Mitochondrial damage due to psychiatric & other medications.
*a review of my 'Disturbingly Transparent Table' on psych and other drugs causing mitochondrial damage due to nutrient depletion or for other reasons.
I found* an old Thread about nutrients commonly depleted by psychiatric meds... (this is an X post, I decided to try the paid service there. I am getting a bit more reach, but not much. Censorship still happens and now the search engine is pretty much useless on x.com compared to old Twitter. Firing 80% of the employees may have had a ripple effect, or disabling function was a goal. I don’t know.)
Mitochondrial support nutrients seem to be the common factor and are depleted by a lot of psychiatric and other medications. Testing new drugs or old 'grandfathered' drugs for their potential harm to mitochondria has not been a standard test of safety in drug development, >>> but it should be.
Many drugs have been found to be causing mitochondrial damage, which ultimately harms overall health to the person too. Our mitochondria make usable energy for us out of sugars and fats (and occasionally protein).
Use of psychiatric medications tends to cause a minor mental health problem to turn into a worse diagnosis with ongoing use of psychiatric medications. Anxiety or mild depression often becomes a diagnosis of Bipolar disorder or more severe depression.
Medications can deplete nutrients a lot, and so can an immune reaction to an infection or vaccine, or an overload of any type of stress depletes our supply of nutrients. A high sugar/simple carbohydrate diet also depletes nutrients because mitochondria need B vitamins and minerals in order to use the sugar and starch efficiently and refined foods have very little nutrients remaining from the original food.
(*by searching Brave for anything from my Twitter. X no longer seems to function as a searchable site for old posts and the search engine wasn't turning up any links from the site either. It just found Threadreader type links...hmmmmm. Honestly, this is devastating news. Twitter had been awesome as a search engine).
I had turned this initial data Thread, data that had been shared from a book, into a Table of data. Later, after seeing a pattern, I added columns showing which nutrient deficiencies are also related to schizophrenia or Alzheimer’s dementia (AD), Huntington’s (HD) and Parkinson’s disease (PD). Having a diagnosis of AD, HD, PD and schizophrenia often overlapped with having a deficiency of nutrients that promote mitochondrial health. That overlap is quite revealing.
See the Table: (later version, pdf) or a post about it: 'A disturbingly transparent Table', (post discussing the Table).
The Table of nutrient deficiencies associated with use of common psychiatric drugs; Alz. risk; schizophrenia risk; and depletion of mitonchondrial support nutrients... is part of my unpublished pomegranate paper. See: ‘Pomegranate Products for the Pain of Histamine Excess.’ copyright Jennifer Depew, RD (Pom pdf in my sync file).
📚Data about nutrients depleted by common psychiatric medications is from a Table published in the book 'Antidepressants, Antipsychotics & Stimulants', by Dr. D.W. Tanton, PhD, (2006).
"Adderall depletes: Vitamin B12, vitamin C, and potassium. 2. Prozac depletes: Vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B12, folic acid, vitamin C, vitamin D, CoQ10
Prozac...calcium, magnesium, manganese, selenium, sodium, zinc, and glutathione.
Paxil depletes: Vitamin B1, B2, B3, B6, B12, folic acid, vit C, vit D, coenzyme Q10, calcium, magnesium, manganese, selenium, sodium, zinc, & glutathione. 4. Zoloft depletes: Vit B1, B2, B3,
Zoloft...vitamin B6, B12, folic acid, vit C, vit D, CoQ10, calcium, magnesium, manganese, selenium, sodium, zinc, & glutathione.
Celexa depletes: Vit B1, B2, B3, B6, B12, folic acid, vit C, vit D, Co Q10, calcium, magnesium, manganese, selenium, sodium, zinc, & glutathione.
Wellbutrin/Zyban depletes: Vit B6, vit C, vit D, CoQ10, & sodium.
Remeron depletes: Vit B6, vit C, vit D, coQ10, & sodium.
Effexor depletes: Vit B1, B2, B3, B6, B12, folic acid, vit C, vit D, Co Q10, calcium, magnesium, manganese, selenium, sodium, zinc, & glutathione.
Risperdal depletes: Vit A, vit B1, B12, biotin, folic acid, carnitine, inositol, vit C, vit D, vit K, & calcium.
Zyprexa depletes: Vit A, vit B1, vit B12, biotin, folic acid, carnitine, inositol, vit C, vit D, vit K, & calcium. 11. Seroquel depletes: Vit A, vit B1, B12,
Seroquel...biotin, folic acid, carnitine, inositol, C, D, K, & calcium.
Depakote depletes: Vit A, B1, B2, B12, biotin, folic acid, carnitine, inositol, C, D, K, calcium, magnesium, & Essential Fatty Acids."
Source: 'Antidepressants, Antipsychotics & Stimulants', Dr. D.W. Tanton, PhD, (
2006).
👉 Data via @DrDanaBeez, thanks!
Brave AI regarding the topic:
Pharmaceuticals and Mitochondrial Damage
Mitochondrial damage is a potential side effect of various pharmaceuticals, affecting a wide range of organs and tissues. Here’s a summary of key findings from PubMed search results:
Mechanisms of Mitochondrial Damage
Reactive Oxygen Species (ROS) production: Increased ROS production can damage mitochondrial DNA, proteins, and membranes, leading to impaired mitochondrial function and dysfunction.
Electron Transport Chain (ETC) inhibition: Inhibition of ETC complexes can disrupt oxidative phosphorylation, leading to decreased ATP production and increased ROS generation.
Mitochondrial permeability transition: Opening of the mitochondrial permeability transition pore can lead to mitochondrial swelling, cytochrome c release, and apoptosis.
Mitochondrial DNA damage: Damage to mitochondrial DNA can impair mitochondrial function and increase the risk of mitochondrial dysfunction.
Pharmaceuticals Associated with Mitochondrial Damage
Antidiabetic drugs: Troglitazone, a thiazolidinedione, was withdrawn due to hepatotoxicity, which was linked to mitochondrial DNA damage and impaired ATP production.
Cholesterol-lowering drugs: Statins (e.g., Baycol, Zocor, Lipitor) have been shown to inhibit mitochondrial respiration and induce mitochondrial dysfunction in various tissues.
Antibiotics: Certain antibiotics (e.g., trovan, levaquin) have been linked to mitochondrial damage and dysfunction.
Pain medications: Aspirin and acetaminophen have been shown to induce mitochondrial damage and dysfunction in certain cell types.
Antidepressants: Selective serotonin reuptake inhibitors (SSRIs) have been linked to mitochondrial dysfunction and damage in some studies.
Clinical Consequences
Liver damage: Mitochondrial damage can contribute to liver toxicity and steatosis, potentially progressing to steatohepatitis and fibrosis.
Cardiac toxicity: Mitochondrial damage can impair cardiac function, leading to cardiomyopathy and arrhythmias.
Neurotoxicity: Mitochondrial damage can contribute to neurodegenerative disorders, such as Parkinson’s disease and Alzheimer’s disease.
Kidney damage: Mitochondrial damage can impair renal function, leading to nephrotoxicity and chronic kidney disease.
Future Directions
In silico modeling: Development of in silico models to predict drug-induced mitochondrial impairment can help identify potential mitochondrial toxicants early in the drug development process.
High-throughput screening: Wider acceptance of suitable animal models and high-throughput screening assays can facilitate the identification of biomarkers and the assessment of mitochondrial drug toxicity.
Translation to clinical outcomes: Better understanding of the relationship between mitochondrial dysfunction and clinical outcomes can inform the development of safer and more effective pharmaceuticals.
See: (Brave AI summary);
Some of the reference links:
Medication-induced mitochondrial damage and disease,
Drug-Induced Mitochondrial Toxicity in the Geriatric Population: Challenges and Future Directions,
Drug induced mitochondrial dysfunction: Mechanisms and adverse clinical consequences,
Prescription drugs and mitochondrial metabolism,
Mitochondrial Disorders: Medicines to Avoid,
https://www.medsafe.govt.nz/profs/PUArticles/June2017/MitochondrialDisordersMedicinestoAvoid.htm
Disclaimer: This information is provided for educational purposes within the guidelines of Fair Use. It is not intended to provide individual guidance. Please seek a health care provider for individualized health care guidance.
For other readers here looking for solutions to BZD Withdrawal Syndrome, here is a x-ref to Dr Depew's excellent substack
https://denutrients.substack.com/p/kudzu-an-invasive-but-medicinal-plant
I have experienced this. What about solutions