Peter C. Gotzsche explains why pharma co's meet definition of organized crime - video.

Via Pierre Kory, MD; and Gotzsche discusses the harm, from side effects or errors, of medications and multiple med use in the elderly. & a Twitter Thread including Zyprexa/olanzapine info.

Twitter Thread by Alexandros Marinos, @alexandrosM·Oct 18:

Deconstructing Evidence-Based Medicine... from the inside out.

At first, I was shocked with what I was finding. How could anyone not have seen this? Well, I was wrong. People have DEFINITELY seen it. And have spoken out. In peer-reviewed journals. Nobody (in power) cares.

Let's start with this excellent paper by Leonid Hanin: https://bmcmedresmethodol.biomedcentral.com/articles/10.1186/s12874-017-0399-0#Sec7 An incredible piece that is extremely readable, and uncovers the whole mess.

"Oh come on, Alex, this is some prof from Idaho with a 23 h-index. Is this your refutation?" I've not even gotten started yet.

How about Dr Peter Gøtzsche, over 180 THOUSAND citations, h-index 103 (this means over 100 papers with over 100 citations EACH). Is he credentialed enough? Oh, yeah, he was also a founder and board member of the Cochrane Collaboration.

Alexandros Marinos @alexandrosM

Here he is explaining why large pharmaceutical companies meet the definition of organized crime:

Alexandros Marinos @alexandrosM

Here he is explaining how prescription drugs are the third leading cause of death:

youtu.bePeter Gøtzsche - Prescription drugs are the third leading cause of death

The Cochrane founder left, the quality changed.

The Publication of Fraudulent Ivermectin Meta-Analyses and Editorials by the High-Impact Medical Journals: Part 2

The Twitter Thread continues, lengthily, and can be read as a Substack:

Alexandros Marinos @alexandrosM

Turned this to a substack article, for those who prefer their twitter threads all in one place:

doyourownresearch.substack.comDeconstructing Evidence-Based Medicine... From the Inside OutThis piece is a little bit different than my usual fare. It started life as a Twitter thread. I am cross-posting it here because I hope it can serve as a reading list of material for people who have run into the same mess I did a year and a half ago (so they don’t also have to spend 18 months recons…

Very nice job what little I have read of it so far.

And a reply was reshared

DrPeterParry @p_parry1

I chose my words carefully, it might flow better at 1.25 speed or if you're in a rush even faster:

youtube.comFrom Evidence-Based Medicine to Marketing-Based MedicineDr Peter Parry is an Australian child & adolescent psychiatrist who has researched the “Pediatric Bipolar Disorder” diagnosis emanating from the USA, a diagn...

Along with these graphics:

Zyprexa is also called olanzapine and can cause weight gain and diabetes, and may lead to suicidal urges at withdrawal, so people stay on it even though gaining weight from the munchies. It prevents breakdown of endocannabinoids, so is not helpful when there is a deficiency. The body gets use to more activated receptors, then at withdrawal there is a sudden loss of activation and overpowering suicidal urges, for no particular reason or whatever your worries are - just overwhelming.

I don’t recommend trying it, the stopping is no fun. I weaned off very gradually by cutting tablets into smaller fragments, and then used ibuprofen every four hours during the withdrawal (takes about 3-4 days). There is not a clear citation trail for that, I worked it out from varied tidbits from the “munchies” clue. The side effect felt just like the munchies to me, so I started looking online for mentions of that and found a research oriented article that considered why.

Ibuprofen also prevents breakdown of cannabinoids so I thought it might help the withdrawal and it did somewhat.

The pharma company was charged/fined for covering up the adverse weight effects. Eli Lilly maybe.

~~March 25, 2016 post, "Quit stalling," is also a handy phrase; or Olanzapine may be dangerous to individuals and others:

A prescription medication was something that I hadn’t tried by choice however and I hadn’t been fully informed about how it functioned chemically. After trying it I learned that while it is effective in the short term over time negative side effects can get painful and reduce quality of life. What was worse though became obvious when trying to stop taking the medication — psychological withdrawal symptoms were very severe — worse than normal levels of bad mood that I had ever previously experienced and dangerously bad, risk of self injury or injury to others bad.

What I discovered about the medication’s chemical function within the body is that it prevents the breakdown of our natural cannabinoid, anandamide, our body’s equivalent of the euphoric cannabinoid found in marijuana, called THC. There are cannabinoid receptors in the prefrontal cortex that are involved in suicidal thoughts and which have been found in a research study to be overactive in some alcoholic and depressive patients. The medication Olanzapine/Zyprexa may be causing over-activity of this area of the brain in some patients and then if they try to stop taking the medication it is like the brain is suddenly having to withdraw after having gotten used to a constant over supply of THC/anandamide.

Several adverse medication reports have been provided to the FDA regarding this medication where a person killed a family member or acquaintance while the patient was either withdrawing from Olanzapine at the time, or had the prescription in their name but the exact timing of use was not known at the time of the adverse event.

I’ll have to keep looking for a different link that showed actual reports, but in the meantime here is a list of other adverse effects: [http://psychroachesadverseevent.blogspot.com/2009/03/zyprexa-adverse-reactions.html]

~~ I found more info, would you take a drug if this was the warning?:

“Withdrawal from Zyprexa should only be done under the care of a health practitioner. The safest way is to withdraw at an inpatient medical detox facility with a protocol that includes hydration, vitamins and supplements for biological balancing. Call us to talk to a Detox Advisor.”

I did think a strait jacket and being spoon fed soup sounded nice at the time, but I didn’t trust the medical system for help. They would be more likely to spoon feed more medications. I hid my kitchen knives and avoided high places.

Read more about the increased mortality rate in elderly and other woes of Zyprexa and Eli Lilly (yes, right name). I had this closed to public but I reopened it: Zyprexa, $4.8 billion in prescription sales in 2007, and diabetes may also become a side effect (transcendingsquare.com) It continues in this post: So, "we have nothing to fear but fear itself," psychiatrists and their prescription pads, an unhealthy microbiome, and the occasional suicide bomber (transcendingsquare.com)

via (https://twitter.com/alexandrosM/status/1582723978707472386?s=20&t=sUfPwuXpygYnj02qC_atgA).

Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.