Revised update - I did submit my paper!

I had emailed a higher-level contact with questions and he replied this morning, (11-13), and I did submit!

“Dear Dr Depew

We are pleased to inform you that we have received the manuscript "Pomegranate products, (Punica granatum), for the pain of histamine excess; inhibits NF-κB and mast cells, promotes Nrf2 and butyrate-producing microbiome species." to be considered for publication in…”

*I keep mentioning that I am a Registered Dietitian, but the correspondence is always addressed with ‘Dr.’. Honorific - I do feel honored :-) now all I need is a doctorate degree.

I can always write a patient guide-oriented book or series too, with recipes.

There is a screening process, not all submissions make it to peer review and those that make it need enough approvals to be published. So, I am trying and I feel good about that. It may help.

The tl'dr / Manuscript Contributions to the Field

Pomegranate is clearly beneficial, yet why is not fully understood. Bitter taste receptors as coregulators of the leptin receptor, T-type calcium channels, and some TRP channels may be part of the mechanism of action. This could explain why zinc adequacy is beneficial for leptin excess and why pomegranate ethanol extract shows more benefits for weight loss than aqueous extracts - more bitter caffeic acid content. Leptin triggers mast cell degranulation and is linked to obesity but also to inflammation. Retinoid Toxicity also increases histamine and both problems are likely to be undiagnosed yet may lead to suicide or later organ damage when left untreated. Zinc deficiency also reduces butyrate species which promote leptin in low-moderate fat diets, while pomegranate promotes Firmicutes. Butyrate or niacin also coregulate some TRP channels, reducing inflammation, inhibiting mast cell degranulation and promoting mitochondrial function. Heterogenous conditions require n=1 or self-controlled studies as the variables are numerous and the solutions are individual. Guidance examples are included for lifestyle and diet changes that may be needed to reduce histamine excess and restore more normal function. Pomegranate can help acute symptoms and reduce long-term degeneration but cannot stop the inflammatory inputs of modern life and the modern diet.

Pomegranate arils/seeds. Photo by Tamanna Rumee on Unsplash

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