mAChR dysfunction in miscarriage -

First trimester losses; implantation may be negatively affected in particular.

Cholinergic dysfunction during pregnancy is a big negative for the baby, as demonstrated by snake bites in Brazil as an example group. Snake bite during pregnancy, though rare, is a ~ 37.5% risk for fetal loss or fetal or prenatal complications.

“According to a Brazilian study published in SciELO, only 5% of 157 patients with snakebite envenomation were pregnant, with 75% of these cases occurring in the first trimester. The study found that 37.5% of pregnant patients experienced obstetrical consequences, including vaginal bleeding, uterine contraction, threatened abortion, decreased fetal movements, absence of fetal heartbeat, and fetal death.” (Brave AI summary)

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A tangential fashion aside via Remnant MD - For better chance of conceiving, wear cotton or wool, or maybe silk, rayon or bamboo underwear - skip the polyester for better fertility as a female. It took five months of not wearing polyester for fertility to be restored in five of eight animals who became unable to conceive after 12 months exposed to polyester underwear (animal-based study). That says a lot about the negative effect of polyester on health - why it was negative is less sure. The effect of polyester on the skin electric fields was measured and progesterone levels were found to be diminished. (Shafik, 2008) Natural fabrics are protective against EMF and positive ions which polyester attracts. I have always found polyester fabrics to be itchy and generally only wear cotton clothing.

• Shafik, A. (2008). An experimental study on the effect of different types of textiles on conception. Journal of Obstetrics and Gynaecology, (Shafik, 2008)

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Miscarriage in the first few weeks of pregnancy is fairly common. Women in the past didn’t tell people they were expecting until after the first trimester. The baby belly only starts to show around month five or six. “Research suggests that between 10% and 20% of medically confirmed pregnancies will end in miscarriage, and 80% of these will occur during the first trimester.^{2” Miscarriage Risk for Asymptomatic Women after a Normal First-Trimester Prenatal Visit. Obstetrics & Gynecology. 2008.”}

“According to one study, here's the overall risk of miscarriage in asymptomatic pregnant people after detecting a heartbeat [typically first heard at ~ 5 1/2-6 weeks]:²

• Risk after 6 weeks: 9.4%

• Risk after 7 weeks: 4.2%

• Risk after 8 weeks: 1.5%

• Risk after 9 weeks: 0.5%

An older study found a 3.2% miscarriage rate after 8 weeks (it didn't differentiate between people with and without miscarriage symptoms).^{3” (parents.com/miscarriage)}

Prenatal complications and maternal mortality are more common for women of color and people in lower social economic brackets. (forbes.com) The pelvic shape of Sub-Saharan ethnicity is narrower, which adds to some prenatal risks for delivery. A yoga style pose can help relieve intrauterine pressure and reduce risks. And a darker skin complexion can increase risk of low vitamin D in areas with less direct sunshine and low vitamin D increases autoimmune risk and may increase risk of infection or other concerns. (effectivecare.info/G4. Vitamin D and Autoimmune Risk, G5. Preeclampsia & TRP channels)

However, miscarriage has become a lot more common after CoV injection era. Ten percent is the standard rate of early miscarriages - but 31% of women who got CoV injections prior to a pregnancy ended up miscarrying from VAERS data. This topic was being discussed in 2022, and this article was from 2023.

“31% of women who were exposed to COVID-19 products prior to pregnancy experienced a miscarriage according to VAERS domestic data — This is almost twice the upper limit background rate as per the CDC's v-safe calculations” - Jessica Rose, (Substack)

31% of women who were exposed to COVID-19 products prior to pregnancy experienced a miscarriage according to VAERS domestic data

The Pfizer trial data that was hidden showed 28 out of 29 pregnant women miscarried. Click through for brief audio stating those numbers: Nov. 13, 2023, (x.com/RikLesel).

Miscarriage risk became so known by young women that they knew a CoV injection could end an unwanted pregnancy.

“In early 2021 right after the vaccine came out I came across a discussion on Twitter about the vaccine side-effects and one young woman posted that she and all her friends knew that if they had an unwanted pregnancy, all they had to do was get a covid vaccine as they cause miscarriages.” Sparrow, Nov. 13, 2023, (x.com/jeanpartington3)

Dr. Kimberly Biss shared that her clinic saw an increase, with 13 babies lost to miscarriage out of 41 newly registered patients ~ 32%. Her clinic had a 4% miscarriageratevin 2020, prior to CoV injections. In 2021, 7-8%, and in 2022 it was 15%.

“"I've Never Seen This Before": Dr. Kimberly Biss Shares Alarming Fertility Data at the 'Injuries Caused by COVID Vaccines Hearing'

"From what I've seen, my average miscarriage rate in 2020, month-to-month, was 4%. That was normal...My miscarriage rate from year to year went up 100%. In 2021, the average miscarriage rate, month-to-month, was 7-8%. We peaked in November of that year for some reason. That's actually when a non-clinical staff member came up to me and said, 'Dr. Bis, you realize we've had eight miscarriages this month', which in a practice that delivers 20 to 25 patients, that's a huge number. In 2022, the average month-to-month rate was 15%. Now, that was up till November. I will tell you in December. I've never seen this before. We had 41 newly registered patients. 13 of them lost their babies. So that's 25% right there."

@docbiss @RepMTG” Chief Nerd, Nov. 13, 2023, Click for video (x.com/TheChiefNerd)

(x.com/info_maiden)

The Pfizer trial data may have been 80% or 97% based on 28 miscarriages out of 29 pregnancies (first video to click).

“The truth about Pfizer's trials showing an 80% miscarriage rate has been out for a while, yet they pushed forward. Dr. Kim Biss reported a 100% surge in miscarriages post-vaccine, yet the CDC continues to push its safety for pregnant mothers as well as children. Not just a bioweapon, but fertility destruction on a massive scale.” Info Battle Maiden, Sept. 8, 2024, Click for video (x.com/info_maiden)

Addition - the 80% number may be mistaken- see this post by Arkmedic for the science.

The miscarriage of medicine

It’s not easy being a baby. That’s why we need to help them and protect them

Cholinergic blocking effects by a snake venom toxin like sequence within the chimeric spike might be inhibiting nAChRs and mAChRs. Acetylcholine is the main agonist of both receptor types and caffeine protects our supply by inhibiting the enzyme that breaks it down. (recent post)

Coffee in excess is not recommended during pregnancy but losing a pregnancy to a cholinergicblocking toxin is an unusual risk.

Acetylcholine also has immune system functions due to acetylcholine receptors on immune cells - so cholinergic blocking toxins are also reducing immune function.

“Acetylcholine (ACh) is the classical neurotransmitter in the cholinergic nervous system. However, ACh is now known to regulate various immune cell functions. In fact, T cells, B cells, and macrophages all express components of the cholinergic system, including ACh, muscarinic, and nicotinic ACh receptors (mAChRs and nAChRs), choline acetyltransferase, acetylcholinesterase, and choline transporters.” (Mashimo, et al., 2021)

MAChR Dysfunction and Miscarriage (Brave AI summary)

mAChR (Muscarinic Acetylcholine Receptor) dysfunction has been implicated in the pathophysiology of prenatal miscarriage. Here are key findings:

• Cholinergic imbalance: mAChR plays a crucial role in regulating uterine contractility and cervical function during pregnancy. Dysregulation of the cholinergic system, including mAChR dysfunction, may contribute to aberrant uterine contractions and cervical remodeling, leading to miscarriage.

• Abnormal embryo implantation: mAChR signaling is essential for proper embryo implantation and placental development. Dysfunction may disrupt these processes, resulting in failed implantation or early pregnancy loss.

• Inflammation and oxidative stress: mAChR dysfunction may also contribute to an inflammatory and oxidative stress environment in the uterus, which can damage the embryo and lead to miscarriage.

• Variability in symptoms: As mentioned in the search results, miscarriage symptoms can vary widely, and mAChR dysfunction may contribute to this heterogeneity by affecting uterine contractility and cervical function differently in individual cases.

Takeaways:

• mAChR dysfunction is a potential contributor to prenatal miscarriage, particularly in the first trimester.

• Abnormalities in cholinergic signaling, embryo implantation, and uterine environment may all play a role in miscarriage.

• Further research is needed to fully understand the mechanisms underlying mAChR dysfunction in miscarriage and to identify potential therapeutic targets.

Follow up

• What are the specific molecular mechanisms underlying mAChR dysfunction in miscarriage, and how do they impact embryonic development?

• How does mAChR dysfunction interact with other factors, such as hormonal imbalances or genetic mutations, to contribute to miscarriage risk?

• Can mAChR antagonists or agonists be used as potential therapeutic targets to prevent or treat miscarriage, and what are the potential risks and benefits?

1. marchofdimes.org, Miscarriage | March of Dimes

2. acog.org, Early Pregnancy Loss | ACOG

3. my.clevelandclinic.org, Miscarriage: Causes, Sym

It changed the story when I added ‘PubMed’

(search.brave.com/search?q=mAChR+dysfunction+in+prenatal+miscarriage+Pubmed)

a follow up question from that summary:

mAChR Subtypes in Fetal Development (Brave AI summary)

The muscarinic acetylcholine receptor (mAChR) subtypes M1-M5 play crucial roles in regulating fetal development and pregnancy outcomes. Here’s a breakdown of their contributions:

• M1 and M3 subtypes: These receptors are involved in the regulation of placental development and function. Activation of M1 and M3 receptors can stimulate the production of trophoblast-derived factors, essential for implantation and placental growth. Abnormalities in M1 and M3 receptor signaling may contribute to placental dysfunction and pregnancy complications.

• M2 and M4 subtypes: These receptors are primarily expressed in the fetal brain and are involved in the regulation of neuronal migration, differentiation, and survival. Alterations in M2 and M4 receptor signaling may impact fetal brain development and potentially influence neurodevelopmental outcomes.

• M5 subtype: M5 receptors are found in dopamine neurons and play a role in regulating dopamine release. During fetal development, M5 receptors may modulate the activity of dopamine neurons, influencing motor and cognitive development.

Pregnancy Outcomes

Abnormalities in mAChR subtype signaling may contribute to various pregnancy complications, including:

• Preterm labor: Dysregulation of M1 and M3 receptor signaling may lead to altered placental function and premature activation of labor.

• Fetal growth restriction: Impaired M2 and M4 receptor signaling in the fetal brain may impact fetal growth and development.

• Neurodevelopmental disorders: Alterations in M2, M4, and M5 receptor signaling may contribute to the development of neurodevelopmental disorders, such as autism spectrum disorder or attention deficit hyperactivity disorder.

In summary, mAChR subtypes M1-M5 play distinct roles in regulating fetal development and pregnancy outcomes. Abnormalities in their signaling may contribute to various pregnancy complications, highlighting the importance of understanding their functions in this context.

Follow up

• What specific molecular mechanisms underlie the interactions between mAChR subtypes and placental development?

• Can mAChR subtypes serve as biomarkers for predicting fetal growth restriction or neurodevelopmental disorders in pregnancy?

• What is the impact of maternal mAChR subtype expression on fetal brain development and subsequent offspring cognitive and motor function?

1. sciencedirect.com, Muscarinic Acetylcholine Receptor M5 - an overview | ScienceDirect Topics

2. ncbi.nlm.nih.gov, M5 Receptor Activation Produces Opposing Physiological Outcomes in Dopamine Neurons Depending on the Receptor's Location - PMC

3. pubmed.ncbi.nlm.nih.gov, Muscarinic acetylcholine

Disclaimer: This information is being provided for educational purposes within the guidelines of Fair Use and is not intended to provide individual health care guidance.

Reference List

(Mashimo, et al., 2021) Mashimo M, Moriwaki Y, Misawa H, Kawashima K, Fujii T. Regulation of Immune Functions by Non-Neuronal Acetylcholine (ACh) via Muscarinic and Nicotinic ACh Receptors. International Journal of Molecular Sciences. 2021; 22(13):6818. https://doi.org/10.3390/ijms22136818 https://www.mdpi.com/1422-0067/22/13/6818