Note about notes, an open notebook.
I write about many topics because I am interested in many topics. Health itself is a vast topic - interconnected though. Research silos with specialists focusing on the minutia of one area of study creates disconnect that may prevent seeing the greater whole needed for health.
I like health and haven't had it consistently since early childhood. Many genetic differences in metabolism is part of my problem I've learned which makes it easy for me in some ways to see how important a body function may be in every day life - because I don't have it. This also means solutions that work for me may not work the same for people with typical genetic metabolism. It may help some people though. Metabolic problems can occur due to illness, older age, or malnutrition.
Learning is teamwork. I study what others have written and make notes so I may more easily find the information that I read again. The internet is a big place, full of wonderful information - finding it again is not always easy. My blogs are my notebook - open access in the hope that it may help lead others to finding useful information for their own purposes.
I like health and current medical system does not focus on prevention or early treatment guidance. You have to be quite sick to prove a need for a diagnosis or treatment and the treatment may just be a medication that makes overall health worse rather than being guidance to correct underlying differences and improve natural function. My approach is the early identification of problems and how to restore natural function. Genetic differences and nutritional needs are my main focus and area of more experience. I am learning, there is a lot to learn.
Based on what I have learned about my body's differences and chronic issues, paralysis, Alzheimer's dementia, liver and kidney injury may be in my future - I would rather not have to experience any of those - which means I have to figure out what I may need to do to prevent them - because the focus of western medicine is on treating problems after they are fairly severe and show up on a lab test.
If my notes can help other people or researchers too, on their own path towards learning, bonus.
*mentioned to my sister this morning - I would need a graduate degree (or several) to understand all of this stuff - and then it would still be hard. This is very advanced information - I am not an expert - point is - no one is. Prevention of organ damage in sepsis is not happening across the US with the Covid epidemic - prevention requires early treatment before too much damage and irreversible scar tissue is formed.
" The main mechanisms involved in the pathogenic cascade and in the evolution of sepsis are represented by the inflammatory response, immune response, and redox activity, followed by the involvement of cellular defects, which all lead to severe organ dysfunction. Adding to this phenomenon are severe respiratory infections; tissue hypoxia; acute kidney injury (AKI); metabolic imbalances; and, last but not least, derangements of the biological system as a whole. Through the augmentation of the inflammatory status and through the concomitant derangement of several organ functions, a high percentage of critical patients with sepsis develop multiple organ dysfunction syndrome (MODS), and finally death [8,10–12]. " (1)
"However, recent results have proven that cannabinoids are responsible for a decrease in the expression of certain pro-inflammatory cytokines such as IL-6, IL-12, IL-1, IL-2, and TNF-α." (1)
Disclaimer: Opinions are my own and the information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.
Reference List (my notes for further study re last post)
Anca Raluca Dinu, Alexandru Florin Rogobete, Tiberiu Bratu, et al., Cannabis Sativa Revisited—Crosstalk between microRNA Expression, Inflammation, Oxidative Stress, and Endocannabinoid Response System in Critically Ill Patients with Sepsis. Cells 2020, 9, 307; doi:10.3390/cells9020307, 28 January 2020 https://www.dropbox.com/sh/ux0r70xaszbnlj8/AAB4k6QoFRRM-XyKzacCs4-Pa?dl=0 "Furthermore, a series of important implications on inflammation and the immune system that are induced by the activity of cannabinoid receptors stimulated by the delta-9-tetrahydrocannabinol (∆9-THC) and cannabidiol (CBD) have been noticed. One of the most important is their ability to reduce the biosynthesis of pro-inflammatory mediators and the modulation of immune mechanisms. Different studies have reported that cannabinoids can reduce oxidative stress at mitochondrial and cellular levels. ... we wish to present the possible implications of cannabinoids in the most important biological pathways involved in sepsis, such as inflammation, redox activity, immune system, and epigenetic expression."
Tafti M, Ghyselinck NB. Functional Implication of the Vitamin A Signaling Pathway in the Brain. Arch Neurol. 2007;64(12):1706–1711. doi:10.1001/archneur.64.12.1706 https://jamanetwork.com/journals/jamaneurology/fullarticle/794818
Kathleen L. McCoy, "Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation", Mediators of Inflammation, vol. 2016, Article ID 5831315, 18 pages, 2016. https://doi.org/10.1155/2016/5831315 https://www.hindawi.com/journals/mi/2016/5831315/