Methylation cycle gene differences as a cause of heart disease, Dr. James Roberts.
Targeted nutrient supplements can normalize the body's functions and a gene screening can make it less of a guessing game to find out what helps you feel better and what isn't helping or is harmful.
Informative website by Dr. James C Roberts, MD, FAAC, FAARFM, about gene differences affecting the methylation cycles and dietary or other possible solutions. He references work and a gene screening panel developed for autism screening by geneticist Amy Yasko, PhD.. He confirms some of her information and leaves open questions about other theories that he couldn’t confirm. The link is divided into linked sections and is quite long with sections for multiple common gene alleles known to negatively impact the methylation cycles in some way.
Depending on a person’s alleles, some supplements may be really critically helpful and others harmful - balanced function throughout the methylation cycles is the goal for restoring function for people on the autism spectrum or for people with symptoms of heart disease - Dr. Roberts’ focus.
His overview is helpful but he doesn’t use the rs_____ gene codes for individual alleles and typically writes as if there is only one allele of concern for any gene and that isn’t really true. Some variations may be functional or semi-functional while others might be very disruptive. It is helpful to know the specific allele that is being discussed.
I did find the lengthy discussion helpful though and it clarified that for my own worse alleles, methyl B12 may be super important for me to take daily along with riboflavin , B2, and B6 - and I also need methyl folate but the B12 seems more of an issue. Lack of vitamin B12 over time adds to nerve damage and can become irreversible if remains deficient chronically. Elsewhere I have learned that choline and phosphatidylcholine may be important for me to get enough of daily.
High dose niacin protocol may be particularly helpful for me as it would help the body remove toxins in addition to reducing oxidative stress/inflammation. I do take a vitamin B5, choline and B1 too. High dose niacin can mean the body needs a little extra of the other B vitamins too.
“While we cannot change your DNA, if we know your weak links we can create "nutritional workarounds" - we can supplement alternative pathways or withhold from your diet molecules that you cannot handle. If we do not address the Methyl Cycle abnormalities that underlie unexplained or chronic illness - well then the illnesses will remain chronic and unexplained, because it is the Methyl Cycle Abnormalities that predisposed you to ill health.” - Dr. James C. Roberts, MD, FAAC, FAARFM http://www.heartfixer.com/AMRI-Nutrigenomics.htm
I have gene allele CBS C677T which may reduce my risk of excess homocysteine accumulating due to other alleles, but increase my risk for too much sulfate or sulfites collecting which also has toxic symptoms. Several of my supplements and amino acid powders over than Dimethylglycine were adding to my sulfur excess and the symptoms of sulfite excess were quite bad - racing heart, a feeling of “Is it a heart attack or a panic attack?” Excerpts about sulfur sources are included below.
MTHFR and a need for methyl Folate and riboflavin to prevent elevated homocysteine. I have this one too.
People with a MTHFR allele did okay on their self-selected diet which likely had natural folate and riboflavin food sources. When switched to a folic acid supplemented diet (RDA level, 438 mcg/day) their homocysteine levels tripled to levels high enough to increase risk of chronic disease symptoms developing over time.
Folic acid competes with natural folate for people who can’t remethylate the inactive folic acid easily. This was somewhat confirmed in a prenatal study which showed: “#Supplementation w/ (6S)-5-MTHF appears as effective as #folic acid in maintaining #folate status while [decreasing] unmetabolized folic acid in #maternal plasma” J.P. Fanton (twitter.com/HealthyFellow) (Cochrane, et al., 2023
Regarding the COMT gene alleles and caffeine intolerance, (I have this too).
Regarding sulfur foods or supplements - CBS, BHMT, SUOX gene alleles (I have CBS and BHMT alleles)
Via
https://twitter.com/ClichyRose3/status/1690491385420607488?t=JHaZcZteK96E_GOukisHuA&s=19
Fixing your heart is an emotional and physical process. Peace be with you.
Disclaimer: This information is being provided for educational purposes within the guidelines of Fair Use and is not intended to provide individual health guidance.
Thanks for these posts about sulfur metabolism. I have CBS, BHMT alleles as well, I seem to be pretty dependent on TMG, and decided to suspend NAC supplementation for now. Functioning mostly pretty well, thankfully.