PCOS and Citrus Peel updates and resistant starch for immune health and CoV resistance.
Retinoid imbalance, deficiency of the inactive vitamin A form may be involved in COVID illness and would affect vitamin D receptor metabolism too. Butyrate and likely niacin too, would be protective.
I just revised and added to my Polycystic Ovary Syndrome (PCOS) Protocol document. It now has more food sources for important nutrients (from the new Prenatal/Child webpage) and general diet and supplement guidance towards the end. PDF in my Dropbox: https://www.dropbox.com/scl/fi/1m4fs5ero8zrocelgjqex/PCOS-Protocol-262023-2.docx?dl=0&rlkey=rz6qf72py2xls9mir5cfa1m5r
I have also added a citrus peel prep and recipe section to the Citrus Peel page (jenniferdepew.com)
An old reply of mine to this post: The Criminal Censorship of Ivermectin's Efficacy By The High-Impact Medical Journals - Part 1, Pierre Kory, (substack.com):
Thanks for your work. Ivermectin is not the only inexpensive and effective treatment getting bad press or false research trials.
MedPage Today has a "vit D didn't help CoV type article. https://www.medpagetoday.com/meetingcoverage/asbmr/100656
Low vitamin A may be why it doesn't help, in addition to the fact that it is needed in advance of an infection rather than helping after autoimmune issues already occurred.
"The role of VitD has been recognized in the prophylaxis and treatment of COVID-19 [324], [325]. At high doses, VitD has been shown to decrease the severity and provide therapeutic benefit in the treatment of COVID-19 [326]. However, VitD supplementation did not seem to be effective in hospitalized seriously ill COVID-19 patients [327], which we believe is due to the depleted retinol and subsequently dysregulated retinoid signaling mechanisms [315]. The lack of response to the supplementation of VitD in these severe COVID-19 patients may have well been due to the dysregulated retinoid signaling [327] because VitD exerts its effect through retinoid signaling mechanism [321]. In this sense, an optimum response would be accomplished when the proper signaling cascades through both of VitD and retinoids converge." (Sarohan, et al., 2021)
This paper is something I am still reading as I just found it last night. It supports my work on CoV and passive exposure to jabbed self-care. Latest in a longer series about Retinoid Toxicity as an underlying cause of ME/CFS after EBV infection - I think it may be happening after CoV for some people too.
Vitamin A and D and thyroid function are all linked and magnesium is needed. Chimeric spike is likely reducing GI absorption of magnesium due to TRP channels being made dysfunctional at the ankyrin repeat domains.
Modern life is inflammatory - EMF/5G and glyphosate are likely risk factors too.
Sunshine and full spectrum light may help balance excess retinoid risks by using up vitamin A and helping us make more vitamin D.
“Highlights”
“Retinoid signaling plays a central role in the pathogenesis of COVID-19. Both vitamin A and vitamin D employ retinoid signaling.
A proper retinoid signaling establishes a balance between regulatory T cells and pro-inflammatory Th17 cells.
Dysregulated retinoid signaling suppresses Tregs and favors development of hyperinflammatory Th17 in COVID-19.
COVID-19 infection rapidly consumes body’s retinol leading to dysregulated retinoid signaling and hyperinflammation.
This causes cytokine storm leading to multi-organ system involvement.”
Microbiome health and short chain fatty acids are protective against TH17 excess, while long-chain fatty acids promote more TH1 and TH17 response in autoimmune encephalitis by reducing the short chain fatty acids. (Lu, et al., 2020)
“Treatment with short-chain fatty acids (SCFAs) ameliorated EAE and reduced axonal damage, suggesting that SCFAs may have a beneficial anti-inflammatory effect in MS. Conversely, by increasing the pathogenic Th1 and/or Th17 cell in the small intestine, treatment with long-chain fatty acids (LCFAs) reduced short-chain fatty acids in the gut and aggravated the disease.11” (Lu, et al., 2020)
Resistant starches and zinc in the diet and pomegranate peel extract promote butyrate species in the colon. See page Resistant Starch/Butyrate for more information (jenniferdepew.com) and page How Much Butyrate? for food or supplement information - take home point - we need quite a lot of resistant starch - not a capsule or spoon of fiber to add to a glass of water.
Nations where Bubble Tea is quite popular had less COVID19 during the initial outbreak - see graphic/meme: Resistant Starch/Butyrate for more information (jenniferdepew.com) The pudding recipe on page How Much Butyrate? is also modified to include fruit or licorice powder in recipes I’ve shared on Substack.
Cherry licorice tapioca/garbanzo flour pudding is delicious. (substack.com)
and related info:
Why pudding makes us happy - the melatonin/opioid tangent. (substack.com)
Pudding is also structured water so it may be helping our cytoplasm and general energy level.
We are symbionts and need to accept that and feed our beneficial species what the need to thrive - in order for us to thrive too.
Niacin and butyrate activate the same receptor type and both could be helpful as supplements too. Improving microbiome health is important for many reasons though, not just butyrate production.
Disclaimer: This information is being shared for educational purposes within the guidelines of Fair Use and is not intended to provide individual health guidance.
Reference List
(Lu, et al., 2020) Lu XY, Han B, Deng X, Deng SY, Zhang YY, Shen PX, Hui T, Chen RH, Li X, Zhang Y. Pomegranate peel extract ameliorates the severity of experimental autoimmune encephalomyelitis via modulation of gut microbiota. Gut Microbes. 2020 Nov 9;12(1):1857515. doi: 10.1080/19490976.2020.1857515. PMID: 33382357; PMCID: PMC7751635.
(Sarohan, et al., 2021) Sarohan, A.R., Kızıl, M., İnkaya, A.C., Mahmud, S., Akram, M., Cen, O., (2021). A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder, Cellular Signalling, 87, 2021, 110121, ISSN 0898-6568, https://doi.org/10.1016/j.cellsig.2021.110121. https://www.sciencedirect.com/science/article/pii/S0898656821002102