Amyloidosis was reduced by C60, Fullerene - an Nrf2 promoter in antioxidant form.

C60 is 60 carbon atoms in a sphere shape. It can be an antioxidant or a pro-oxidant. Dilute in olive oil not water or the pro-oxidant form is created.

Research in 2010, (1), found that Carbon 60 in the Fullerene form acts as an Nrf2 promoter, (1, 2), and treatment with it, (in olive oil type dilution), helped reduce misfolded protein buildup in an Alzheimer’s model. (1) This information supports my theory that the spike promotion of NF-kB is also causing dysfunction due to the resulting inhibition of Nrf2 and that Nrf2 promoters then can be a treatment to help stop the misfolded protein accumulation.

*C60 references and CoV treatment suggestion via @observadora007.

Fig. 1.11. Nanoallotropes of carbon. (6, viewable at 5)

New hopes in the fight against the development of Alzheimer's, (3), is a helpful article in Spanish, this is a Google translation of part of the article. It includes details about what the substances are and how they help the body. Many, at a glance, are Nrf2 promoters or act as mitochondrial support. Some of the supplements reviewed are available to order in the link, (3):

“Alongside the classic supplements (acetyl-L-carnitine, alpha-lipoic acid, omega 3, green tea, turmeric, Ginkgo biloba), innovative molecules appear to preserve cognitive faculties. By acting on multiple parameters: inhibition of acetylcholinesterase, elimination of beta-amyloid plaques and fight against oxidative aggression and against chronic inflammation, these appear as very promising substances for all Alzheimer's patients.

To provide significant help to people suffering from mild or moderate forms, it is necessary to have substances that have already been tested in multiple scientific studies. Among these, acetyl-L-carnitine, alpha-lipoic acid (ALA), long-chain omega-3 fatty acids, green tea, turmeric and Ginkgo biloba stand out. These substances protect against oxidative aggression, delay cognitive deterioration, favor the synthesis of acetylcholine or prevent its degradation, slow down the progression of dementia, improve cognitive performance, reduce the deposits of beta-amyloid plaques or favor their elimination, or act…against oxidation and inflammation. (3)

New molecules tested

Galantamine to increase acetylcholine levels
Two major clinical studies in people with Alzheimer's have achieved rapid and dramatic improvements in memory, learning, as well as cognitive and behavioral gains. Indeed, galantamine, perfectly tolerated, slows down the deterioration of cognitive and functional abilities by:

• Inhibit acetylcholinesterase and therefore increase acetylcholine levels.

• Stimulate the action of acetylcholine in its brain receptors.

• Allow a better cerebral blood supply, thus improving cognitive performance.

• Stimulate, like tobacco, certain specific receptors in the brain, the alpha-7 nicotinic receptors, thus improving learning, memory, attention and concentration.

For more than twenty years, Galantamine has aroused great interest throughout the world and is indicated in the United States for Alzheimer's patients, where it is also authorized for this indication by the Food and Drug Administration (FDA). (3)

Tangent: “Cytisine and cytisine derivatives” may also be effective as a non-nicotine nAChR receptor agonist. (4) The chimeric spike can act as a paralytic similar to Conotoxin or snake venom toxin, making nicotine protective of the nAChR function which is critical for sensory signaling to the brain and for fetal implantation and development.

• Homotaurine

• Nicotinamide riboside (NR)

• Sulbutiamine

• Andrographis

• Magnesium Threonate

• Huperzine A

• Uridine-5'-monophosphate

Other promising substances

• Fullerene C60

• Ursolic Acid

• The Noopept

• L-alpha-glyceryl-phosphoryl-choline

• Pterostilbene , chemically close to resveratrol.

• Pyrroloquinoline quinone (PQQ).” (3)

Health is difficult in modern life, and turning back to nature can help us restore our quality of life - whether walking in the forest, or taking evergreen based phytonutrients - nature has our back.

Disclaimer: This information is provided for educational purposes within the guidelines of fair use. While I am a Registered Dietitian this information is not intended to provide individual health guidance. Please see a health professional for individual health care purposes.

Reference List

1. Podol'skiĭ IIa, Poddubnaia ZA, Godukhin OV. [Fullerenes C60, antiamyloid action, the brain and cognitive processes]. Biofizika. 2010 Jan-Feb;55(1):88-94. Russian. PMID: 20184146. https://pubmed.ncbi.nlm.nih.gov/20184146/

2. Gonchar OO, Maznychenko AV, Klyuchko OM, Mankovska IM, Butowska K, Borowik A, Piosik J, Sokolowska I. C60 Fullerene Reduces 3-Nitropropionic Acid-Induced Oxidative Stress Disorders and Mitochondrial Dysfunction in Rats by Modulation of p53, Bcl-2 and Nrf2 Targeted Proteins. Int J Mol Sci. 2021 May 21;22(11):5444. doi: 10.3390/ijms22115444. PMID: 34064070; PMCID: PMC8196695. https://pubmed.ncbi.nlm.nih.gov/34064070/

3. New hopes in the fight against the development of Alzheimer's. June 8, 2017, nutranews.org, https://www.nutranews.org/es--alzheimer-enfermedad--nuevas-esperanzas-lucha-contra-el-desarrollo-alzheimer--1325

4. Gotti C, Clementi F. Cytisine and cytisine derivatives. More than smoking cessation aids. Pharmacol Res. 2021 Aug;170:105700. doi: 10.1016/j.phrs.2021.105700. Epub 2021 Jun 2. PMID: 34087351. https://pubmed.ncbi.nlm.nih.gov/34087351/ via https://twitter.com/4141245879freun/status/1539735953861971968?s=20

5. C60 - Fullerene, ScienceDirect.com, https://www.sciencedirect.com/topics/chemistry/c60-fullerene

6. Nasrollahzadeh M, Sajadi SM, Sajjadi M, Issaabadi Z, Chapter 1 - An Introduction to Nanotechnology, Editor(s): Mahmoud Nasrollahzadeh, S. Mohammad Sajadi, Mohaddeseh Sajjadi, Zahra Issaabadi, Monireh Atarod,

   Interface Science and Technology, Elsevier, Vol 28, 2019, pp 1-27, ISSN 1573-4285, ISBN 9780128135860, https://doi.org/10.1016/B978-0-12-813586-0.00001-8. https://www.sciencedirect.com/science/article/abs/pii/B9780128135860000018

• McGeer, P.L., McGeer, E.G. The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy. Acta Neuropathol 126, 479–497 (2013). https://doi.org/10.1007/s00401-013-1177-7 https://link.springer.com/article/10.1007/s00401-013-1177-7

• Mörz, M. A Case Report: Multifocal Necrotizing Encephalitis and Myocarditis after BNT162b2 mRNA Vaccination against Covid-19. Preprints 2022, 2022060308 (doi: 10.20944/preprints202206.0308.v1). https://www.preprints.org/manuscript/202206.0308/v1

• via Walter Chestnut, https://wmcresearch.substack.com/p/the-spike-protein-the-amyloid-cascade