding protein/ GcMAF. Study design needs to include assessment of protein adequacy in the participant's diet and their ability to absorb magnesium. Poor gut absorption of magnesium may be an underlying factor in low vitamin D levels (and/or glyphosate interference with mineral and/or CYP enzymes).
*Addition, and some pathogens or conditions include over-conversion to the active 1, 25 D so a few patients may be harmed by high dose supplements while still showing low levels of 25 D -- it is being converted to 1, 25 D. (Older post on the topic of elevated 1, 25 D: Low vitamin D levels associated with increased LDL/HDL cholesterol ratio and triglyceride levels (substack.com).)
Excerpt regarding infectious causes of Vitamin D disruption: “Other pathogens that have been shown to reduce the activity of the Vitamin D Receptor, in addition to the pathogen that causes Tuberculosis, include the mold Aspergillus, the viruses that cause Epstein-Barr chronic fatigue syndrome and HIV/AIDS, and the autoimmune diseases sarcoidosis, Crohn’s Disease, and Rheumatoid Arthritis. Elevated levels of 1, 25(OH)2D are seen with the bacterial infections: “Elevated 1,25(OH)2D appears to be evidence of a disabled immune system’s attempt to activate the VDR to combat infection.” (page 19, Mangin, et al, 2014)
And Dr Simon’s response: “True - same applies to Zinc. I wrote a publication about it: https://www.sciencedirect.com/science/article/pii/S120197122030624X”
Trace minerals are a team who are electrically active and share the same protein transport proteins, which keep the minerals at a neutral and safe charge for the body. Vitamin D also needs a transport protein to keep it in the inactive 25-D form.
Trace minerals with typical doses that may be used, and/or limits for safety, and the electrical charges that trace minerals can have, are included on this webpage: Nutrients (jenniferdepew.com), along with the vitamins, A, B’s, C, D, E, K, and a couple amino acids. Mitochondrial support and other enzyme cofactors are listed in a similar style on this page: Cofactors (jenniferdepew.com).
It is time for an Epsom salt bath for me, and I need to shop for a full spectrum lamp for winter - I already miss the sun.
Supplements of vitamin D may not be as protective as getting real light or tanning booth light as the ratio of vitamin A to D may affect inflammation risks. In sunshine vitamin D is created and vitamin A is used up. (The reference/theory was somewhere in the Retinoid series) When we shift into winter months, suddenly vitamin D is not being created and vitamin A is not being used up = vitamin D deficit and vitamin A excess. This would be worse for someone who does over-convert retinoids. In all my traveling south during winter months, I felt better - even though I was living rough, out of my car mostly. I felt good and got healthier - and tanner.
I am now stuck in a northern climate without freedom to drive around aimlessly seeking pomegranate orchards or citrus peel juice factories. Fun days indeed. Now I need to sit and type it up - with a full spectrum light or bright lights on. Simply having more normal overhead lights on can help based on what I read about indoor lighting and vitamin D and A conversion - treat yourself like a jewel at the jewelry store or shiny new car under the bright lights of the car lot - and keep your life well lit!
*Blue light blocking glasses for the last three hours before bed or start toning down the lights to more of a campfire red glow. See: Sleep and health.
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*I added an update to my Thinking about Editing post, more about the Sections:
Editing advice from a friend. (substack.com)
Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
(Mangin, et al, 2014) Mangin M, Sinha R, Fincher K. Inflammation and vitamin D: the infection connection. Inflamm Res. 2014 Oct;63(10):803-19. doi: 10.1007/s00011-014-0755-z. Epub 2014 Jul 22. PMID: 25048990; PMCID: PMC4160567. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160567/