"St. John’s Wort is a herbal medicinal which modulates serotonin metabolism - how I don’t know."
"St. John’s Wort can inhibit reuptake of serotonin"
Since the ENS produces most of your serotonin, SJW effect on it's metabolism is at the neuron.
Hyperforin (in St. John's Wort) apparently inhibits serotonin uptake by elevating intracellular concentrations of sodium (Na) and calcium (Ca).
Activation of TRPC6 by hyperforin leads to an increase in sodium uptake by neurons, resulting in a decrease of the sodium gradient between the neuron and the synaptic cleft. The loss of the gradient decreases reuptake of the monoamine neurotransmitters. Hyperforin also increases the number of 5-HT receptors.
Blocking the reuptake of serotonin (5-HT) from the synaptic cleft alleviates symptoms of depression by allowing the serotonin to bind to 5-HT receptors and elicit a greater response.
Ahhhhh as I was reading the post I was thinking about how bioplasma cells salts solved my (POTS) insomnia! I didn’t understand how but your comment sheds some light. Thank you!
You didn't miss it, but may have missed my saying I didn't find the right link regarding a drop in serotonin being associated with 3 am wake-up. I found a more general 🧬 nk about neurotransmitters role in fleep. Serotonin works in balance with others and is not the elevated one at night. So, it probably isn't thought of as a sleep chemical. More is present during wakefulness. BUT it is ratios that seem to affect sleep and St John's Wort affects serotonin and norepinephrine levels, so it may be helping the ratio issue.
I wanted to move on with my day. If I were to redig for it I would look from the St. John's Wort herbalist info direction. Maybe I had seen something in that years ago.
Or I would look at the body click of Traditional Chinese Medicine - hormone flux occurs in a consistent way around the clock, so the 3-4am zone must be hitting onf if those zones.
JD - Excellent missive.
"St. John’s Wort is a herbal medicinal which modulates serotonin metabolism - how I don’t know."
"St. John’s Wort can inhibit reuptake of serotonin"
Since the ENS produces most of your serotonin, SJW effect on it's metabolism is at the neuron.
Hyperforin (in St. John's Wort) apparently inhibits serotonin uptake by elevating intracellular concentrations of sodium (Na) and calcium (Ca).
Activation of TRPC6 by hyperforin leads to an increase in sodium uptake by neurons, resulting in a decrease of the sodium gradient between the neuron and the synaptic cleft. The loss of the gradient decreases reuptake of the monoamine neurotransmitters. Hyperforin also increases the number of 5-HT receptors.
Blocking the reuptake of serotonin (5-HT) from the synaptic cleft alleviates symptoms of depression by allowing the serotonin to bind to 5-HT receptors and elicit a greater response.
https://www.ncbi.nlm.nih.gov/books/NBK92750/
Woot woot, you found the answer and TRP channel.Thanks for sharing NN.
Ahhhhh as I was reading the post I was thinking about how bioplasma cells salts solved my (POTS) insomnia! I didn’t understand how but your comment sheds some light. Thank you!
Thank you Jennifer...
- just when one was questioning continued subscription to substack...
Your research helps solve a puzzle once again.
Many thanks.
Hmmm... I didn't find the part discussing why it would stop the middle of the night wakefulness... is it in one of the links?
You didn't miss it, but may have missed my saying I didn't find the right link regarding a drop in serotonin being associated with 3 am wake-up. I found a more general 🧬 nk about neurotransmitters role in fleep. Serotonin works in balance with others and is not the elevated one at night. So, it probably isn't thought of as a sleep chemical. More is present during wakefulness. BUT it is ratios that seem to affect sleep and St John's Wort affects serotonin and norepinephrine levels, so it may be helping the ratio issue.
I wanted to move on with my day. If I were to redig for it I would look from the St. John's Wort herbalist info direction. Maybe I had seen something in that years ago.
Or I would look at the body click of Traditional Chinese Medicine - hormone flux occurs in a consistent way around the clock, so the 3-4am zone must be hitting onf if those zones.