Self-amplifying mRNA 'vaccine' in the pipeline, and protective effects of EFT tapping & the polyphenol Fisetin.
Persimmons still rock! and pomegranate, green tea, goji berries, citrus peel, etcetera. Our brains are a high price to pay for modern living.
Physically clearing the brain with full-range motion is needed to help reduce amyloidosis and inflammation. A good night’s sleep and adequate water is part of toxin clearing through the glymphatic and lymphatic systems.
Stress coping mental techniques are also helpful as an angry or upset mood is physically increasing inflammation too. We can think ourselves sicker, but that means we can think ourselves healthier too!
EFT tapping can reduce emotional or physical pain and help with addictive patterns too!
Vagal Nerve stimulation and mood calming technique: EFT, Emotional Freedom Technique involves gently tapping along the route of the vagal and other nerves in a set pattern so you don’t have to think about it once you learn it. The series follows along an Acupressure channel. Statements are repeated with the tapping which help to breakthrough subconscious blocks that are in the way of change.
Old patterns or trauma from our past can still be non-verbally affecting our daily actions or choices without a clear reason why. Why do I keep saying I want to do whatever, but I never seem able to get going on it? Non-verbal fear or pain may be interfering and the wording of EFT techniques can help bypass without needing all the ancient details.
Introduction to EFT, a free mini-course, theeftcentre-s-school.thinkific.com.
Fisetin and other polyphenols directly reduce inflammation in many ways.
Polyphenols like fisetin found in persimmons help prevent senescence, (Tavenier, et al., 2024) , - ‘zombie’ senescent cells from hanging around dysfunctional but still taking in nutrients, long after they should have been removed. Fisetin also helps reduce amyloidosis. (Ahmad, et al., 2017; Pal, et al, 2016)
Senescent cells increase inflammation in surrounding cells too, by producing inflammatory chemicals and the normal waste products of a cell.
“Senescence is a hallmark of aging, characterized by irreversible growth arrest of cells. (Regulski, 2017) Cellular senescence occurs with increasing age or in response to various stressors, including a buildup of reactive oxygen species or ROS—unstable compounds that cause oxidative stress and can damage cells and DNA.” (Glosz, prohealth.com)
Polyphenols like fisetin can help modulate which proteins are being made in a cell and reduce inflammation directly by reducing the amount of inflammatory signaling chemicals that are made. They affect which microRNA are broken down and that affects which messenger RNA will be transcribed into a protein. Genes don’t rule life, or health, which genes get made are more in control, and plant polyphenols can control those… making this into a confusing question of Which came first? the chicken or the egg… or the persimmon? (Clearly the fern came before the chicken, the egg, or the persimmon.)
“Fisetin (3,3',4',7-tetrahydroxyflavone) is a dietary flavonoid found in various fruits (strawberries, apples, mangoes, persimmons, kiwis, and grapes), vegetables (tomatoes, onions, and cucumbers), nuts, and wine that has shown strong anti-inflammatory, anti-oxidant, anti-tumorigenic, anti-invasive, anti-angiogenic, anti-diabetic, neuroprotective, and cardioprotective effects in cell culture and in animal models relevant to human diseases.” (Pal, et al, 2016)
Fisetin and Its Role in Chronic Diseases. (Pal, et al, 2016)
Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases. (Tavenier, et al., 2024)
Neuroprotective Effect of Fisetin Against Amyloid-Beta-Induced Cognitive/Synaptic Dysfunction, Neuroinflammation, and Neurodegeneration in Adult Mice. (Ahmad, et al., 2017)
Fisetin: A Look at Fisetin: Is Intermittent Supplementation Best? By Cambria Glosz, MS, RD
Quote via Sam Knowlton, Wendell Berry sums up our current health predicament perfectly...
“People are fed by the food industry, which pays no attention to health, and are treated by the health industry, which pays no attention to food.” (x.com)
Sam has a Substack with older posts, he writes about agriculture and environment and has more recent posts on X.com.
An excellent Thread Sam Knowlton posted today about the Jena Experiment can be viewed on ThreadReaderApp.com. The Jena experiment compared garden plots over decades and found that diversity is a definite advantage if the species have more than a couple years to adapt into a synergistic community that is beneficially supporting the growth of each other. Monoculture does not have the rich soil diversity or interaction with mycorrhizal species making nutrients more bioavailable to plants.
More self-amplifying mRNA “vaccines” intended to “prevent” Covid19 are being recommended in Europe. via x.com/VaccineMole
Fisetin and other polyphenols would help protect against the chimeric spike from wherever we bump into it. A man-made nightmare is endemic amongst us. Fisetin may protect against Epstein-Barr virus, (Li, et al., 2014), which SARS-CoV-2/chimeric spike may have some similarities with but invading endothelial cells along blood vessels instead of favoring epithelial skin cells. (EBV & epithelial cells, Brave AI summary) SARS-CoV2 affects endothelial cells… (Romero, et al., 2023)
Let Mother Nature handle the biochemistry - she has made an intricate crystal chandelier while we are still fumbling in the dark looking for a light switch.
“Persimmons are not born soft,"
"But they are valued for their softness."
"Their ripeness.”
― Yiyun Li, (Goodreads)
Is the world ripening you? sweetening and softening you?
or hardening you further?
Polyphenols can help protect our brains from modern inflammatory issues whether EMF, air pollution, or chimeric spike effects.
Brave AI summary - Fisetin and MicroRNA Control
Based on the provided search results, here’s a concise answer: Fisetin, a dietary antioxidant, has been shown to regulate microRNAs (miRNAs) and their targets in various biological processes. Specifically:
miR-378 regulation: Fisetin protects against hepatosteatosis in mice by inhibiting miR-378, a miRNA involved in lipid metabolism (PMID: 33345431).
NF-κB signaling pathway: Fisetin interferes with targets of the NF-κB signal transduction pathway activated by Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) in nasopharyngeal carcinoma cells, suppressing NF-κB activation and its downstream targets, including CyclinD1 (PMID: 33345431).
miRNA expression profiling: Fisetin treatment alters the expression of multiple miRNAs, including miR-1, miR-133, and miR-378, in cardiac and skeletal muscle cells, suggesting a role in modulating muscle development and disease (PMID: 33345431).
These findings imply that fisetin may exert its biological effects, including anti-cancer and anti-inflammatory activities, at least partially through its regulation of microRNA expression and function. However, further research is needed to fully elucidate the mechanisms underlying fisetin’s miRNA-mediated actions.
pubmed.ncbi.nlm.nih.gov, MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions - PubMed
ncbi.nlm.nih.gov, Fisetin: A Dietary Antioxidant for Health Promotion - PMC
pubmed.ncbi.nlm.nih.gov, Fisetin as a promising antifungal agent against Cryptocococcus neoformans species complex - PubMed
pmc.ncbi.nlm.nih.gov, MicroRNA Control of Muscle Development and Disease - PMC
pubmed.ncbi.nlm.nih.gov, Fisetin protects against hepatosteatosis in mice by inhibiting miR-378 - PubMed
pubmed.ncbi.nlm.nih.gov, How microRNAs control cell division, differentiation and death - PubMed
pubmed.ncbi.nlm.nih.gov, Li R, Liang HY, Li MY, Lin CY, Shi MJ, Zhang XJ. Interference of fisetin with targets of the nuclear factor-κB signal transduction pathway activated by Epstein-Barr virus encoded latent membrane protein 1. Asian Pac J Cancer Prev. 2014;15(22):9835-9. doi: 10.7314/apjcp.2014.15.22.9835. PMID: 25520114. (Li, et al., 2014)
“Which is this?
This is persimmons, Father.
Oh, the feel of the wolftail on the silk,
the strength, the tense
precision in the wrist.
I painted them hundreds of times
eye's closed. These I painted blind.
Some things never leave a person:
scent of hair of one you love,
the texture of persimmons,
in your palm, the ripe weight.”
― Li-Young Lee, Rose
Disclaimer: This information is being provided for educational purposes within the guidelines of Fair Use and is not intended to provide individual health care guidance.
Reference List
(Ahmad, et al., 2017) Ahmad A, Ali T, Park HY, Badshah H, Rehman SU, Kim MO. Neuroprotective Effect of Fisetin Against Amyloid-Beta-Induced Cognitive/Synaptic Dysfunction, Neuroinflammation, and Neurodegeneration in Adult Mice. Mol Neurobiol. 2017 Apr;54(3):2269-2285. doi: 10.1007/s12035-016-9795-4. Epub 2016 Mar 5. PMID: 26944285.
(Pal, et al, 2016) Pal HC, Pearlman RL, Afaq F. Fisetin and Its Role in Chronic Diseases. Adv Exp Med Biol. 2016;928:213-244. doi: 10.1007/978-3-319-41334-1_10. PMID: 27671819. https://link.springer.com/chapter/10.1007/978-3-319-41334-1_10
(Regulski, 2017) Regulski MJ. Cellular Senescence: What, Why, and How. Wounds. 2017 Jun;29(6):168-174. PMID: 28682291. https://pubmed.ncbi.nlm.nih.gov/28682291/
(Romero, et al., 2023) Romero, M.J., Yue, Q., Singla, B., Jürg Hamacher, Hamacher, J., Sridhar, S., Moseley, A.S., et al., Direct endothelial ENaC activation mitigates vasculopathy induced by SARS-CoV2 spike protein, Front. Immunol., 09 August 2023, Sec. Inflammation, Vol 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1241448 https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1241448/full
(Tavenier, et al., 2024) Tavenier, J., Nehlin, J.O., Houlind, M.B., Rasmussen, L.J., Tchkonia, T., Kirkland, J.L., Ove Andersen, Hartmann Rasmussen, L.J., Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases, Mechanisms of Ageing and Development, Vol 222, 2024, 111995, ISSN 0047-6374, https://doi.org/10.1016/j.mad.2024.111995. https://www.sciencedirect.com/science/article/pii/S0047637424000952