Retinoid toxicity fans - liver damage hypothesis article.
The team recognizes the problem, they just don't know why. The why may be the EBV gene change being made by SARS-CoV-2 instead, and it leads to ME/CFS diagnosis for some patients. & my 2nd Table.
This team's hypothesis (Mawson, et al, 2021) would conflict with the idea that it is the spike causing endothelial damage (which is definitely happening in the jabbed - the Lipid Nanoparticles seem to like to collect along blood vessel walls and cause damage there).
The research team is suggesting that the excess inflammation caused by SARS-CoV2 or spike is leading to excess Retinoic Acid/retinoids, which may be causing further inflammation, which then can cause membrane breakdown.
Addition - the (Mawson, et al, 2021) paper did not include any mention of Retinoic acid causing differentiation of endothelial cells, or that SARS-CoV-2 likes to infect differentiated endothelial cells. They do make the point though, that the evidence showed inflammatory damage, rather than infected cell damage in the cases being discussed - fast deaths, more of a cytokine storm reaction rather than a chronic LongCovid type of ME/CFS. The paper includes a few possible mechanisms of action for a short-term retinoid excess in susceptible people, elderly, or a couple gene differences.
“The precise mechanisms of the pathogenesis and how liver injury relates to distant organ damage and the other manifestations of COVID-19 disease remain unknown. Tissue damage from thinning and leaky blood vessels [endothelial tissue] appears to result from an inflammatory response to the virus rather than from the virus itself. For instance, in a study of the brains of 19 patients who died shortly after contracting COVID-19, there was evidence of microvascular blood vessel damage but no evidence of SARS-CoV-2, suggesting that the neurological damage was caused by a disease-induced inflammatory response rather than by a direct viral attack on the brain (17). This article presents empirical evidence suggesting that the inflammatory factor responsible for tissue damage in COVID-19 is a high concentration of retinoic acid or retinyl esters.” (Mawson, et al, 2021)
Excerpts from the supporting evidence sections:
Regarding corticosteroids: “A 62-year-old woman with acute promyelocytic leukemia was treated with all-trans retinoic acid. On day 2 she suffered with dyspnea and general fatigue. Marked hypoxia suggested the occurrence of retinoic acid syndrome. She underwent endotracheal intubation and mechanical ventilation with the administration of dexamethasone. Her symptoms promptly abated. She was subsequently treated with conventional chemotherapy and achieved complete remission (6).
These data support our hypothesis that corticosteroids are effective in the treatment of COVID-19 by reducing or inhibiting retinoic acid.” (Mawson, et al, 2021)
Regarding Interferon and a gene difference: “Additional recent evidence indicates that ∼14% of cases of severe COVID-19 either have genetic flaws in IFN production or antibodies that attack IFN itself, leading to reduced serum IFN or an inability to produce IFN (2,39). Although retinoic acid can potentiate the action of IFN on viral replication (32), supplementary or excess retinoic acid can have the opposite effect of impairing immune function and exerting toxic effects regarding oxidative metabolism and mitochondrial function (7). (Mawson, et al, 2021)
Background information, and a clue for new readers to understand the blurb below - Retinoid toxicity would also cause histamine excess among other problems:
New addition to the above link:
Table 2 or 1. Symptoms of histamine excess and symptoms of Retinoid Toxicity are very similar.
*Imagine this as a Table. In the research paper linked above.
Hyperinflammation can lead to cell death.
Histamine Excess: Increased IL-6 and NF-kB. (Park, et al, 2014) Cell death can occur.
Retinoid Toxicity: Vitamin A deficiency increases NF-kB. Activated Retinoic Acid can reduce NF-kB and IL-6 levels. (Austenaa et al, 2004) Inflammation will lead to depletion of retinol as it is converted to Retinoic Acid and deficiency will then increase inflammation more. (Sarohan et al, 2021) Cell death can occur. (De Oliveira, 2015)
Skin and Bone effects of Histamine Excess and Retinoid Toxicity.
Skin, Histamine Excess: Rash in histamine excess tends towards hives. Skin reddening very easily and staying red briefly – being able to write on yourself with your fingernail can occur in histamine excess.
Skin, Retinoid Toxicity: “Mucocutaneous effects include dry lips, cheilitis, and dry oral, ophthalmic, and nasal mucosa. The putative mechanism is decreased sebum production, reduced epidermal thickness, and altered barrier function. Other cutaneous effects seen include overall skin dryness and pruritus, peeling of palms and soles, and fingertip fissuring. Telogen effluvium may be seen with higher doses.” (Olson et al, 2020) Telogen effluvium is hair loss and thinning without scarring, the problem may be acute or chronic. (10)
Bone, Histamine excess: Histamine increases inflammation in osteoarthritis. (Wang et al, 2019)
Bone, Retinoid Toxicity: Bone spurs, calcinosis, and hypercalcemia. (Scheven, Hamilton, 1990) Risk of osteoporosis and hip fractures. (Genaro Martini, 2004) (Olson et al, 2020)
Metabolism - thyroid and blood lipid, sugar, and weight effects.
Hypothyroidism, Histamine excess: Hypothyroidism may increase expression of mast cells & histamine risk, or MCAS may affect thyroid functions. (Landucci, et al, 2019)
Hypothyroidism, Retinoid Toxicity: Hypothyroidism. (Sherman, et al, 1999) (Olson et al, 2020)
Blood chemistry, histamine excess: Histamine is involved in blood lipids, glucose, insulin, and weight. (Masaki et al, 2001)
Blood chemistry, Retinoid Toxicity: Hypertriglyceridemia and other blood lipid changes, (Koo, et al, 1997) (Duvic, et al, 2001) Rare – also acute hemorrhagic pancreatitis and eruptive xanthomas. (Olson et al, 2020)
Liver damage.
Hepatic dysfunction, Histamine Excess: Hepatomegaly, fibrosis. (Yam et al, 1986) Either excess or too few mast cells in the liver can lead to fibrotic damage. (Jarido et al, 2017)
Hepatic dysfunction, Retinoid Toxicity: Elevated serum transaminases and liver damage leading to fibrosis and hepatic stellate cell activation. (Nollevaux, et al, 2006) (Olson et al, 2020)
Kidney damage.
Renal Dysfunction, Histamine Excess: Renal dysfunction. See Fig 3. Acute Kidney Injury, diabetes, and hypertension. (Sudarikova et al, 2021)
Renal Dysfunction, Retinoid Toxicity: Renal dysfunction. (Cribier, et al, 1992) (Olson et al, 2020)
Neurological symptoms.
Headaches, Histamine Excess: Migraines may be frequent and severe. (Personal experience.)
Headaches, Retinoid Toxicity: Headache, nausea, and vomiting; rare -pseudotumor cerebri syndrome. (Chisholm, et al, 2018) (Olson et al, 2020)
Anxiety/other, Histamine Excess: Extreme anxiety, fear, suicidal ideation, mania, hyperexcitability. (Personal experience/citations needed)
Anxiety other, Retinoid Toxicity: Possible link: depression, psychosis, or suicide attempts. (Bigby, 2008) (Olson et al, 2020) “Confusion, irritability, anxiety, depression, and suicide ideation.” (Snodgrass, 1992) Schizophrenia like ‘hysteria’ after eating polar bear liver. (Rodahl, Moore, 1943) (Restak, 1972) (De Oliveira, 2015)
Dopamine imbalance, Histamine Excess: Dopamine & ROS levels would be elevated during histamine excess and hyperexcitability episodes.
Dopamine imbalance, Retinoid Toxicity: Effects on neuronal function may include: “impaired bioenergetic parameters related to mitochondrial function, oxidative and nitrosative stress, alterations of dopamine signaling, and behavioral disturbances.” (De Oliveira, 2015)
Lab measurements that might be informative.
Histamine Excess: “In humans, although the plasma histamine levels were low (< 1 ng/mL) in normal conditions, 17 out of 54 patients with atopic eczema showed plasma histamine concentrations ranging between 1.2 and 5.2 ng/mL.7” ((Ubuku 2021) viewable at ScienceDirect)
Vitamin A Toxicity - Retinol in the liver: Normal level of Vit A in the liver (1H-retinol) “is about 100 µg/g (Furr et al. 1989). […] roughly 300 µg/g in the liver reveals intoxication (Olson 1993). ” (De Oliveira, 2015) Measurements of retinoids and retinol may vary in different parts of the body. Retinol is low in the alcoholic liver and eyes, leading to night blindness, while other areas of the alcoholic person’s body has excess Retinoic Acid. The gene change seen in Epstein Barr Virus ME/CFS patients may also lead to the liver showing low levels of retinol while the rest of the body may be experiencing elevated amounts of the activated forms of Retinoic Acid.
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There seems to be a pattern in the table above (the imaginary table).
Retinoid Toxicity is a complex problem but the solution is really simple in some ways - just stop eating vitamin A rich foods - of course that is many common foods and a huge change to the diet - but possible. *Addition - histamine excess though adds another more complex list of things to avoid, and there are flickering lights, stress, and strong EMF to watch out for too.
The results can be a return to a rational calm mind instead of feeling like the world would be better off if you would just not be there anymore. The irrational thinking of histamine hyperexcitability is overwhelming and makes it hard to remember that there ever was anything but the whirling overstimulation.
Quiet calm timeout with dim lighting is needed, and a cup of pomegranate juice or 4:20 break would help (medical marijuana THC and or CBD drops or smoke - also inhibits mast cells). Not having the whirling madness is much better. Suicide is a recklessness risk, that is why guns are so dangerous in the hands of someone at risk - too fast, too effective.
Oh . . . and over time the problem can damage your kidneys, liver, pancreas, bones, thyroid and hippocampus too.
Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
Reference List
Mawson AR, Croft AM, Gonzalez-Fernandez F. Liver Damage and Exposure to Toxic Concentrations of Endogenous Retinoids in the Pathogenesis of COVID-19 Disease: Hypothesis. Viral Immunol. 2021 Jul-Aug;34(6):376-379. doi: 10.1089/vim.2020.0330. Epub 2021 May 13. PMID: 33983857; PMCID: PMC8392079. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392079/